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unc-25 Protein UNC-25 [ Caenorhabditis elegans ]

Gene ID: 176713, updated on 7-Sep-2014
Gene symbol
unc-25
Gene description
Protein UNC-25
Locus tag
CELE_Y37D8A.23
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (old-lineage: Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
See unc-25 in MapViewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.9 (12942560..12949613)

Chromosome III - NC_003281.9Genomic Context describing neighboring genes Neighboring gene Protein Y37D8A.21 Neighboring gene Protein Y37D8A.19 Neighboring gene Protein EPG-3 Neighboring gene Protein Y39E4A.1 Neighboring gene Protein TTM-1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glutamate decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
gamma-aminobutyric acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
inhibitory synapse IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Names
Protein UNC-25
NP_001022831.1
  • C. elegans UNC-25 protein; contains similarity to Pfam domain PF00282 Pyridoxal-dependent decarboxylase conserved domain contains similarity to Interpro domain IPR002129 (Pyridoxal phosphate-dependent decarboxylase);~Confirmed by transcript evidence
NP_001022832.1
  • C. elegans UNC-25 protein; contains similarity to Pfam domain PF00282 Pyridoxal-dependent decarboxylase conserved domain contains similarity to Interpro domain IPR002129 (Pyridoxal phosphate-dependent decarboxylase);~Confirmed by transcript evidence
NP_499689.1
  • Confirmed by transcript evidence;~Pyridoxal-dependent decarboxylase conserved domain

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.9 

    Range
    12942560..12949613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067288.4NP_499689.1  Protein UNC-25, isoform a [Caenorhabditis elegans]

    See proteins identical to NP_499689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDB7
    Conserved Domains (1) summary
    cd06450
    Location:102503
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  2. NM_001027660.2NP_001022831.1  Protein UNC-25, isoform b [Caenorhabditis elegans]

    See proteins identical to NP_001022831.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4E0
    Conserved Domains (1) summary
    cd06450
    Location:102429
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
  3. NM_001027661.2NP_001022832.1  Protein UNC-25, isoform c [Caenorhabditis elegans]

    See proteins identical to NP_001022832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4D9
    Conserved Domains (1) summary
    cd06450
    Location:27428
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...