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rpl-3 60S ribosomal protein L3;Large ribosomal subunit protein uL3 [ Caenorhabditis elegans ]

Gene ID: 175501, updated on 23-Nov-2023

Summary

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Gene symbol
rpl-3
Gene description
60S ribosomal protein L3;Large ribosomal subunit protein uL3
Primary source
WormBase:WBGene00004414
Locus tag
CELE_F13B10.2
See related
AllianceGenome:WB:WBGene00004414
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal large subunit assembly. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to several human genes including RPL3 (ribosomal protein L3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (3867854..3869587)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Breast cancer type 1 susceptibility protein homolog Neighboring gene Acetyl-coenzyme A synthetase Neighboring gene ncRNA Neighboring gene ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1 Neighboring gene putative methylmalonyl-CoA mutase, mitochondrial

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Mitrovich QM, et al. Genes Dev, 2000 Sep 1. PMID 10970881, Free PMC Article
  2. Rates of deleterious mutation and the evolution of sex in Caenorhabditis. Cutter AD, et al. J Evol Biol, 2003 Sep. PMID 14635896
  3. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Pal S, et al. Curr Biol, 2017 Mar 20. PMID 28285997
  4. Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex. Havrylenko S, et al. J Biol Chem, 2011 Aug 12. PMID 21685384, Free PMC Article
  5. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
60S ribosomal protein L3;Large ribosomal subunit protein uL3
NP_001021254.1
  • Confirmed by transcript evidence
NP_001021255.1
  • Confirmed by transcript evidence
NP_001021256.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3867854..3869587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026083.7 → NP_001021254.1  Large ribosomal subunit protein uL3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021254.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P50880
    Conserved Domains (2) summary
    PTZ00103
    Location:1 → 397
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:3 → 372
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

  2. NM_001026084.7 → NP_001021255.1  60S ribosomal protein L3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021255.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECE5
    Conserved Domains (2) summary
    PTZ00103
    Location:1 → 349
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:3 → 324
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

  3. NM_001026085.5 → NP_001021256.1  60S ribosomal protein L3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEC0
    Conserved Domains (2) summary
    PTZ00103
    Location:1 → 299
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:28 → 274
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_002368.3 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50880.1

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