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ZC434.9 ShKT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172908, updated on 11-Apr-2024

Summary

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Gene symbol
ZC434.9
Gene description
ShKT domain-containing protein
Primary source
WormBase:WBGene00013895
Locus tag
CELE_ZC434.9
See related
AllianceGenome:WB:WBGene00013895
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA1 (carboxypeptidase A1); CPA2 (carboxypeptidase A2); and CPA4 (carboxypeptidase A4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
16
Sequence:
Chromosome: I; NC_003279.8 (10356251..10360898)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase Neighboring gene Nicastrin Neighboring gene Cytochrome c oxidase assembly factor 6 homolog;PRORP domain-containing protein Neighboring gene putative arginine kinase ZC434.8 Neighboring gene Specificity protein transcription factor 1 Neighboring gene NEDD8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ShKT domain-containing protein
NP_001021851.2
  • Confirmed by transcript evidence
NP_001021852.2
  • Confirmed by transcript evidence
NP_001251356.1
  • Confirmed by transcript evidence
NP_001251357.1
  • Confirmed by transcript evidence
NP_001251358.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10356251..10360898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026681.4 → NP_001021852.2  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021852.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JLE3
    Conserved Domains (3) summary
    cd03860
    Location:141 → 454
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:486 → 523
    ShK; ShK domain-like
    pfam02244
    Location:45 → 111
    Propep_M14; Carboxypeptidase activation peptide

  2. NM_001264428.4 → NP_001251357.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU28
    Conserved Domains (3) summary
    cd03860
    Location:141 → 454
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:586 → 623
    ShK; ShK domain-like
    pfam02244
    Location:45 → 111
    Propep_M14; Carboxypeptidase activation peptide

  3. NM_001026680.7 → NP_001021851.2  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021851.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23318
    Conserved Domains (3) summary
    cd03860
    Location:141 → 454
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:535 → 572
    ShK; ShK domain-like
    pfam02244
    Location:45 → 111
    Propep_M14; Carboxypeptidase activation peptide

  4. NM_001264427.2 → NP_001251356.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU29
    Conserved Domains (3) summary
    cd03860
    Location:141 → 454
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:682 → 719
    ShK; ShK domain-like
    pfam02244
    Location:45 → 111
    Propep_M14; Carboxypeptidase activation peptide

  5. NM_001264429.3 → NP_001251358.1  ShKT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251358.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU30
    Conserved Domains (3) summary
    cd03860
    Location:141 → 454
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam01549
    Location:537 → 574
    ShK; ShK domain-like
    pfam02244
    Location:45 → 111
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein
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