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    daf-2 abnormal DAuer Formation [ Caenorhabditis elegans ]

    Gene ID: 175410, updated on 6-May-2012

    Summary

    Gene symbol
    daf-2
    Gene description
    abnormal DAuer Formation
    Primary source
    WormBase:WBGene00000898
    Locus tag
    Y55D5A.5
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

    Genomic context

    Location :
    chromosome: III
    Sequence :
    Chromosome: III; NC_003281.8 (2995753..3028790, complement)
    See daf-2 in MapViewer

    Chromosome III - NC_003281.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene CUTiclin-Like Neighboring gene hypothetical protein

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:40655 BioGRID:46760 B0280.10    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41206 B0280.9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40802 B0284.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40795 B0285.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41244 B0361.9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41006 C05D2.8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40773 C16C10.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40908 C27F2.10    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:47810 C28A5.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40951 C34E10.8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:48072 C35D10.13    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40920 C45G9.9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40996 F09F7.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40995 F09F7.4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:49105 F10F2.4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37286 F23C8.6    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40876 F26A1.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:49732 F26A1.13    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:49730 F26A1.9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40748 F37A8.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41222 F37C12.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38090 F43G9.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40980 F48E8.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:532355 F52C9.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40076 F54D5.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41249 F56C9.11    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41216 K04G7.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40937 K10D2.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:532131 M01F1.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40828 M88.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40983 R02F2.7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40807 R07E5.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40813 R07E5.7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:56599 R144.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:52584 R151.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:52714 T04A8.11    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:532519 T04A8.7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40786 T08A11.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40936 T10F2.4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:53190 T15B12.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41264 T20B12.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:53292 T20B12.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41260 T20B12.7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41235 T20H4.5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:532828 W03F8.10    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37154 Y65B4A.3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40944 ZC155.4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39207 ZK546.14    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45965 adm-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40841 asb-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40947 atp-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45907 bar-1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:40655 BioGRID:40836 beta-transducin    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40770 ccdc-55    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38255 cco-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40824 cct-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37805 cdc-25.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41269 cgh-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:533239 chk-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39593 cki-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37699 cpb-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41274 cux-7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38017 cyc-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37847 cye-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45821 daf-9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45988 dao-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40792 dcn-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46109 dpy-22    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45937 dpy-7    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:57341 dsh-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:49297 efn-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46202 egl-15    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41519 emb-30    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40856 emb-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40941 emb-8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46455 eor-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:43057 epi-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41224 exos-9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:566642 fipr-18    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38285 fog-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37974 gld-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40934 grs-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38546 gsk-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41110 hmg-1.2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41261 hmg-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38723 hmp-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40254 hpr-17    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38481 hsf-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39428 icd-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40821 ins-17    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45903 ist-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:42664 itr-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46004 ksr-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:42495 lag-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45905 lam-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37550 let-502    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:53293 lgc-50    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40134 lin-29    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37704 lin-35    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37962 lrp-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40843 mab-21    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40789 mcm-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40915 mdt-11    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37825 mei-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39808 mel-11    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37111 mex-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40997 mlc-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40895 mmab-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41259 mml-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40398 mog-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39264 mog-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:44258 mom-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41624 mua-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41268 mup-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:56214 nhr-9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:44789 nid-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40685 npp-9    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41213 nuo-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46380 odr-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40872 pal-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40832 pan-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:43208 par-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38534 par-6    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40742 pat-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:56678 pdcd-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40712 pdi-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45314 pha-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37780 pnk-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37329 pop-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:48030 pph-6    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39719 prx-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41238 psd-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40850 ribonuleoprotein    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40762 rnr-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40901 rpb-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40894 rpb-8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40739 rpl-3    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41227 rpl-6    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40862 rps-0    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41218 rps-14    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41223 rps-21    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:44099 scd-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:46311 sdz-19    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40704 sel-8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:45979 sem-5    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41432 sma-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:57309 smo-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40175 sop-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38145 spd-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38249 sur-6    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40756 tbb-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41263 tbp-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40929 tbx-2    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41001 ucr-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40935 ulp-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:41706 unc-119    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:37690 unc-40    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40407 unc-52    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:38623 vps-28    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39429 vps-32.1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:54226 vps-4    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40914 wip-1    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:40957 ztf-8    BioGRID  PubMed Negative Genetic 
    BioGRID:40655 BioGRID:39679 zyg-9    BioGRID  PubMed Negative Genetic 

    General gene information

    Markers

    Homology

    • Homologs of the daf-2 gene: The daf-2 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito.

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    insulin-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dauer exit IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
     
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription factor import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription factor import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    regulation of development, heterochronic IGI
    Inferred from Genetic Interaction
    more info
     
    reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Names
    abnormal DAuer Formation family member (daf-2)

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.8

      Range
      2995753..3028790, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065249.3NP_497650.3  abnormal DAuer Formation family member (daf-2) [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (5) summary
      cd00063
      Location:10841170
      Blast Score: 103
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05032
      Location:12361519
      Blast Score: 1299
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:12431517
      Blast Score: 901
      STYKc; Protein kinase; unclassified specificity.
      pfam00757
      Location:357492
      Blast Score: 292
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:177302
      Blast Score: 281
      Recep_L_domain; Receptor L domain
    2. NM_001129262.2NP_001122734.1  abnormal DAuer Formation family member (daf-2) [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd00063
      Location:773829
      Blast Score: 105
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:357492
      Blast Score: 276
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:177302
      Blast Score: 276
      Recep_L_domain; Receptor L domain

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC084196.1 AAK29947.2
    genomic BX284603.2 AAK29947.2
    genomic AC084196.1 ACH98486.1
    genomic BX284603.2 ACH98486.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q968Y9.1 GenPept

      Supplemental Content