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glr-4 GLutamate Receptor family (AMPA) [ Caenorhabditis elegans ]

Gene ID: 174258, updated on 23-Nov-2023

Summary

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Gene symbol
glr-4
Gene description
GLutamate Receptor family (AMPA)
Primary source
WormBase:WBGene00001615
Locus tag
CELE_C06A8.9
See related
AllianceGenome:WB:WBGene00001615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in postsynaptic membrane. Is expressed in DVA; body ganglion; cholinergic neurons; and head neurons. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1) and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See glr-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
21
Sequence:
Chromosome: II; NC_003280.10 (7785100..7794322, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Spindly-like protein spdl-1 Neighboring gene Skp1-related protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans. Von Stetina SE, et al. Genes Dev, 2007 Feb 1. PMID 17289921, Free PMC Article
  2. Glutamate receptor channel signatures. Sprengel R, et al. Trends Pharmacol Sci, 2001 Jan. PMID 11165660
  3. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835
  4. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. Brockie PJ, et al. J Neurosci, 2001 Mar 1. PMID 11222641, Free PMC Article
  5. Control of neuronal subtype identity by the C. elegans ARID protein CFI-1. Shaham S, et al. Genes Dev, 2002 Apr 15. PMID 11959845, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-gated receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GLutamate Receptor family (AMPA)
NP_001254126.1
  • Product from WormBase gene class glr;
    Confirmed by transcript evidence
NP_001359784.1
  • Product from WormBase gene class glr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7785100..7794322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373747.3 → NP_001359784.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KY73
    Conserved Domains (2) summary
    cl10011
    Location:30 → 383
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:410 → 775
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

  2. NM_001267197.2 → NP_001254126.1  GLutamate Receptor family (AMPA) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17697
    Conserved Domains (4) summary
    cd06382
    Location:30 → 385
    PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
    pfam00060
    Location:533 → 810
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:45 → 365
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:410 → 775
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
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