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    Melk maternal embryonic leucine zipper kinase [ Mus musculus (house mouse) ]

    Gene ID: 17279, updated on 5-May-2013
    Official Symbol
    Melkprovided by MGI
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by MGI
    Primary source
    MGI:106924
    Locus tag
    RP23-382O11.1
    See related
    Ensembl:ENSMUSG00000035683; Vega:OTTMUSG00000006665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPK38; AI327312; mKIAA0175
    Location :
    4 B1; 4 23.46 cM
    Sequence :
    Chromosome: 4; NC_000070.6 (44300917..44364675)
    See Melk in Epigenomics, MapViewer

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 38 Neighboring gene microRNA 5106 Neighboring gene predicted gene, 19980 Neighboring gene paired box gene 5 Neighboring gene microRNA 5120

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity. Seong HA, et al. J Biol Chem, 2012 Jun 15. PMID 22544756.
    2. Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation. Seong HA, et al. J Biol Chem, 2012 Jun 15. PMID 22532570.
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    5. Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo. Hebbard LW, et al. Cancer Res, 2010 Nov 1. PMID 20861186.

    See all (31) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. an important role for MPK38-mediated phosphorylation of PDK1 in the negative regulation of PDK1 activity.
      Title: PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.
    2. MPK38 may act as a novel regulator for promoting p53 activity through direct phosphorylation of p53 at Ser(15).
      Title: Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation.
    3. Upregulation of maternal embryonic leucine zipper kinase is associated with mammary tumor.
      Title: Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.
    4. MPK38 physically interacts with ASK1 in vivo and acts as a positive upstream regulator of ASK1
      Title: Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.
    5. The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported.
      Title: Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3.
    6. MELK is necessary for proliferation of embryonic and postnatal MNP and suggest that it regulates the transition from GFAP-expressing progenitors to rapid amplifying progenitors in the postnatal brain.
      Title: Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:201390 BioGRID:124717 ZNF622    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    neural precursor cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    maternal embryonic leucine zipper kinase
    protein kinase PK38
    tyrosine-protein kinase MELK
    NP_034920.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010790.2 → NP_034920.2  maternal embryonic leucine zipper kinase

      Status: PROVISIONAL

      Source sequence(s)
      AK011932
      Consensus CDS
      CCDS18124.1
      UniProtKB/Swiss-Prot
      Q61846
      Related
      ENSMUSP00000043806, OTTMUSP00000007045, ENSMUST00000045607, OTTMUST00000015242
      Conserved Domains (3) summary
      cd05123
      Location:17 – 262
      Blast Score: 618
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      pfam02149
      Location:598 – 642
      Blast Score: 158
      KA1; Kinase associated domain 1
      smart00220
      Location:16 – 263
      Blast Score: 825
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p1 C57BL/6J

      Range
      44300917..44364675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      44320472..44384714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01035376.1 (13993..15135) None
    genomic AAHY01035377.1 None
    genomic AAHY01035378.1 None
    genomic AAHY01035379.1 None
    genomic AAHY01035380.1 (4367..40146) None
    genomic AL805952.11 (159327..199539) None
    genomic AL807399.5 (2000..25545) None
    genomic CH466565.2 EDL02425.1 mixed
      EDL02426.1 mixed
    mRNA AK010498.1 None C57BL/6J
    mRNA AK011932.1 BAB27923.1 C57BL/6J
    mRNA AK129076.1 BAC97886.1
    mRNA AK137000.1 None C57BL/6J
    mRNA AK145021.1 BAE26188.1
    mRNA AK145316.1 BAE26362.1 C57BL/6J
    mRNA AK161029.1 BAE36156.1 C57BL/6J
    mRNA AK164138.1 BAE37644.1 C57BL/6J
    mRNA AK167457.1 BAE39542.1 C57BL/6J
    mRNA AK206998.1 None
    mRNA AK208560.1 None
    mRNA BC020416.1 None CZECHII
    mRNA BC055065.1 None C3H/He
    mRNA BC085276.1 AAH85276.1 C57BL/6J
    mRNA L76158.1 AAB72030.1
    mRNA X95351.1 CAA64641.1 B6D2F1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61846.2 GenPept UniProtKB/Swiss-Prot:Q61846

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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