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DLG4 discs, large homolog 4 (Drosophila) [ Homo sapiens (human) ]

Gene ID: 1742, updated on 19-Jul-2014
Official Symbol
DLG4provided by HGNC
Official Full Name
discs, large homolog 4 (Drosophila)provided by HGNC
Primary source
HGNC:2903
See related
Ensembl:ENSG00000132535; HPRD:04199; MIM:602887; Vega:OTTHUMG00000134327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSD95; SAP90; SAP-90
Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See DLG4 in Epigenomics, MapViewer
Location:
17p13.1
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (7189890..7220050, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7093209..7123369, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 64 Neighboring gene asialoglycoprotein receptor 1 Neighboring gene acyl-CoA dehydrogenase, very long chain Neighboring gene microRNA 324 Neighboring gene dishevelled segment polarity protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced synapse loss significantly decreases levels of PSD-95 protein by the ubiquitin-proteasome pathway in the puncta PubMed
Tat tat HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface PubMed
tat HIV-1 Tat decreases the scaffolding protein postsynaptic density 95 (PSD95) in synapses via the low-density lipoprotein receptor-related protein (LRP); Tat decreases PSD95 in a concentration-dependent manner PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Activation of Ca-permeable Kainate Receptor, organism-specific biosystem (from REACTOME)
    Activation of Ca-permeable Kainate Receptor, organism-specific biosystemKainate receptors that are assembled with subunits GRIK1-5, are Ca2+ permeable if GRIK1 and GRIK2 are not edited at the Q/R or other sites.These channels permit Ca2+ upon activation by glutamate or o...
  • Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem (from REACTOME)
    Activation of Kainate Receptors upon glutamate binding, organism-specific biosystemKainate receptors are found both in the presynaptc terminals and the postsynaptic neurons. Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the ...
  • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
    Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
  • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB4 signaling events, organism-specific biosystem
    ErbB4 signaling events
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Ionotropic activity of Kainate Receptors, organism-specific biosystem (from REACTOME)
    Ionotropic activity of Kainate Receptors, organism-specific biosystemKainate receptors are either Ca2+ permeable or impermeable depending on the composition of the receptor and the editing status of subunits GluR5 and GluR6 (GRIK1 and 2).
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • NrCAM interactions, organism-specific biosystem (from REACTOME)
    NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...
  • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
    Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
    Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
    Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ97752, FLJ98574

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D1 dopamine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
P2Y1 nucleotide receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
acetylcholine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-1 adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ionotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering TAS
Traceable Author Statement
more info
PubMed 
axon guidance TAS
Traceable Author Statement
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
learning TAS
Traceable Author Statement
more info
PubMed 
locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of N-methyl-D-aspartate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of grooming behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of long-term neuronal synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
social behavior IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
 
synaptic vesicle maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
vocalization behavior IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with ionotropic glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
disks large homolog 4
Names
disks large homolog 4
discs large homolog 4
Tax interaction protein 15
synapse-associated protein 90
postsynaptic density protein 95
post-synaptic density protein 95

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008391.2 

    Range
    5001..35161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128827.1NP_001122299.1  disks large homolog 4 isoform 2

    See proteins identical to NP_001122299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks a 3 amino acid internal segment when compared to isoform 1.
    Source sequence(s)
    AA954439, AK307804, AK308533, BC030203
    Consensus CDS
    CCDS45600.1
    UniProtKB/Swiss-Prot
    P78352
    Related
    ENSP00000307471, OTTHUMP00000166068, ENST00000302955, OTTHUMT00000259420
    Conserved Domains (6) summary
    pfam10608
    Location:1031
    Blast Score: 109
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12030
    Location:427492
    Blast Score: 382
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:533649
    Blast Score: 309
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:308386
    Blast Score: 233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:530708
    Blast Score: 644
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:242309
    Blast Score: 321
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  2. NM_001365.3NP_001356.1  disks large homolog 4 isoform 1 precursor

    See proteins identical to NP_001356.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC120057
    Consensus CDS
    CCDS45599.1
    UniProtKB/Swiss-Prot
    P78352
    Related
    ENSP00000382428, OTTHUMP00000166066, ENST00000399510, OTTHUMT00000259418
    Conserved Domains (7) summary
    pfam10608
    Location:5374
    Blast Score: 110
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12030
    Location:473538
    Blast Score: 382
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:579695
    Blast Score: 310
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:354432
    Blast Score: 235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:576754
    Blast Score: 643
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:288355
    Blast Score: 316
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:2653
    Blast Score: 92
    L27; L27 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    7189890..7220050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256489.1XP_005256546.1  

    See proteins identical to XP_005256546.1

    UniProtKB/TrEMBL
    B9EGL1
    Conserved Domains (7) summary
    pfam10608
    Location:5374
    Blast Score: 110
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12030
    Location:470535
    Blast Score: 382
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:576692
    Blast Score: 310
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:351429
    Blast Score: 235
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:573751
    Blast Score: 643
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:285352
    Blast Score: 316
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:2653
    Blast Score: 92
    L27; L27 domain
  2. XM_005256492.1XP_005256549.1  

    See proteins identical to XP_005256549.1

    UniProtKB/Swiss-Prot
    P78352
    Related
    ENSP00000382425, OTTHUMP00000166067, ENST00000399506, OTTHUMT00000259419
    Conserved Domains (6) summary
    pfam10608
    Location:1031
    Blast Score: 109
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12030
    Location:430495
    Blast Score: 382
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:536652
    Blast Score: 309
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:311389
    Blast Score: 233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:533711
    Blast Score: 644
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    Blast Score: 321
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  3. XM_005256491.1XP_005256548.1  

    See proteins identical to XP_005256548.1

    Conserved Domains (6) summary
    pfam10608
    Location:1031
    Blast Score: 109
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
    cd12030
    Location:460525
    Blast Score: 382
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:566682
    Blast Score: 309
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:341419
    Blast Score: 232
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:563741
    Blast Score: 645
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:275342
    Blast Score: 321
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  4. XM_005256494.1XP_005256551.1  

    See proteins identical to XP_005256551.1

    UniProtKB/TrEMBL
    B7Z647
    Conserved Domains (5) summary
    cd12030
    Location:370435
    Blast Score: 380
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:476592
    Blast Score: 308
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:251329
    Blast Score: 231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:473651
    Blast Score: 642
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    Blast Score: 327
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  5. XM_005256493.2XP_005256550.1  

    See proteins identical to XP_005256550.1

    UniProtKB/TrEMBL
    B7Z647
    Conserved Domains (5) summary
    cd12030
    Location:370435
    Blast Score: 380
    SH3_DLG4; Src Homology 3 domain of Disks Large homolog 4
    cd00071
    Location:476592
    Blast Score: 308
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:251329
    Blast Score: 231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:473651
    Blast Score: 642
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:185252
    Blast Score: 327
    PDZ_assoc; PDZ-associated domain of NMDA receptors

RNA

  1. XR_243545.1 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    6984911..7015359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    7102006..7132134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)