U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cup-2 Derlin-1 [ Caenorhabditis elegans ]

Gene ID: 172915, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
cup-2
Gene description
Derlin-1
Primary source
WormBase:WBGene00000843
Locus tag
CELE_F25D7.1
See related
AllianceGenome:WB:WBGene00000843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable misfolded protein binding activity; signal recognition particle binding activity; and ubiquitin-specific protease binding activity. Involved in endocytosis and response to misfolded protein. Located in early endosome and perinuclear endoplasmic reticulum. Is expressed widely. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cup-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (10398990..10400177, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Clathrin-mediated endocytosis is involved in uptake and toxicity of silica nanoparticles in Caenohabditis elegans. Eom HJ, et al. Chem Biol Interact, 2019 Sep 25. PMID 31369748
  2. Derlin-dependent retrograde transport from endosomes to the Golgi apparatus. Dang H, et al. Traffic, 2011 Oct. PMID 21722281, Free PMC Article
  3. RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin. Darom A, et al. Mol Biol Cell, 2010 Jun 1. PMID 20357004, Free PMC Article
  4. The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3. He L, et al. Dis Model Mech, 2012 Nov. PMID 22569626, Free PMC Article
  5. A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Ye Y, et al. Nature, 2004 Jun 24. PMID 15215856

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signal recognition particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signal recognition particle binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Derlin-1
NP_492721.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10398990..10400177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060320.8 → NP_492721.1  Derlin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93561
    Conserved Domains (1) summary
    pfam04511
    Location:10 → 202
    DER1; Der1-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93561.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous