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Mep1a meprin 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 17287, updated on 28-May-2016
Official Symbol
Mep1aprovided by MGI
Official Full Name
meprin 1 alphaprovided by MGI
Primary source
MGI:MGI:96963
See related
Ensembl:ENSMUSG00000023914 Vega:OTTMUSG00000029860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mep1; Mep-1; Mep-1a; AI098089; AW107200
Orthologs
Location:
17 19.73 cM; 17 C1-D1
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (43474324..43504144, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (43611278..43639722, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene ankyrin repeat domain 66 Neighboring gene RIKEN cDNA 1700071M16 gene Neighboring gene phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
meprin A complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
meprin A subunit alpha
Names
endopeptidase-2
meprin A alpha-subunit
meprin alpha
NP_032611.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008585.2NP_032611.2  meprin A subunit alpha

    See identical proteins and their annotated locations for NP_032611.2

    Status: PROVISIONAL

    Source sequence(s)
    BC015258
    Consensus CDS
    CCDS37623.1
    UniProtKB/Swiss-Prot
    P28825
    UniProtKB/TrEMBL
    A0A0R4J043
    Related
    ENSMUSP00000024707, ENSMUST00000024707
    Conserved Domains (6) summary
    cd06263
    Location:281443
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:276443
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00054
    Location:686724
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01400
    Location:86273
    Astacin; Astacin (Peptidase family M12A)
    cl02446
    Location:443607
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl00064
    Location:46271
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    43474324..43504144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523751.2XP_006523814.1  

    See identical proteins and their annotated locations for XP_006523814.1

    UniProtKB/Swiss-Prot
    P28825
    UniProtKB/TrEMBL
    A0A0R4J043
    Conserved Domains (6) summary
    cd06263
    Location:281443
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:276443
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00054
    Location:686724
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01400
    Location:86273
    Astacin; Astacin (Peptidase family M12A)
    cl02446
    Location:443607
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
    cl00064
    Location:46271
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    46896845..46925249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)