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DLG2 discs large MAGUK scaffold protein 2 [ Homo sapiens (human) ]

Gene ID: 1740, updated on 25-May-2016
Official Symbol
DLG2provided by HGNC
Official Full Name
discs large MAGUK scaffold protein 2provided by HGNC
Primary source
HGNC:HGNC:2901
See related
Ensembl:ENSG00000150672 HPRD:04663; HPRD:08220; MIM:603583; Vega:OTTHUMG00000134309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSD93; PSD-93; PPP1R58; chapsyn-110
Summary
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Orthologs
Location:
11q14.1
Exon count:
39
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (83455012..85628534, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (83166055..85338314, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369420 Neighboring gene cytochrome c, somatic pseudogene 28 Neighboring gene uncharacterized LOC101929043 Neighboring gene uncharacterized LOC105369419 Neighboring gene suppressor of cytokine signaling 6 pseudogene Neighboring gene uncharacterized LOC105369418 Neighboring gene lactate dehydrogenase A like 6D, pseudogene Neighboring gene uncharacterized LOC105369417 Neighboring gene uncharacterized LOC105369416 Neighboring gene ribosomal protein L9 pseudogene 22 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 6 Neighboring gene REST corepressor 1 pseudogene Neighboring gene DEAH-box helicase 9 pseudogene Neighboring gene transmembrane protein 126B Neighboring gene transmembrane protein 126A

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  • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37266, MGC131811, DKFZp781D1854, DKFZp781E0954

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanylate kinase activity TAS
Traceable Author Statement
more info
PubMed 
ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GDP metabolic process IEA
Inferred from Electronic Annotation
more info
 
GMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
NOT establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
NOT basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ionotropic glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
disks large homolog 2
Names
channel-associated protein of synapse-110
channel-associated protein of synapses, 110kDa
discs large 2
discs large homolog 2
discs, large homolog 2
discs, large homolog 2, chapsyn-110
postsynaptic density protein PSD-93
protein phosphatase 1, regulatory subunit 58

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021375.1 RefSeqGene

    Range
    5001..2177260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142699.1NP_001136171.1  disks large homolog 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP003026, BM678399, CR749820
    Consensus CDS
    CCDS44690.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000365272, OTTHUMP00000165971, ENST00000376104, OTTHUMT00000259245
    Conserved Domains (6) summary
    cd12032
    Location:639712
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:787903
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:524602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:784962
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:383450
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:327
    L27; L27 domain
  2. NM_001142700.1NP_001136172.1  disks large homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001136172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a distinct 5' UTR and coding region, lacks three coding exons, and includes an alternate coding exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK126776, AP003026, BM678399
    Consensus CDS
    CCDS44691.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000402275, OTTHUMP00000235335, ENST00000418306, OTTHUMT00000393436
    Conserved Domains (5) summary
    cd12032
    Location:431504
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:561677
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:316394
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:558736
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:227290
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  3. NM_001142702.1NP_001136174.1  disks large homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_001136174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate splice pattern in the central coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus and differs at an internal segment, compared to isoform 1.
    Source sequence(s)
    AK126776, AP003026, BM678399, CR933674, DC303204
    Consensus CDS
    CCDS44692.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000393049, OTTHUMP00000235334, ENST00000426717, OTTHUMT00000393435
    Conserved Domains (3) summary
    cd00071
    Location:146262
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    pfam00625
    Location:143321
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:1689
    SH3; Src Homology 3 domain superfamily
  4. NM_001206769.1NP_001193698.1  disks large homolog 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. Isoform 5 has a distinct N-terminus and is compared to isoform 1.
    Source sequence(s)
    AC023118, AP000773, AP002370, AP002751, AP002797, AP003026, AP003305
    Consensus CDS
    CCDS55782.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000280241, ENST00000280241
    Conserved Domains (5) summary
    cd12032
    Location:573646
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:721837
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:458536
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:718896
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:317384
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  5. NM_001300983.1NP_001287912.1  disks large homolog 2 isoform 6

    See identical proteins and their annotated locations for NP_001287912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK295094, AP003026
    Consensus CDS
    CCDS73357.1
    UniProtKB/TrEMBL
    B7Z2T4
    Related
    ENSP00000435849, OTTHUMP00000165978, ENST00000532653, OTTHUMT00000259253
    Conserved Domains (5) summary
    cd12032
    Location:534607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:664780
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:419497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:661839
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278345
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  6. NM_001364.3NP_001355.2  disks large homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001355.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a distinct 5' UTR and coding region, compared to variant 1. The resulting isoform (2), also known as alpha, has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB209252, AP003026, BM678399, CR749820, DA778233
    Consensus CDS
    CCDS41696.1
    UniProtKB/Swiss-Prot
    Q15700
    Related
    ENSP00000381355, OTTHUMP00000165969, ENST00000398309, OTTHUMT00000259243
    Conserved Domains (5) summary
    cd12032
    Location:534607
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:682798
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:419497
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:679857
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:278345
    PDZ_assoc; PDZ-associated domain of NMDA receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    83455012..85628534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544779.1XP_011543081.1  

    Conserved Domains (6) summary
    cd12032
    Location:676749
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:824940
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:561639
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:821999
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:420487
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:264
    L27; L27 domain
  2. XM_011544781.1XP_011543083.1  

    Conserved Domains (6) summary
    cd12032
    Location:664737
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:812928
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:549627
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:809987
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:408475
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:277
    L27; L27 domain
  3. XM_011544780.1XP_011543082.1  

    Conserved Domains (6) summary
    cd12032
    Location:689762
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:819935
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:574652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:816994
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:433500
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:277
    L27; L27 domain
  4. XM_011544778.1XP_011543080.1  

    Conserved Domains (6) summary
    cd12032
    Location:689762
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:837953
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:574652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:8341012
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:433500
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:277
    L27; L27 domain
  5. XM_011544782.1XP_011543084.1  

    Conserved Domains (5) summary
    cd12032
    Location:555628
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:703819
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:440518
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:700878
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:299366
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  6. XM_011544785.1XP_011543087.1  

    Conserved Domains (5) summary
    cd12032
    Location:530603
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:678794
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:415493
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:675853
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:274341
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  7. XM_011544784.1XP_011543086.1  

    Conserved Domains (5) summary
    cd12032
    Location:533606
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:681797
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:418496
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:678856
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:277344
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  8. XM_005273806.2XP_005273863.1  

    Conserved Domains (5) summary
    cd12032
    Location:554627
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:702818
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:439517
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:699877
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:298365
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  9. XM_011544783.1XP_011543085.1  

    Conserved Domains (5) summary
    cd12032
    Location:553626
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:701817
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:438516
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:698876
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:297364
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  10. XM_006718438.1XP_006718501.1  

    Conserved Domains (5) summary
    cd12032
    Location:492565
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:640756
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:377455
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:637815
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:236303
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  11. XM_011544788.1XP_011543090.1  

    Conserved Domains (5) summary
    cd12032
    Location:449522
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:579695
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:334412
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:576754
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245308
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  12. XM_005273811.3XP_005273868.1  

    Related
    ENSP00000381353, OTTHUMP00000235336, ENST00000330014, OTTHUMT00000393437
    Conserved Domains (5) summary
    cd12032
    Location:501574
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:631747
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:386464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:628806
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  13. XM_005273810.3XP_005273867.1  

    Related
    ENSP00000433848, OTTHUMP00000235338, ENST00000531015, OTTHUMT00000393440
    Conserved Domains (5) summary
    cd12032
    Location:501574
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00071
    Location:649765
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:386464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:646824
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:245312
    PDZ_assoc; PDZ-associated domain of NMDA receptors
  14. XM_011544787.1XP_011543089.1  

    Conserved Domains (5) summary
    cd00071
    Location:599715
    GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
    cd00992
    Location:336414
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:596774
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:195262
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl17036
    Location:451524
    SH3; Src Homology 3 domain superfamily
  15. XM_011544786.1XP_011543088.1  

    Conserved Domains (4) summary
    cd12032
    Location:689762
    SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
    cd00992
    Location:574652
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam10600
    Location:433500
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    cl02672
    Location:277
    L27; L27 domain

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    83050274..85223105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)