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vha-4 V-type proton ATPase 21 kDa proteolipid subunit c'' [ Caenorhabditis elegans ]

Gene ID: 174272, updated on 11-Apr-2024

Summary

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Gene symbol
vha-4
Gene description
V-type proton ATPase 21 kDa proteolipid subunit c''
Primary source
WormBase:WBGene00006913
Locus tag
CELE_T01H3.1
See related
AllianceGenome:WB:WBGene00006913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton transmembrane transporter activity. Involved in embryo development. Predicted to be located in membrane. Predicted to be part of proton-transporting two-sector ATPase complex, proton-transporting domain. Predicted to be integral component of membrane. Is expressed in excretory cell and rectum. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (7878082..7879316, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene Peroxin/Ferlin domain-containing protein Neighboring gene ncRNA Neighboring gene XH domain-containing protein Neighboring gene Epimerase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. Oka T, et al. J Biol Chem, 2000 Sep 22. PMID 10846178
  2. Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells. Oka T, et al. J Biol Chem, 1997 Sep 26. PMID 9305897
  3. Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. Oka T, et al. J Biol Chem, 1998 Aug 28. PMID 9712884
  4. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka T, et al. J Biol Chem, 2001 Aug 31. PMID 11441002
  5. The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. Liégeois S, et al. J Cell Biol, 2006 Jun 19. PMID 16785323, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase 21 kDa proteolipid subunit c''
NP_495659.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7878082..7879316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063258.9 → NP_495659.1  V-type proton ATPase 21 kDa proteolipid subunit c'' [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDB8
    Conserved Domains (1) summary
    pfam00137
    Location:54 → 114
    ATP-synt_C; ATP synthase subunit C
Nucleotide Protein
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