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Mknk2 MAP kinase-interacting serine/threonine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 17347, updated on 28-May-2016
Official Symbol
Mknk2provided by MGI
Official Full Name
MAP kinase-interacting serine/threonine kinase 2provided by MGI
Primary source
MGI:MGI:894279
See related
Ensembl:ENSMUSG00000020190 Vega:OTTMUSG00000054816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnk2; Gprk7; 2010016G11Rik
Summary
The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Orthologs
Location:
10; 10 C1
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (80665318..80676293, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80128072..80134721, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 2 Neighboring gene BTB (POZ) domain containing 2 Neighboring gene MOB kinase activator 3A Neighboring gene IZUMO family member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 2
Names
G protein-coupled receptor kinase 7
MAP kinase signal-integrating kinase 2
NP_067437.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021462.4NP_067437.2  MAP kinase-interacting serine/threonine-protein kinase 2

    See identical proteins and their annotated locations for NP_067437.2

    Status: REVIEWED

    Source sequence(s)
    AC152410, AK030830, AK164278, BY732164, CX243939
    Consensus CDS
    CCDS24030.2
    UniProtKB/Swiss-Prot
    Q8CDB0
    UniProtKB/TrEMBL
    Q3TPM2
    Related
    ENSMUSP00000143508, OTTMUSP00000071811, ENSMUST00000200082, OTTMUST00000135837
    Conserved Domains (2) summary
    smart00220
    Location:83368
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:81368
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    80665318..80676293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513316.1XP_006513379.1  

    See identical proteins and their annotated locations for XP_006513379.1

    UniProtKB/Swiss-Prot
    Q8CDB0
    Related
    ENSMUSP00000003433, ENSMUST00000003433
    Conserved Domains (2) summary
    smart00220
    Location:83368
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:81368
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    81683700..81694674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)