Mre11a meiotic recombination 11 homolog A (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Mre11aprovided by MGI
Official Full Name: meiotic recombination 11 homolog A (S. cerevisiae)provided by MGI
Primary source: MGI:1100512
Locus tag: RP23-149D5.3
See related: Ensembl:ENSMUSG00000031928; Vega:OTTMUSG00000031684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mre11; Mre11b

Genomic context

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Location :: 9 A2; 9

Sequence :: Chromosome: 9; NC_000075.6 (14784707..14834417)

See Mre11a in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that the MRE11-RAD50 complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses
Title: DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR/CHK1 checkpoint signaling.
Title: The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.
Mre11 is present in mitochondria where it binds to mtDNA and that the amount in mitochondria varies depending on cellular stress and differentiation.
Title: Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.
Data show that CS-mediated SCC lethality was mitigated in irradiated gain-of-function Rad50(s/s) mice, and epistasis studies order Rad50 upstream of Mre11.
Title: Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
Title: MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
the Mre11 complex influences the cellular response to telomere dysfunction, reminiscent of its influence on the response to interstitial DNA breaks
Title: The mre11 complex and the response to dysfunctional telomeres.
The role of Mre11/Rad50/Nbs1 at dysfunctional telomeres is multifaceted, involving both repression of NHEJ in G(2) through end resection and induction of NHEJ in G(1) through ATM-dependent signaling.
Title: Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Results suggest a model in which MRN stabilizes distant breaks and processes DNA termini to facilitate repair by both the classical and alternative NHEJ pathways.
Title: Multiple functions of MRN in end-joining pathways during isotype class switching.
Data show that depletion of Mre11 reduces the use of microhomology during NHEJ in Xrcc4(+/+) cells and suppresses end resection in Xrcc4(-/-) cells, revealing specific roles for Mre11 in both classical and alternative NHEJ.
Title: Role of mammalian Mre11 in classical and alternative nonhomologous end joining.
data indicate a critical role for the MRN complex in sensing dysfunctional telomeres, and show that in the absence of TRF2, MRE11 nuclease activity removes the 3' telomeric overhang to promote chromosome fusions
Title: Multiple roles for MRE11 at uncapped telomeres.

Submit: New GeneRIF Correction See all (18)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Targeted (knock-in) (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:201486	BioGRID:201372	Mdm2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201486	BioGRID:205163	Nbn	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201486	BioGRID:202371	Prkdc	BioGRID	PubMed	Synthetic Lethality

Pathways from BioSystems

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Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem (from REACTOME)
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystemcomputationally inferred pathway (not manually curated)
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
Double-Strand Break Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Homologous Recombination Repair, organism-specific biosystem (from REACTOME)
Homologous Recombination Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Homologous recombination, organism-specific biosystem (from WikiPathways)
Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
Homologous recombination, organism-specific biosystem (from KEGG)
Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Homologous recombination, conserved biosystem (from KEGG)
Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystem (from REACTOME)
Homologous recombination repair of replication-independent double-strand breaks, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MRN complex, organism-specific biosystem (from KEGG)
MRN complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
MRN complex relocalizes to nuclear foci, organism-specific biosystem (from REACTOME)
MRN complex relocalizes to nuclear foci, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Non-homologous end joining, organism-specific biosystem (from WikiPathways)
Non-homologous end joining, organism-specific biosystem(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because...
Non-homologous end-joining, organism-specific biosystem (from KEGG)
Non-homologous end-joining, organism-specific biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
Non-homologous end-joining, conserved biosystem (from KEGG)
Non-homologous end-joining, conserved biosystemNonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX c...
Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystem (from REACTOME)
Recruitment of repair and signaling proteins to double-strand breaks, organism-specific biosystemcomputationally inferred pathway (not manually curated)
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236059

U60318 (e-PCR)
- UniSTS:163453

Homology

Homologs of the Mre11a gene: The Mre11a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ATP-dependent DNA helicase activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
endonuclease activity	IEA Inferred from Electronic Annotation more info
exonuclease activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
manganese ion binding	IEA Inferred from Electronic Annotation more info
nuclease activity	IEA Inferred from Electronic Annotation more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
DNA metabolic process	IEA Inferred from Electronic Annotation more info
DNA repair	IEA Inferred from Electronic Annotation more info
cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
intra-S DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
meiosis	IEA Inferred from Electronic Annotation more info
mitotic G2 DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of DNA endoreduplication	ISO Inferred from Sequence Orthology more info
positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info	PubMed
sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
synapsis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Mre11 complex	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
nuclear chromatin	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: double-strand break repair protein MRE11A

Names: double-strand break repair protein MRE11A; mmMRE11A; MRE11 homolog 1; MRE11 homolog A; meiotic recombination 11 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018736.2 → NP_061206.1 double-strand break repair protein MRE11A

Status: PROVISIONAL

Source sequence(s)

BC065144

Consensus CDS

CCDS22827.1

UniProtKB/TrEMBL

Q3URU4

UniProtKB/Swiss-Prot

Q61216

Related

ENSMUSP00000034405, OTTMUSP00000041737, ENSMUST00000034405, OTTMUST00000078494

Conserved Domains (3) summary

TIGR00583
Location:10 – 402
Blast Score: 1287

mre11; DNA repair protein (mre11)

cd00840
Location:14 – 275
Blast Score: 522

MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain

pfam04152
Location:294 – 462
Blast Score: 524

Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

14784707..14834417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

12065444..12115180

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01076179.1 (25398..37141)	None
genomic	AAHY01076180.1	None
genomic	AC136743.5 (108532..124442)	None
genomic	CH466522.1	EDL25006.1	mixed
		EDL25007.1	mixed
		EDL25008.1	mixed
genomic	CT030247.6	None
mRNA	AK041248.1	BAC30878.1	C57BL/6J
mRNA	AK141214.1	BAE24593.1	C57BL/6J
mRNA	AK146234.1	BAE27000.1	DBA/2
mRNA	AK146370.1	BAE27119.1	DBA/2
mRNA	AK161013.1	BAE36147.1	C57BL/6J
mRNA	AK168180.1	BAE40140.1	DBA/2
mRNA	AK168208.1	None	DBA/2
mRNA	BC065144.1	AAH65144.1	C57BL/6
mRNA	U58987.1	AAB04955.1	CD-1
mRNA	U60318.1	AAB03664.1	CD-1