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    DMD dystrophin [ Homo sapiens ]

    Gene ID: 1756, updated on 21-May-2012

    Summary

    Official Symbol
    DMDprovided by HGNC
    Official Full Name
    dystrophinprovided by HGNC
    Primary source
    HGNC:2928
    Locus tag
    GS1-19O24.1
    See related
    Ensembl:ENSG00000198947; HPRD:02303; MIM:300377; Vega:OTTHUMG00000021336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMD; CMD3B; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
    Summary
    The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    Location :
    Xp21.2
    Sequence :
    Chromosome: X; NC_000023.10 (31137345..33357726, complement)

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 3 Neighboring gene ferritin, heavy polypeptide-like 17 Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 8 Neighboring gene microRNA 3915 Neighboring gene microRNA 548f-5 Neighboring gene tubulin folding cofactor A pseudogene 1 Neighboring gene lysosomal-associated membrane protein 1 pseudogene Neighboring gene family with sequence similarity 47, member A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P11532 P68133 ACTA1    HPRD  PubMed  
    P11532 P68032 ACTC1    HPRD  PubMed  
    P11532 Q9ULU8 CADPS    HPRD  PubMed  
    P11532 Q86UW7 CADPS2    HPRD  PubMed  
    P11532 Q14118 DAG1    HPRD  PubMed  
    P11532 Q13574 DGKZ    HPRD  PubMed  
    P11532 P11532 DMD    HPRD  PubMed  
    P11532 Q9Y4J8 DTNA    HPRD  PubMed  
    P11532 O60941 DTNB    HPRD  PubMed  
    P11532 P48023 FASLG    HPRD  PubMed  
    P11532 Q14500 KCNJ12    HPRD  PubMed  
    P11532 P08727 KRT19    HPRD  PubMed  
    P11532 P05787 KRT8    HPRD  PubMed  
    P11532 Q15124 PGM5    HPRD  PubMed  
    P11532 Q96LD1 SGCZ    HPRD  PubMed  
    P11532 Q13424 SNTA1    HPRD  PubMed  
    P11532 Q13884 SNTB1    HPRD  PubMed  
    P11532 Q13425 SNTB2    HPRD  PubMed  
    P11532 Q9NSN8 SNTG1    HPRD  PubMed  
    P11532 Q9NY99 SNTG2    HPRD  PubMed  
    P11532 P46939 UTRN    HPRD  PubMed  
    BioGRID:108096 BioGRID:106573 ACTA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108096 BioGRID:107975 DAG1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure 
    BioGRID:108096 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:108096 BioGRID:108170 DTNA    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108096 BioGRID:108171 DTNB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108096 BioGRID:246668 Itgb1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108096 BioGRID:109970 KCNJ12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108096 BioGRID:109963 KCNJ4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108096 BioGRID:110381 MAP3K5    BioGRID  PubMed Two-hybrid 
    BioGRID:108096 BioGRID:247643 Ptk2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108096 BioGRID:112523 SNTA1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:108096 BioGRID:112524 SNTB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108096 BioGRID:112528 SNTB2    BioGRID  PubMed Protein-peptide 
    BioGRID:108096 BioGRID:263295 Snta1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108096 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108096 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108096 BioGRID:117577 TRAF3IP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108096 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Pathways from BioSystems

    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystem
      Striated Muscle Contraction
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    beta-dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    dystroglycan binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural constituent of muscle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    muscle cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    muscle filament sliding TAS
    Traceable Author Statement
    more info
     
    muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    peptide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-substrate junction IEA
    Inferred from Electronic Annotation
    more info
     
    costamere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dystrophin-associated glycoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dystrophin-associated glycoprotein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    dystrophin-associated glycoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    microsome IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection terminus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dystrophin
    Names
    dystrophin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012232.1 RefSeqGene

      Range
      5001..2225382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000109.3NP_000100.2  dystrophin Dp427c isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp427c is expressed predominantly in neurons of the cortex and the CA regions of the hippocampus. It uses a unique promoter/exon 1 located about 130 kb upstream of the Dp427m transcript promoter. The transcript includes the common exon 2 of transcript Dp427m and has a similar length of 14 kb. The Dp427c isoform contains a unique N-terminal MED sequence, instead of the MLWWEEVEDCY sequence of isoform Dp427m. The remainder of isoform Dp427c is identical to isoform Dp427m.
      Source sequence(s)
      AL050305, AL109609, BC028720, BC036103, M18533
      UniProtKB/Swiss-Prot
      P11532
      UniProtKB/TrEMBL
      Q4G0X0
      Conserved Domains (8) summary
      cd00014
      Location:127232
      Blast Score: 209
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:24642680
      Blast Score: 190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:30513080
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:33033351
      Blast Score: 271
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:16961971
      Blast Score: 110
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:30793199
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:32033294
      Blast Score: 416
      efhand_2; EF-hand
      cl02488
      Location:16711768
      Blast Score: 123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. NM_004006.2NP_003997.1  dystrophin Dp427m isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp427m encodes the main dystrophin protein found in muscle. As a result of alternative promoter use, exon 1 encodes a unique N-terminal MLWWEEVEDCY aa sequence.
      Source sequence(s)
      AL031643, AL109609, BC028720, M18533
      Consensus CDS
      CCDS14233.1
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000354923, OTTHUMP00000023117, ENST00000357033, OTTHUMT00000056182
      Conserved Domains (8) summary
      cd00014
      Location:135240
      Blast Score: 209
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:24722688
      Blast Score: 190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:30593088
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:33113359
      Blast Score: 271
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:17041979
      Blast Score: 111
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:30873207
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:32113302
      Blast Score: 416
      efhand_2; EF-hand
      cl02488
      Location:16791776
      Blast Score: 123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. NM_004007.2NP_003998.1  dystrophin Dp427l isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp427l originates at a unique promoter/exon 1 with splicing to exon 3 of the full length dystrophin (Dp427m) transcript. Consequently, amino acids 1-31 are replaced by a single methionine.
      Source sequence(s)
      AC004468, AC006061, AC078958, AC079143, AC079175, AC079177, AC079864, AC090632, AC093167, AC093193, AC096506, AL031542, AL096699, AL109609, AL139278, AL451144, D32048, M18533
      Conserved Domains (8) summary
      cd00014
      Location:12117
      Blast Score: 210
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:23492565
      Blast Score: 188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:29362965
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31883236
      Blast Score: 271
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:15811856
      Blast Score: 109
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:29643084
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:30883179
      Blast Score: 416
      efhand_2; EF-hand
      cl02488
      Location:15561653
      Blast Score: 122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. NM_004009.3NP_004000.1  dystrophin Dp427p1 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp427p1 initiates from a unique promoter/exon 1 located in what corresponds to the first intron of transcript Dp427m. The transcript adds the common exon 2 of Dp427m and has a similar length (14 kb). The Dp427p1 isoform replaces the MLWWEEVEDCY-start of Dp427m with a unique N-terminal MSEVSSD aa sequence.
      Source sequence(s)
      AL049643, AL109609, BC028720, M18533, S64152
      Consensus CDS
      CCDS55395.1
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000367948, OTTHUMP00000023121, ENST00000378677, OTTHUMT00000056187
      Conserved Domains (8) summary
      cd00014
      Location:131236
      Blast Score: 209
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:24682684
      Blast Score: 190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:30553084
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:33073355
      Blast Score: 272
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:17001975
      Blast Score: 111
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:30833203
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:32073298
      Blast Score: 416
      efhand_2; EF-hand
      cl02488
      Location:16751772
      Blast Score: 123
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    5. NM_004010.3NP_004001.1  dystrophin Dp427p2 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp427p2 has an additional 82 nt directly after exon 1 which introduces a translational stop codon 24 bp downstream of the same ATG codon included in the Dp427p1 transcript. This transcript has unknown coding capacity.
      Source sequence(s)
      AL049643, AL109609, BC028720, M18533, S64152
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000444221, ENST00000535280
      Conserved Domains (8) summary
      cd00014
      Location:12117
      Blast Score: 210
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:23492565
      Blast Score: 188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:29362965
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31883236
      Blast Score: 271
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:15811856
      Blast Score: 109
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:29643084
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:30883179
      Blast Score: 416
      efhand_2; EF-hand
      cl02488
      Location:15561653
      Blast Score: 122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. NM_004011.3NP_004002.2  dystrophin Dp260-1 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp260-1 uses exons 30-79, and originates from a promoter/exon 1 sequence located in intron 29 of the dystrophin gene. As a result, Dp260-1 contains a 95 bp exon 1 encoding a unique N-terminal 16 aa MTEIILLIFFPAYFLN-sequence that replaces amino acids 1-1357 of the full-length dystrophin product (Dp427m isoform).
      Source sequence(s)
      AL109609, BC028720, M18533
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000367953, ENST00000378682
      Conserved Domains (4) summary
      cd00176
      Location:11311347
      Blast Score: 188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:17181747
      Blast Score: 118
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:19702018
      Blast Score: 272
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:363638
      Blast Score: 108
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
    7. NM_004012.3NP_004003.1  dystrophin Dp260-2 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp260-2 uses exons 30-79, starting from a promoter/exon 1 sequence located in intron 29 of the dystrophin gene that is alternatively spliced and lacks N-terminal amino acids 1-1357 of the full length dystrophin (Dp427m isoform). The Dp260-2 transcript encodes a unique N-terminal MSARKLRNLSYKK sequence.
      Source sequence(s)
      AL109609, BC028720, M18533
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000367955, ENST00000378684
      Conserved Domains (7) summary
      cd00176
      Location:11281344
      Blast Score: 186
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:17151744
      Blast Score: 118
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:19672015
      Blast Score: 272
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      COG1340
      Location:360635
      Blast Score: 107
      COG1340; Uncharacterized archaeal coiled-coil protein [Function unknown]
      pfam09068
      Location:17431863
      Blast Score: 453
      efhand_1; EF hand
      pfam09069
      Location:18671958
      Blast Score: 417
      efhand_2; EF-hand
      cl02488
      Location:335432
      Blast Score: 122
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. NM_004013.2NP_004004.1  dystrophin Dp140 isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp140 transcripts use exons 45-79, starting at a promoter/exon 1 located in intron 44. Dp140 transcripts have a long (1 kb) 5' UTR since translation is initiated in exon 51 (corresponding to aa 2461 of dystrophin). In addition to the alternative promoter and exon 1, differential splicing of exons 71-74 and 78 produces at least five Dp140 isoforms. Of these, this transcript (Dp140) contains all of the exons.
      Source sequence(s)
      BC028720, DA804849, M18533
      Consensus CDS
      CCDS48091.1
      UniProtKB/TrEMBL
      A1L0U9
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000367979, ENST00000378707
      Conserved Domains (5) summary
      cd00176
      Location:12228
      Blast Score: 207
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:599628
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:851899
      Blast Score: 267
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:627747
      Blast Score: 451
      efhand_1; EF hand
      pfam09069
      Location:751842
      Blast Score: 416
      efhand_2; EF-hand
    9. NM_004014.2NP_004005.1  dystrophin Dp116 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp116 uses exons 56-79, starting from a promoter/exon 1 within intron 55. As a result, the Dp116 isoform contains a unique N-terminal MLHRKTYHVK aa sequence, instead of aa 1-2739 of dystrophin. Differential splicing produces several Dp116-subtypes. The Dp116 isoform is also known as S-dystrophin or apo-dystrophin-2.
      Source sequence(s)
      AC079175, BC028720, M18533
      UniProtKB/Swiss-Prot
      P11532
      Conserved Domains (5) summary
      cd00176
      Location:206316
      Blast Score: 152
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:330359
      Blast Score: 117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:582630
      Blast Score: 258
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:358478
      Blast Score: 453
      efhand_1; EF hand
      pfam09069
      Location:482573
      Blast Score: 417
      efhand_2; EF-hand
    10. NM_004015.2NP_004006.1  dystrophin Dp71 isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp71 transcripts use exons 63-79 with a novel 80- to 100-nt exon containing an ATG start site for a new coding sequence of 17 nt. The short coding sequence is in-frame with the consecutive dystrophin sequence from exon 63. Differential splicing of exons 71 and 78 produces at least four Dp71 isoforms. Of these, this transcript (Dp71) includes both exons 71 and 78.
      Source sequence(s)
      BC028720, BC070078, BC094758
      Consensus CDS
      CCDS14234.1
      UniProtKB/TrEMBL
      E9PDN1
      UniProtKB/TrEMBL
      Q6NSJ9
      Related
      ENSP00000367974, OTTHUMP00000023126, ENST00000378702, OTTHUMT00000056196
      Conserved Domains (4) summary
      cd02334
      Location:243291
      Blast Score: 246
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:19139
      Blast Score: 454
      efhand_1; EF hand
      pfam09069
      Location:143234
      Blast Score: 418
      efhand_2; EF-hand
      cl02600
      Location:488530
      Blast Score: 83
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    11. NM_004016.2NP_004007.1  dystrophin Dp71b isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp71 transcripts use exons 63-79 with a novel 80- to 100-nt exon containing an ATG start site for a new coding sequence of 17 nt. The short coding sequence is in-frame with the consecutive dystrophin sequence from exon 63. Differential splicing of exons 71 and 78 produces at least four Dp71 isoforms. Of these, this transcript (Dp71b) lacks exon 78 and encodes a protein with a different C-terminus than Dp71 and Dp71a isoforms.
      Source sequence(s)
      BC028720, BC094758
      Consensus CDS
      CCDS14231.1
      Related
      ENSP00000367997, OTTHUMP00000023124, ENST00000378723, OTTHUMT00000056194
      Conserved Domains (4) summary
      cd02334
      Location:243291
      Blast Score: 247
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:19139
      Blast Score: 453
      efhand_1; EF hand
      pfam09069
      Location:143234
      Blast Score: 417
      efhand_2; EF-hand
      cl02600
      Location:488530
      Blast Score: 84
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    12. NM_004017.2NP_004008.1  dystrophin Dp71a isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp71 transcripts use exons 63-79 with a novel 80- to 100-nt exon containing an ATG start site for a new coding sequence of 17 nt. The short coding sequence is in-frame with the consecutive dystrophin sequence from exon 63. Differential splicing of exons 71 and 78 produces at least four Dp71 isoforms. Of these, this transcript (Dp71a) lacks exon 71.
      Source sequence(s)
      BC028720, BC070078, M92650
      UniProtKB/Swiss-Prot
      P11532
      UniProtKB/TrEMBL
      Q6NSJ9
      Conserved Domains (4) summary
      cd02334
      Location:243291
      Blast Score: 245
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:19139
      Blast Score: 453
      efhand_1; EF hand
      pfam09069
      Location:143234
      Blast Score: 418
      efhand_2; EF-hand
      cl02600
      Location:475517
      Blast Score: 83
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    13. NM_004018.2NP_004009.1  dystrophin Dp71ab isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp71 transcripts use exons 63-79 with a novel 80- to 100-nt exon containing an ATG start site for a new coding sequence of 17 nt. The short coding sequence is in-frame with the consecutive dystrophin sequence from exon 63. Differential splicing of exons 71 and 78 produces at least four Dp71 isoforms. Of these, this transcript (Dp71ab) lacks both exons 71 and 78 and encodes a protein with a C-terminus like isoform Dp71b.
      Source sequence(s)
      BC028720, DB233002, M92650
      Consensus CDS
      CCDS14232.1
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000354464, OTTHUMP00000023125, ENST00000361471, OTTHUMT00000056195
      Conserved Domains (4) summary
      cd02334
      Location:243291
      Blast Score: 246
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:19139
      Blast Score: 452
      efhand_1; EF hand
      pfam09069
      Location:143234
      Blast Score: 417
      efhand_2; EF-hand
      cl02600
      Location:475517
      Blast Score: 83
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    14. NM_004019.2NP_004010.1  dystrophin Dp40 isoform

      Status: REVIEWED

      Description
      Transcript Variant: transcript Dp40 uses exons 63-70. The 5' UTR and encoded first 7 aa are identical to that in transcript Dp71, but the stop codon lies at the splice junction of the exon/intron 70. The 3' UTR includes nt from intron 70 which includes an alternative polyadenylation site. The Dp40 isoform lacks the normal C-terminal end of full-length dystrophin (aa 3409-3685).
      Source sequence(s)
      AC078958, M18533, S42206
      UniProtKB/Swiss-Prot
      P11532
      UniProtKB/TrEMBL
      Q16484
      Conserved Domains (3) summary
      cd02334
      Location:243291
      Blast Score: 231
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:19139
      Blast Score: 448
      efhand_1; EF hand
      pfam09069
      Location:143234
      Blast Score: 421
      efhand_2; EF-hand
    15. NM_004020.3NP_004011.2  dystrophin Dp140c isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp140 transcripts use exons 45-79, starting at a promoter/exon 1 located in intron 44. Dp140 transcripts have a long (1 kb) 5' UTR since translation is initiated in exon 51 (corresponding to aa 2461 of dystrophin). In addition to the alternative promoter and exon 1, differential splicing of exons 71-74 and 78 produces at least five Dp140 isoforms. Of these, this transcript (Dp140c) lacks exons 71-74.
      Source sequence(s)
      AC078958, BC028720, DA804849, M18533
      Consensus CDS
      CCDS55394.1
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000444119, ENST00000541735
      Conserved Domains (5) summary
      cd00176
      Location:12228
      Blast Score: 204
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:599628
      Blast Score: 116
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:851899
      Blast Score: 267
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:627747
      Blast Score: 449
      efhand_1; EF hand
      pfam09069
      Location:751842
      Blast Score: 416
      efhand_2; EF-hand
    16. NM_004021.2NP_004012.1  dystrophin Dp140b isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp140 transcripts use exons 45-79, starting at a promoter/exon 1 located in intron 44. Dp140 transcripts have a long (1 kb) 5' UTR since translation is initiated in exon 51 (corresponding to aa 2461 of dystrophin). In addition to the alternative promoter and exon 1, differential splicing of exons 71-74 and 78 produces at least five Dp140 isoforms. Of these, this transcript (Dp140b) lacks exon 78 and encodes a protein with a unique C-terminus.
      Source sequence(s)
      BC028720, DA804849, M18533
      UniProtKB/TrEMBL
      A7E212
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000417123, OTTHUMP00000215846, ENST00000474231, OTTHUMT00000356267
      Conserved Domains (5) summary
      cd00176
      Location:12228
      Blast Score: 206
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:599628
      Blast Score: 117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:851899
      Blast Score: 267
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:627747
      Blast Score: 451
      efhand_1; EF hand
      pfam09069
      Location:751842
      Blast Score: 416
      efhand_2; EF-hand
    17. NM_004022.2NP_004013.1  dystrophin Dp140ab isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp140 transcripts use exons 45-79, starting at a promoter/exon 1 located in intron 44. Dp140 transcripts have a long (1 kb) 5' UTR since translation is initiated in exon 51 (corresponding to aa 2461 of dystrophin). In addition to the alternative promoter and exon 1, differential splicing of exons 71-74 and 78 produces at least five Dp140 isoforms. Of these, this transcript (Dp140ab) lacks exons 71 and 78 and encodes a protein with a unique C-terminus.
      Source sequence(s)
      BC028720, DA804849, M18533, M92650
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000352894, ENST00000359836
      Conserved Domains (5) summary
      cd00176
      Location:12228
      Blast Score: 204
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:599628
      Blast Score: 117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:851899
      Blast Score: 267
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:627747
      Blast Score: 450
      efhand_1; EF hand
      pfam09069
      Location:751842
      Blast Score: 416
      efhand_2; EF-hand
    18. NM_004023.2NP_004014.1  dystrophin Dp140bc isoform

      Status: REVIEWED

      Description
      Transcript Variant: Dp140 transcripts use exons 45-79, starting at a promoter/exon 1 located in intron 44. Dp140 transcripts have a long (1 kb) 5' UTR since translation is initiated in exon 51 (corresponding to aa 2461 of dystrophin). In addition to the alternative promoter and exon 1, differential splicing of exons 71-74 and 78 produces at least five Dp140 isoforms. Of these, this transcript (Dp140bc) lacks exons 71-74 and 78 and encodes a protein with a unique C-terminus.
      Source sequence(s)
      BC028720, DA804849, M18533, M92650
      UniProtKB/Swiss-Prot
      P11532
      Related
      ENSP00000340057, ENST00000343523
      Conserved Domains (5) summary
      cd00176
      Location:12228
      Blast Score: 203
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:599628
      Blast Score: 117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:851899
      Blast Score: 268
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:627747
      Blast Score: 449
      efhand_1; EF hand
      pfam09069
      Location:751842
      Blast Score: 415
      efhand_2; EF-hand

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      31137345..33357726, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      28877768..31095562, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB037493.1 BAA90413.1
    genomic AC004468.1 (1..125755) None
    genomic AC006061.1 (90999..98055) None
    genomic AC078957.16 (1..196998) None
    genomic AC078958.30 (2001..187545) None
    genomic AC079143.17 (1998..5302) None
    genomic AC079175.24 (1..161197) None
    genomic AC079177.21 (2008..155532) None
    genomic AC079864.22 (1569..161873) None
    genomic AC090632.13 None
    genomic AC093167.11 (2071..75000) None
    genomic AC093193.11 (2646..83000) None
    genomic AC096506.5 (2006..120134) None
    genomic AF047502.1 AAD03808.1
    genomic AF047505.1 AAD03809.1
    genomic AF213402.1 AAL61550.1
    genomic AF213403.1 AAL61551.1
    genomic AF213404.1 AAL61552.1
    genomic AF213405.1 AAL61553.1
    genomic AF213406.1 AAL61554.1
    genomic AF213407.1 AAL61555.1
    genomic AF213408.1 AAL61556.1
    genomic AF213409.1 AAL61557.1
    genomic AF213410.1 AAL61558.1
    genomic AF213411.1 AAL61559.1
    genomic AF213412.1 AAL65098.1
    genomic AF213413.1 AAL61560.1
    genomic AF213414.1 AAL61561.1
    genomic AF213415.1 AAL61562.1
    genomic AF213416.1 AAL61563.1
    genomic AF213417.1 AAL61564.1
    genomic AF213418.1 AAL61565.1
    genomic AF213419.1 AAL61566.1
    genomic AF213420.1 AAL61567.1
    genomic AF213421.1 AAL61568.1
    genomic AF213422.1 AAL61569.1
    genomic AF213423.1 AAL61570.1
    genomic AF213424.1 AAL61571.1
    genomic AF213425.1 AAL61572.1
    genomic AF213426.1 AAL61573.1
    genomic AF213427.1 AAL61574.1
    genomic AF213428.1 AAL61575.1
    genomic AF213429.1 AAL61576.1
    genomic AF213430.1 AAL61577.1
    genomic AF213431.1 AAL61578.1
    genomic AF213433.1 AAL61579.1
    genomic AF213434.1 AAL61580.1
    genomic AF213435.1 AAL65099.1
    genomic AF213436.1 AAL65100.1
    genomic AF213437.1 AAL61581.1
    genomic AF213438.1 AAL61582.1
    genomic AF213439.1 AAL61583.1
    genomic AF213440.1 AAL61584.1
    genomic AF213441.1 AAL61585.1
    genomic AF213442.1 AAL61586.1
      AAL61587.1
    genomic AF213443.1 AAL61588.1
    genomic AF213444.1 AAL61589.1
    genomic AJ271220.2 CAD30261.1
    genomic AL031542.1 CAI42228.1
      CAI42229.1
      CAI42230.1
    genomic AL031643.1 CAI43056.1
      CAI43057.1
      CAI43058.1
    genomic AL049643.12 CAI43007.1
    genomic AL050305.9 CAI42099.1
    genomic AL096699.11 CAI42224.1
      CAI42225.1
      CAI42226.1
      CAI42227.1
    genomic AL096699.11 CAI42224.1
      CAI42225.1
      CAI42226.1
      CAI42227.1
    genomic AL109609.5 CAI42948.1
      CAI42949.1
      CAI42950.1
    genomic AL121880.21 (100..87064) None
    genomic AL139278.12 CAI42991.1
    genomic AL139401.14 (100..16391) None
    genomic AL451144.5 CAI39563.1
      CAI39564.1
      CAI39565.1
      CAI39566.1
      CAI39567.1
    genomic AL596023.2 (2000..3995) None
    genomic CH471074.1 EAW99061.1
      EAW99062.1
      EAW99063.1
      EAW99064.1
      EAW99065.1
      EAW99066.1
    genomic D32048.1 None
    genomic L01538.1 None
    genomic L05642.1 AAA74506.1
    genomic L05646.1 AAA74507.1
    genomic L05649.1 AAA74508.1
    genomic M23261.1 AAA52309.1
    genomic M32058.1 None
    genomic M81257.1 AAA52330.1
    genomic M86903.1 AAA35779.1
    genomic S42212.1 AAD13821.1
    genomic U27203.1 AAA86115.1
      AAA86116.1
    genomic U60822.1 AAC51631.1
    genomic U90310.1 None
    genomic U94396.1 AAB53001.1
    genomic X06293.1 CAE82077.1
    genomic X13045.1 CAA31451.1
    genomic X13046.1 CAA31452.1
    genomic X13047.1 CAA31453.1
    genomic X13048.1 CAA31454.1
    genomic X15495.1 CAA33518.1
    genomic X54820.1 CAA38589.1
    mRNA AB208836.1 BAD92073.1
    mRNA AK129855.1 None
    mRNA AK299936.1 BAG61769.1
    mRNA AK309142.1 None
    mRNA BC009242.2 AAH09242.1
    mRNA BC010932.1 None
    mRNA BC028720.1 AAH28720.1
    mRNA BC036103.1 AAH36103.1
    mRNA BC070078.1 AAH70078.1
    mRNA BC094758.1 AAH94758.1
    mRNA BC127103.1 AAI27104.2
    mRNA BC150141.1 AAI50142.1
    mRNA DA804849.1 None
    mRNA DB233002.1 None
    mRNA L35854.1 None
    mRNA M18533.1 AAA53189.1
    mRNA M63072.1 AAA52312.1
    mRNA M63073.1 AAA52313.1
    mRNA M63074.1 AAA52314.1
    mRNA M63075.1 AAA52315.1
    mRNA M92650.1 AAA52316.1
    mRNA S38776.1 AAB22395.2
    mRNA S42206.1 AAD13820.1
    mRNA S60970.1 None
    mRNA S60971.1 None
    mRNA S60972.1 None
    mRNA S60973.1 None
    mRNA S62617.1 AAB27159.1
    mRNA S64152.1 None
    mRNA S81419.1 AAD14363.1
    mRNA X06178.1 CAA29544.1
    mRNA X06179.1 CAA29545.1
    mRNA X14298.1 CAA32479.1
    mRNA X15148.1 CAA33245.1
    mRNA X15149.1 CAA33246.1
    other-genetic BC111587.2 AAI11588.1
    other-genetic BC111836.3 AAI11837.1
    other-genetic BC111934.1 AAI11935.1
    other-genetic BC118002.1 AAI18003.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11532.3 GenPept UniProtKB/Swiss-Prot:P11532
    Q08947 GenPept UniProtKB/TrEMBL:Q08947
    Q14172 GenPept UniProtKB/TrEMBL:Q14172
    Q14174 GenPept UniProtKB/TrEMBL:Q14174
    Q14205 GenPept UniProtKB/TrEMBL:Q14205
    Q15945 GenPept UniProtKB/TrEMBL:Q15945
    Q16428 GenPept UniProtKB/TrEMBL:Q16428
    Q16484 GenPept UniProtKB/TrEMBL:Q16484
    Q548X2 GenPept UniProtKB/TrEMBL:Q548X2
    Q59HC3 GenPept UniProtKB/TrEMBL:Q59HC3
    Q6NSJ9 GenPept UniProtKB/TrEMBL:Q6NSJ9
    Q6PK12 GenPept UniProtKB/TrEMBL:Q6PK12
    Q7KYP7 GenPept UniProtKB/TrEMBL:Q7KYP7
    Q7KZ40 GenPept UniProtKB/TrEMBL:Q7KZ40
    Q8TCV2 GenPept UniProtKB/TrEMBL:Q8TCV2
    Q8WTQ2 GenPept UniProtKB/TrEMBL:Q8WTQ2
    Q8WYB7 GenPept UniProtKB/TrEMBL:Q8WYB7
    Q8WYB8 GenPept UniProtKB/TrEMBL:Q8WYB8
    Q8WYB9 GenPept UniProtKB/TrEMBL:Q8WYB9
    Q8WYC0 GenPept UniProtKB/TrEMBL:Q8WYC0
    Q8WYC1 GenPept UniProtKB/TrEMBL:Q8WYC1
    Q8WYC2 GenPept UniProtKB/TrEMBL:Q8WYC2
    Q8WYC3 GenPept UniProtKB/TrEMBL:Q8WYC3
    Q8WYC4 GenPept UniProtKB/TrEMBL:Q8WYC4
    Q8WYC5 GenPept UniProtKB/TrEMBL:Q8WYC5
    Q8WYC6 GenPept UniProtKB/TrEMBL:Q8WYC6
    Q8WYC7 GenPept UniProtKB/TrEMBL:Q8WYC7
    Q8WYC8 GenPept UniProtKB/TrEMBL:Q8WYC8
    Q8WYC9 GenPept UniProtKB/TrEMBL:Q8WYC9
    Q8WYD0 GenPept UniProtKB/TrEMBL:Q8WYD0
    Q8WYD1 GenPept UniProtKB/TrEMBL:Q8WYD1
    Q8WYD2 GenPept UniProtKB/TrEMBL:Q8WYD2
    Q8WYD3 GenPept UniProtKB/TrEMBL:Q8WYD3
    Q8WYD4 GenPept UniProtKB/TrEMBL:Q8WYD4
    Q8WYD5 GenPept UniProtKB/TrEMBL:Q8WYD5
    Q8WYD6 GenPept UniProtKB/TrEMBL:Q8WYD6
    Q8WYD7 GenPept UniProtKB/TrEMBL:Q8WYD7
    Q8WYD8 GenPept UniProtKB/TrEMBL:Q8WYD8
    Q8WYD9 GenPept UniProtKB/TrEMBL:Q8WYD9
    Q8WYE0 GenPept UniProtKB/TrEMBL:Q8WYE0
    Q8WYE1 GenPept UniProtKB/TrEMBL:Q8WYE1
    Q8WYE2 GenPept UniProtKB/TrEMBL:Q8WYE2
    Q8WYE3 GenPept UniProtKB/TrEMBL:Q8WYE3
    Q8WYE4 GenPept UniProtKB/TrEMBL:Q8WYE4
    Q8WYE5 GenPept UniProtKB/TrEMBL:Q8WYE5
    Q8WYE6 GenPept UniProtKB/TrEMBL:Q8WYE6
    Q8WYE7 GenPept UniProtKB/TrEMBL:Q8WYE7
    Q8WYE8 GenPept UniProtKB/TrEMBL:Q8WYE8
    Q8WYE9 GenPept UniProtKB/TrEMBL:Q8WYE9
    Q8WYF0 GenPept UniProtKB/TrEMBL:Q8WYF0
    Q8WYF1 GenPept UniProtKB/TrEMBL:Q8WYF1
    Q8WYF2 GenPept UniProtKB/TrEMBL:Q8WYF2
    Q8WYF3 GenPept UniProtKB/TrEMBL:Q8WYF3
    Q8WYF4 GenPept UniProtKB/TrEMBL:Q8WYF4
    Q8WYF5 GenPept UniProtKB/TrEMBL:Q8WYF5
    Q8WYF6 GenPept UniProtKB/TrEMBL:Q8WYF6
    Q9UEH4 GenPept UniProtKB/TrEMBL:Q9UEH4
    Q9UME2 GenPept UniProtKB/TrEMBL:Q9UME2
    Q9UMG1 GenPept UniProtKB/TrEMBL:Q9UMG1
    Q9UMK6 GenPept UniProtKB/TrEMBL:Q9UMK6
    Q9UMK7 GenPept UniProtKB/TrEMBL:Q9UMK7
    Q9UMK8 GenPept UniProtKB/TrEMBL:Q9UMK8
    Q9UPB4 GenPept UniProtKB/TrEMBL:Q9UPB4
    Q9UPB5 GenPept UniProtKB/TrEMBL:Q9UPB5

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