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    atp-2 ATP synthase subunit [ Caenorhabditis elegans ]

    Gene ID: 175716, updated on 6-May-2012
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    Summary

    Gene symbol
    atp-2
    Gene description
    ATP synthase subunit
    Primary source
    WormBase:WBGene00000229
    Locus tag
    C34E10.6
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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    Genomic context

    Location :
    chromosome: III
    Sequence :
    Chromosome: III; NC_003281.8 (5228374..5230503)
    See atp-2 in MapViewer

    Chromosome III - NC_003281.8Genomic Context describing neighboring genes Neighboring gene anNEXin family Neighboring gene hypothetical protein Neighboring gene PRotein arginine MethylTransferase Neighboring gene hypothetical protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480.
    2. Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic. Balklava Z, et al. Nat Cell Biol, 2007 Sep. PMID 17704769.
    3. Lifespan regulation by evolutionarily conserved genes essential for viability. Curran SP, et al. PLoS Genet, 2007 Apr 6. PMID 17411345.
    4. ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Hu J, et al. Mol Biol Cell, 2005 Feb. PMID 15563610.
    5. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. atp-2 is involved in the production or the regulation of a global, developmental signal required for the L3-to-L4 transition.
      Title: Mitochondrial ATP synthase controls larval development cell nonautonomously in Caenorhabditis elegans.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:40947 BioGRID:40107 F13D12.6    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:43279 F28D1.2    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:37602 aap-1    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:39791 aqp-2    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:45907 bar-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40947 BioGRID:41273 clk-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40947 BioGRID:40655 daf-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40947 BioGRID:41009 daf-4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:40947 BioGRID:41058 dnc-2    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:532260 ech-2    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:532329 kel-8    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:40862 rps-0    BioGRID  PubMed Two-hybrid 
    BioGRID:40947 BioGRID:45273 ttx-1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    • Homologs of the atp-2 gene: The atp-2 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.

    Pathways from BioSystems

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    hydrogen ion transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    hydrogen-exporting ATPase activity, phosphorylative mechanism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    ATP synthesis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    proton transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    reproduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to hermaphrodite contact IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    proton-transporting two-sector ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    proton-transporting two-sector ATPase complex, catalytic domain IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
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    General protein information

    Names
    ATP synthase subunit family member (atp-2)
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.8

      Range
      5228374..5230503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065710.4 → NP_498111.2  ATP synthase subunit family member (atp-2) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46561
      Conserved Domains (4) summary
      cd01133
      Location:140 – 419
      Blast Score: 1255
      F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...
      pfam00306
      Location:427 – 531
      Blast Score: 305
      ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
      PRK09280
      Location:71 – 533
      Blast Score: 2377
      PRK09280; F0F1 ATP synthase subunit beta; Validated
      cl15275
      Location:72 – 138
      Blast Score: 175
      ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic U10402.2 AAA19068.2
    genomic BX284603.2 AAA19068.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46561.2 GenPept
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    Additional Links

    Gene LinkOut

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