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Mllt10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [ Mus musculus (house mouse) ]

Gene ID: 17354, updated on 28-May-2016
Official Symbol
Mllt10provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10provided by MGI
Primary source
MGI:MGI:1329038
See related
Ensembl:ENSMUSG00000026743 Vega:OTTMUSG00000011456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af10; mKIAA4140; B130021D15Rik; D630001B22Rik
Orthologs
Location:
2; 2 A2
Exon count:
30
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (18055175..18212390)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (17976898..18134017)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930004D18 gene Neighboring gene predicted gene, 33085 Neighboring gene predicted gene, 17762 Neighboring gene SKI/DACH domain containing 1 Neighboring gene predicted gene, 39762 Neighboring gene microRNA 7655 Neighboring gene predicted gene, 39761 Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene histone H3.3C-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4140

Gene Ontology Provided by MGI

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
protein AF-10
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252560.1NP_001239489.1  protein AF-10 isoform 1

    See identical proteins and their annotated locations for NP_001239489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL928557, AL928589
    Consensus CDS
    CCDS15708.1
    UniProtKB/Swiss-Prot
    O54826
    Related
    ENSMUSP00000110328, OTTMUSP00000012295, ENSMUST00000114680, OTTMUST00000026949
    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  2. NM_001252561.1NP_001239490.1  protein AF-10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL928557, AL928589
    Consensus CDS
    CCDS57155.1
    UniProtKB/TrEMBL
    A2AS70
    Related
    ENSMUSP00000110319, OTTMUSP00000012236, ENSMUST00000114671, OTTMUST00000026803
    Conserved Domains (1) summary
    cd15708
    Location:3128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  3. NM_010804.4NP_034934.2  protein AF-10 isoform 1

    See identical proteins and their annotated locations for NP_034934.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC070475, BY608946, CN534499, CN537566
    Consensus CDS
    CCDS15708.1
    UniProtKB/Swiss-Prot
    O54826
    Related
    ENSMUSP00000028076, ENSMUST00000028076
    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

RNA

  1. NR_045538.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK045042, AK052207, AL928557, AL928589, BC070475
  2. NR_045539.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL928557, AL928589

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    18055175..18212390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497385.1XP_006497448.1  

    See identical proteins and their annotated locations for XP_006497448.1

    Conserved Domains (1) summary
    cl22851
    Location:187
    PHD_SF; PHD finger superfamily
  2. XM_006497381.2XP_006497444.1  

    See identical proteins and their annotated locations for XP_006497444.1

    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  3. XM_006497384.2XP_006497447.1  

    See identical proteins and their annotated locations for XP_006497447.1

    Conserved Domains (1) summary
    cd15708
    Location:3128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  4. XM_011238961.1XP_011237263.1  

    See identical proteins and their annotated locations for XP_011237263.1

    Conserved Domains (1) summary
    cd15708
    Location:3128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  5. XM_006497386.2XP_006497449.1  

    See identical proteins and their annotated locations for XP_006497449.1

    Conserved Domains (1) summary
    cl22851
    Location:187
    PHD_SF; PHD finger superfamily
  6. XM_006497389.2XP_006497452.1  

    Conserved Domains (1) summary
    cl22851
    Location:184
    PHD_SF; PHD finger superfamily
  7. XM_006497390.2XP_006497453.1  

    Conserved Domains (1) summary
    cl22851
    Location:152
    PHD_SF; PHD finger superfamily
  8. XM_006497391.2XP_006497454.1  

    Conserved Domains (2) summary
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  9. XM_006497372.2XP_006497435.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  10. XM_006497371.2XP_006497434.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  11. XM_006497373.2XP_006497436.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  12. XM_006497375.2XP_006497438.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135260
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  13. XM_006497376.2XP_006497439.1  

    Conserved Domains (2) summary
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cl22851
    Location:138208
    PHD_SF; PHD finger superfamily
  14. XM_006497374.2XP_006497437.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  15. XM_006497382.2XP_006497445.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  16. XM_006497383.2XP_006497446.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cl22851
    Location:135192
    PHD_SF; PHD finger superfamily
  17. XM_006497377.2XP_006497440.1  

    Conserved Domains (3) summary
    sd00025
    Location:123142
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:135263
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  18. XM_006497387.2XP_006497450.1  

    Conserved Domains (1) summary
    cd15574
    Location:81128
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
  19. XM_006497380.1XP_006497443.1  

    See identical proteins and their annotated locations for XP_006497443.1

    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  20. XM_006497378.2XP_006497441.1  

    See identical proteins and their annotated locations for XP_006497441.1

    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  21. XM_006497379.2XP_006497442.1  

    See identical proteins and their annotated locations for XP_006497442.1

    Conserved Domains (3) summary
    sd00025
    Location:6685
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:2471
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  22. XM_011238964.1XP_011237266.1  

    See identical proteins and their annotated locations for XP_011237266.1

    Conserved Domains (1) summary
    cl22851
    Location:187
    PHD_SF; PHD finger superfamily
  23. XM_011238963.1XP_011237265.1  

    See identical proteins and their annotated locations for XP_011237265.1

    Conserved Domains (1) summary
    cl22851
    Location:187
    PHD_SF; PHD finger superfamily
  24. XM_011238962.1XP_011237264.1  

    See identical proteins and their annotated locations for XP_011237264.1

    Conserved Domains (1) summary
    cd15708
    Location:3128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
  25. XM_006497388.2XP_006497451.1  

    Conserved Domains (1) summary
    cl22851
    Location:373
    PHD_SF; PHD finger superfamily

RNA

  1. XR_373934.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    17952263..18109815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)