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ddp-1 Mitochondrial import inner membrane translocase subunit Tim8 [ Caenorhabditis elegans ]

Gene ID: 175331, updated on 23-Nov-2023

Summary

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Gene symbol
ddp-1
Gene description
Mitochondrial import inner membrane translocase subunit Tim8
Primary source
WormBase:WBGene00000941
Locus tag
CELE_Y39A3CR.4
See related
AllianceGenome:WB:WBGene00000941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Involved in mitochondrion organization. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Used to study deafness-dystonia-optic neuronopathy syndrome. Human ortholog(s) of this gene implicated in deafness-dystonia-optic neuronopathy syndrome and dystonia. Orthologous to several human genes including TIMM8A (translocase of inner mitochondrial membrane 8A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003281.10 (1859888..1860381)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene BHLH domain-containing protein Neighboring gene ncRNA Neighboring gene TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 7 N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. Curran SP, et al. J Biol Chem, 2004 Dec 24. PMID 15485840
  2. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Kirstein-Miles J, et al. Dev Dyn, 2010 May. PMID 20419784, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial import inner membrane translocase subunit Tim8
NP_497467.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    1859888..1860381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065066.6 → NP_497467.1  Mitochondrial import inner membrane translocase subunit Tim8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497467.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N408, Q9Y0V8
    Conserved Domains (1) summary
    pfam02953
    Location:13 → 75
    zf-Tim10_DDP; Tim10/DDP family zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N408.1

Gene LinkOut

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