Mdm4 transformed mouse 3T3 cell double minute 4 [Mus musculus] - Gene

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Summary

Official Symbol: Mdm4provided by MGI
Official Full Name: transformed mouse 3T3 cell double minute 4provided by MGI
Primary source: MGI:107934
See related: Ensembl:ENSMUSG00000054387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mdmx; C85810; AA414968; AL023055; AU018793; AU021806; 4933417N07Rik

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Genomic context

Location :: 1 G-G; 1 70.0 cM

Sequence :: Chromosome: 1; NC_000067.6 (132989845..133025348, complement)

See Mdm4 in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that systemic inhibition of MdmX is both a feasible therapeutic strategy for restoring p53 function in tumors that retain wild-type p53 and likely to be significantly safer than inhibition of Mdm2.
Title: Validation of MdmX as a therapeutic target for reactivating p53 in tumors.
MDM2 and MDMX function as an integral complex in p53 control.
Title: The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Title: Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.
Title: MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.
a new role for 14-3-3gamma in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53.
Title: 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.
Title: Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.
Data show that although both Mdm2 and Mdm4 transgenes are designed to be expressed ubiquitously and at comparable levels, only the Mdm4 transgenic protein is produced at high levels in vivo.
Title: Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo.
overall negative control of MDM4 by p76(MDM2) reflects on p53 function as p76(MDM2) impairs MDM4-mediated inhibition of p53 activity
Title: Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.
Mdm4 is thus a bona fide oncogene in vivo and cooperates with p53 heterozygosity to drive tumorigenesis.
Title: Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4.
Murine mdmx gene also contains a functional p53-responsive P2 promoter in intron 1, and mdmx-P2 transcripts are clearly induced in response to diverse p53-activating signals.
Title: HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

Submit: New GeneRIF Correction See all (35)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (2) 1 citation
Targeted (knock-out) (2) 1 citation
Gene trapped (1) 1 citation
Targeted (knock-in) (3) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:201373	BioGRID:198651	Cdkn1a	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201373	BioGRID:110358	MDM2	BioGRID	PubMed	Biochemical Activity
BioGRID:201373	BioGRID:201372	Mdm2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201373	BioGRID:113010	TP53	BioGRID	PubMed	Biochemical Activity
BioGRID:201373	BioGRID:204323	Trp53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201373	BioGRID:204403	Ubc	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201373	BioGRID:232963	Usp7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201373	BioGRID:204620	Ywhag	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
enzyme binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle arrest	IEA Inferred from Electronic Annotation more info
negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
protein complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein Mdm4

Names: protein Mdm4; protein Mdmx; double minute 4 protein; p53-binding protein Mdm4; mdm2-like p53-binding protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008575.3 → NP_032601.2 protein Mdm4

Status: PROVISIONAL

Source sequence(s)

AK083349

Consensus CDS

CCDS15290.1

UniProtKB/Swiss-Prot

O35618

Related

ENSMUSP00000070411, ENSMUST00000067429

Conserved Domains (3) summary

cl02489
Location:26 – 101
Blast Score: 153

SWIB; SWIB/MDM2 domain

cl02656
Location:300 – 328
Blast Score: 103

zf-RanBP; Zn-finger in Ran binding protein and others

cl15348
Location:436 – 481
Blast Score: 82

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

132989845..133025348, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

135598842..135634680, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC137948.12 (45103..80606)	None
genomic	AF353726.1	None	129/SvEvTac
genomic	CH466520.2	EDL39660.1	mixed
		EDL39661.1	mixed
		EDL39662.1	mixed
		EDL39663.1	mixed
		EDL39664.1	mixed
		EDL39665.1	mixed
mRNA	AF007110.1	AAB62927.1
mRNA	AK016849.1	None	C57BL/6J
mRNA	AK017719.1	BAB30893.1	C57BL/6J
mRNA	AK028493.1	None	C57BL/6J
mRNA	AK043359.1	None	C57BL/6J
mRNA	AK046448.1	None	C57BL/6J
mRNA	AK049576.1	None	C57BL/6J
mRNA	AK049690.1	None	C57BL/6J
mRNA	AK083349.1	BAC38879.1	C57BL/6J
mRNA	AK139529.1	BAE24051.1	C57BL/6J
mRNA	AK139535.1	None	C57BL/6J
mRNA	AK161882.1	None	C57BL/6J
mRNA	AK184147.1	None
mRNA	BC003750.1	AAH03750.1	FVB/N
mRNA	BC023912.1	None	FVB/N
mRNA	BC025868.1	None
mRNA	EU568360.1	ACB69756.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O35618.2	GenPept	UniProtKB/Swiss-Prot:O35618
Q3UTC9	GenPept	UniProtKB/TrEMBL:Q3UTC9
Q99L86	GenPept	UniProtKB/TrEMBL:Q99L86