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Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]

Gene ID: 17283, updated on 24-May-2016
Official Symbol
Men1provided by MGI
Official Full Name
multiple endocrine neoplasia 1provided by MGI
Primary source
MGI:MGI:1316736
See related
Ensembl:ENSMUSG00000024947 Vega:OTTMUSG00000018611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW045611
Orthologs
Location:
19; 19 A
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (6334979..6340894)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6334979..6340894)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene EH-domain containing 1 Neighboring gene predicted gene, 32042 Neighboring gene CDC42 binding protein kinase gamma (DMPK-like) Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene uncharacterized LOC102634533 Neighboring gene splicing factor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
Y-form DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to histone-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
histone methylation IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal process involved in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast development IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoblast development ISO
Inferred from Sequence Orthology
more info
 
osteoblast fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to UV ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to transforming growth factor beta ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168488.1NP_001161960.1  menin isoform a

    See identical proteins and their annotated locations for NP_001161960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC127556, AF016398, BY619391, CF170561
    Consensus CDS
    CCDS50366.1
    UniProtKB/Swiss-Prot
    O88559
    UniProtKB/TrEMBL
    A0A0R4J1I3
    Related
    ENSMUSP00000109130, ENSMUST00000113502
    Conserved Domains (2) summary
    pfam05053
    Location:8617
    Menin; Menin
    cd14456
    Location:9464
    Menin; Scaffolding protein menin encoded by the MEN1 gene
  2. NM_001168489.1NP_001161961.1  menin isoform b

    See identical proteins and their annotated locations for NP_001161961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC127556, AF016398, BY619391
    Consensus CDS
    CCDS29502.1
    UniProtKB/Swiss-Prot
    O88559
    Related
    ENSMUSP00000078306, OTTMUSP00000020153, ENSMUST00000079327, OTTMUST00000044787
    Conserved Domains (2) summary
    pfam05053
    Location:2611
    Menin; Menin
    cd14456
    Location:3458
    Menin; Scaffolding protein menin encoded by the MEN1 gene
  3. NM_001168490.1NP_001161962.1  menin isoform c

    See identical proteins and their annotated locations for NP_001161962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AF016398, BY319905, BY619391, CX568988
    Consensus CDS
    CCDS50367.1
    UniProtKB/Swiss-Prot
    O88559
    Related
    ENSMUSP00000077272, OTTMUSP00000020155, ENSMUST00000078137, OTTMUST00000044789
    Conserved Domains (2) summary
    pfam05053
    Location:2556
    Menin; Menin
    cd14456
    Location:3390
    Menin; Scaffolding protein menin encoded by the MEN1 gene
  4. NM_008583.2NP_032609.1  menin isoform b

    See identical proteins and their annotated locations for NP_032609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AF016398, BY319905, BY619391, CX568988
    Consensus CDS
    CCDS29502.1
    UniProtKB/Swiss-Prot
    O88559
    Related
    ENSMUSP00000058149, OTTMUSP00000020154, ENSMUST00000056391, OTTMUST00000044788
    Conserved Domains (2) summary
    pfam05053
    Location:2611
    Menin; Menin
    cd14456
    Location:3458
    Menin; Scaffolding protein menin encoded by the MEN1 gene

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    6334979..6340894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    6207959..6213874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)