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NQO1 NAD(P)H dehydrogenase, quinone 1 [ Homo sapiens (human) ]

Gene ID: 1728, updated on 17-Apr-2014
Official Symbol
NQO1provided by HGNC
Official Full Name
NAD(P)H dehydrogenase, quinone 1provided by HGNC
Primary source
HGNC:2874
See related
Ensembl:ENSG00000181019; HPRD:00518; MIM:125860; Vega:OTTHUMG00000137575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; QR1; DHQU; DIA4; NMOR1; NMORI
Summary
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Location :
16q22.1
Sequence :
Chromosome: 16; NC_000016.10 (69709401..69726668, complement)
See NQO1 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene microRNA 1538 Neighboring gene nuclear factor of activated T-cells 5, tonicity-responsive Neighboring gene NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) Neighboring gene non-POU domain containing, octamer-binding pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly upregulates Nrf2 in human astrocytes and is associated with increased levels of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1) PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)H dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
 
cytochrome-b5 reductase activity, acting on NAD(P)H TAS
Traceable Author Statement
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, cholinergic TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
NAD(P)H dehydrogenase [quinone] 1
Names
NAD(P)H dehydrogenase [quinone] 1
azoreductase
diaphorase-4
DT-diaphorase
dioxin-inducible 1
menadione reductase
quinone reductase 1
phylloquinone reductase
NAD(P)H:quinone oxireductase
NAD(P)H:quinone oxidoreductase 1
NAD(P)H:menadione oxidoreductase 1
NAD(P)H:Quinone acceptor oxidoreductase type 1
diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
NP_000894.1
NP_001020604.1
NP_001020605.1
NP_001273066.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011504.1 RefSeqGene

    Range
    4963..22230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000903.2NP_000894.1  NAD(P)H dehydrogenase [quinone] 1 isoform a

    See proteins identical to NP_000894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AV729122, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS10883.1
    UniProtKB/Swiss-Prot
    P15559
    Related
    ENSP00000319788, OTTHUMP00000174897, ENST00000320623, OTTHUMT00000268956
    Conserved Domains (1) summary
    pfam02525
    Location:5212
    Blast Score: 393
    Flavodoxin_2; Flavodoxin-like fold
  2. NM_001025433.1NP_001020604.1  NAD(P)H dehydrogenase [quinone] 1 isoform b

    See proteins identical to NP_001020604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AV729122, BC000906, BC007659, BM052991, BM452267, BM787983, BM828301
    Consensus CDS
    CCDS32472.1
    UniProtKB/Swiss-Prot
    P15559
    Related
    ENSP00000368335, OTTHUMP00000174898, ENST00000379047, OTTHUMT00000268957
    Conserved Domains (1) summary
    pfam02525
    Location:5178
    Blast Score: 279
    Flavodoxin_2; Flavodoxin-like fold
  3. NM_001025434.1NP_001020605.1  NAD(P)H dehydrogenase [quinone] 1 isoform c

    See proteins identical to NP_001020605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AV729122, BM052991, BM452267, BM787983, BM828301, CD014005
    Consensus CDS
    CCDS32471.1
    UniProtKB/Swiss-Prot
    P15559
    Conserved Domains (1) summary
    pfam02525
    Location:5174
    Blast Score: 219
    Flavodoxin_2; Flavodoxin-like fold
  4. NM_001286137.1NP_001273066.1  NAD(P)H dehydrogenase [quinone] 1 isoform d

    See proteins identical to NP_001273066.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform d) is shorter than isoform a.
    Source sequence(s)
    AC092115, AK297125, BQ775231, DC331440
    Consensus CDS
    CCDS67067.1
    UniProtKB/TrEMBL
    B4DLR8
    Conserved Domains (1) summary
    cl00438
    Location:4101
    Blast Score: 130
    FMN_red; NADPH-dependent FMN reductase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38 Primary Assembly

    Range
    69709401..69726668, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 Alternate HuRef

    Range
    55621397..55638644, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    71151192..71168455, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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