cdc-37 Hsp90 chaperone protein kinase-targeting subunit;putative Hsp90 co-chaperone cdc37 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cdc-37
Gene description: Hsp90 chaperone protein kinase-targeting subunit;putative Hsp90 co-chaperone cdc37
Primary source: WormBase:WBGene00021097
Locus tag: CELE_W08F4.8
See related: AllianceGenome:WB:WBGene00021097
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable chaperone binding activity; heat shock protein binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding and protein stabilization. Located in condensed chromosome; cytoplasm; and mitotic spindle. Is expressed in anchor cell. Orthologous to several human genes including CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (577839..580593, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90.
Title: Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90.
The N Terminus of CeCdc37 Is Sufficient to Interact with CeHsp90.
Title: Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.
Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
Title: Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.
The ternary Aha1-Cdc37-Hsp90 complex is disrupted by the nucleotide-induced closing reaction at the N terminus of Hsp90.
Title: Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.
CDC-37-mediated inhibition of the CDC-42-dependent binding site and PAR-3-mediated release of this inhibition provide a key mechanism for the anterior accumulation of PAR-6.
Title: Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08F4.8 (e-PCR)
- UniSTS:306311

W08F4.3 (e-PCR)
- UniSTS:318619

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Hsp90 chaperone protein kinase-targeting subunit;putative Hsp90 co-chaperone cdc37

NP_001367479.1

Partially confirmed by transcript evidence

NP_001379645.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

577839..580593 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392995.1 → NP_001379645.1 putative Hsp90 co-chaperone cdc37 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O02108

Conserved Domains (3) summary

smart01071
Location:2 → 123

CDC37_N; Cdc37 N terminal kinase binding

smart01069
Location:292 → 349

CDC37_C; Cdc37 C terminal domain

smart01070
Location:128 → 273

CDC37_M; Cdc37 Hsp90 binding domain
NM_001381317.1 → NP_001367479.1 Hsp90 chaperone protein kinase-targeting subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q336L8

Conserved Domains (3) summary

smart01071
Location:35 → 156

CDC37_N; Cdc37 N terminal kinase binding

smart01069
Location:325 → 382

CDC37_C; Cdc37 C terminal domain

smart01070
Location:161 → 306

CDC37_M; Cdc37 Hsp90 binding domain