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DNM1 dynamin 1 [ Homo sapiens (human) ]

Gene ID: 1759, updated on 8-May-2016
Official Symbol
DNM1provided by HGNC
Official Full Name
dynamin 1provided by HGNC
Primary source
HGNC:HGNC:2972
See related
Ensembl:ENSG00000106976 HPRD:03851; MIM:602377; Vega:OTTHUMG00000020733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNM; EIEE31
Summary
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q34
Exon count:
26
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (128203355..128255249)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130965634..131017528)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 16 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene uncharacterized LOC105376285 Neighboring gene microRNA 199b Neighboring gene microRNA 3154 Neighboring gene golgin A2 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene uncharacterized LOC105376286 Neighboring gene TruB pseudouridine synthase family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Epileptic encephalopathy, early infantile, 31
MedGen: CN230178 OMIM: 616346 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed

Go to the HIV-1, Human Interaction Database

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR3-mediated signaling events, organism-specific biosystem
    CXCR3-mediated signaling events
  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHB forward signaling, organism-specific biosystem
    EPHB forward signaling
  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
    Ephrin B reverse signaling, organism-specific biosystem
    Ephrin B reverse signaling
  • Formation of annular gap junctions, organism-specific biosystem (from REACTOME)
    Formation of annular gap junctions, organism-specific biosystemGap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate w...
  • Gap junction degradation, organism-specific biosystem (from REACTOME)
    Gap junction degradation, organism-specific biosystemThe half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the...
  • Gap junction trafficking, organism-specific biosystem (from REACTOME)
    Gap junction trafficking, organism-specific biosystemGap junctions are intercellular communication channels formed from Cx (connexin) protein subunits (see Segretain and Falk 2004 and Evans et al. 2006 for comprehensive reviews). Connexins are transpor...
  • Gap junction trafficking and regulation, organism-specific biosystem (from REACTOME)
    Gap junction trafficking and regulation, organism-specific biosystemGap junctions are clusters of intercellular channels connecting adjacent cells and permitting the direct exchange of ions and small molecules between cells. These channels are composed of two hemicha...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
    Internalization of ErbB1, organism-specific biosystem
    Internalization of ErbB1
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Notch signaling pathway, organism-specific biosystem
    Notch signaling pathway
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
    Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
  • Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
    Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Synaptic Vesicle Pathway, organism-specific biosystem (from WikiPathways)
    Synaptic Vesicle Pathway, organism-specific biosystemPathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytos...
  • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
    Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Synaptic vesicle cycle, conserved biosystem (from KEGG)
    Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Thromboxane A2 receptor signaling, organism-specific biosystem
    Thromboxane A2 receptor signaling
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D2 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nitric-oxide synthase binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
clathrin-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis TAS
Traceable Author Statement
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of synaptic vesicle recycling IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane coat IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
varicosity IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dynamin-1
NP_001005336.1
NP_001275666.1
NP_001275667.1
NP_001275668.1
NP_004399.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029726.1 RefSeqGene

    Range
    4972..56865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005336.2NP_001005336.1  dynamin-1 isoform 2

    See identical proteins and their annotated locations for NP_001005336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting isoform (2), also known as internal form 2 and the short C-terminal form, is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI660320, BC050279, BC063850, DA221568
    Consensus CDS
    CCDS43882.1
    UniProtKB/Swiss-Prot
    Q05193
    Related
    ENSP00000345680, OTTHUMP00000215499, ENST00000341179, OTTHUMT00000355653
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  2. NM_001288737.1NP_001275666.1  dynamin-1 isoform 3

    See identical proteins and their annotated locations for NP_001275666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, and includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AI660320, AK296326, BC050279, BC063850, DA221568, DA510154, L07810
    Consensus CDS
    CCDS75911.1
    UniProtKB/Swiss-Prot
    Q05193
    UniProtKB/TrEMBL
    B4DK06
    Related
    ENSP00000377219, OTTHUMP00000022237, ENST00000393594, OTTHUMT00000054368
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  3. NM_001288738.1NP_001275667.1  dynamin-1 isoform 3

    See identical proteins and their annotated locations for NP_001275667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, and includes an alternate exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AI660320, AK316235, AL590708, BC050279, BG396820, DA221568, DA510154
    Consensus CDS
    CCDS75911.1
    UniProtKB/Swiss-Prot
    Q05193
    UniProtKB/TrEMBL
    B7ZAC0
    Related
    ENSP00000419225, OTTHUMP00000215498, ENST00000475805, OTTHUMT00000355651
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  4. NM_001288739.1NP_001275668.1  dynamin-1 isoform 4

    See identical proteins and their annotated locations for NP_001275668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal alternate in-frame exon, and contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is the same length as isoform 1 but differs in an internal region compared to isoform 1.
    Source sequence(s)
    AI660320, AK225179, BC050279, BC063850, DA221568, DA510154
    Consensus CDS
    CCDS75912.1
    UniProtKB/Swiss-Prot
    Q05193
    Related
    ENSP00000420045, OTTHUMP00000215500, ENST00000486160, OTTHUMT00000355654
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  5. NM_004408.3NP_004399.2  dynamin-1 isoform 1

    See identical proteins and their annotated locations for NP_004399.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 has been referred to as internal form 1 and the long C-terminal form.
    Source sequence(s)
    AI660320, BC050279, BC063850, DA221568
    Consensus CDS
    CCDS6895.1
    UniProtKB/Swiss-Prot
    Q05193
    Related
    ENSP00000362014, OTTHUMP00000022236, ENST00000372923, OTTHUMT00000054367
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    128203355..128255249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251769.1XP_005251826.1  

    See identical proteins and their annotated locations for XP_005251826.1

    UniProtKB/Swiss-Prot
    Q05193
    Related
    ENSP00000487310, OTTHUMP00000279365, ENST00000627543, OTTHUMT00000484409
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  2. XM_005251763.1XP_005251820.1  

    See identical proteins and their annotated locations for XP_005251820.1

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  3. XM_011518336.1XP_011516638.1  

    See identical proteins and their annotated locations for XP_011516638.1

    UniProtKB/TrEMBL
    A0A0D9SFE4
    Related
    ENSP00000486525, OTTHUMP00000279313, ENST00000628346, OTTHUMT00000484332
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78600
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  4. XM_011518337.1XP_011516639.1  

    See identical proteins and their annotated locations for XP_011516639.1

    UniProtKB/Swiss-Prot
    Q05193
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  5. XM_005251768.1XP_005251825.1  

    See identical proteins and their annotated locations for XP_005251825.1

    UniProtKB/Swiss-Prot
    Q05193
    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  6. XM_006716992.1XP_006717055.1  

    See identical proteins and their annotated locations for XP_006717055.1

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  7. XM_005251764.1XP_005251821.1  

    See identical proteins and their annotated locations for XP_005251821.1

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656745
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  8. XM_011518334.1XP_011516636.1  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  9. XM_011518335.1XP_011516637.1  

    Conserved Domains (5) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78600
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652741
    GED; Dynamin GTPase effector domain
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
  10. XM_011518338.1XP_011516640.1  

    Conserved Domains (3) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78500
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region
  11. XM_006716993.1XP_006717056.1  

    Conserved Domains (3) summary
    cd08771
    Location:29294
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:78496
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:216487
    Dynamin_M; Dynamin central region

RNA

  1. XR_242573.2 RNA Sequence

  2. XR_242572.1 RNA Sequence

  3. XR_929730.1 RNA Sequence

  4. XR_929729.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    131116658..131168550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)