Format

Send to:

Choose Destination

Mdk midkine [ Mus musculus (house mouse) ]

Gene ID: 17242, updated on 8-May-2016
Official Symbol
Mdkprovided by MGI
Official Full Name
midkineprovided by MGI
Primary source
MGI:MGI:96949
See related
Ensembl:ENSMUSG00000027239 Vega:OTTMUSG00000014364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MK; Mek
Summary
This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
Location:
2 E1; 2 50.63 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (91929805..91932297, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91769978..91772439, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene predicted gene, 39876 Neighboring gene microRNA 6999 Neighboring gene diacylglycerol kinase zeta Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene predicted gene, 31473

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cerebellar granular layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
midkine
Names
retinoic acid-induced differentiation factor
retinoic acid-responsive protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012335.2NP_001012335.1  midkine isoform a precursor

    See identical proteins and their annotated locations for NP_001012335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    AL731772, CF728526, CF738400
    Consensus CDS
    CCDS16440.1
    UniProtKB/Swiss-Prot
    P12025
    Related
    ENSMUSP00000088090, OTTMUSP00000015222, ENSMUST00000090602, OTTMUST00000033985
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family
  2. NM_001012336.2NP_001012336.1  midkine isoform a precursor

    See identical proteins and their annotated locations for NP_001012336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as MK2; PMID 2345177) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    AL731772, BY092625, CF728526, M34327
    Consensus CDS
    CCDS16440.1
    UniProtKB/Swiss-Prot
    P12025
    Related
    ENSMUSP00000068413, OTTMUSP00000015221, ENSMUST00000069423, OTTMUST00000033984
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family
  3. NM_001291481.1NP_001278410.1  midkine isoform a precursor

    See identical proteins and their annotated locations for NP_001278410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same isoform (a).
    Source sequence(s)
    CF728526, CJ174056
    Consensus CDS
    CCDS16440.1
    UniProtKB/Swiss-Prot
    P12025
    Related
    ENSMUSP00000106941, OTTMUSP00000015223, ENSMUST00000111309, OTTMUST00000033986
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family
  4. NM_001291482.1NP_001278411.1  midkine isoform b

    See identical proteins and their annotated locations for NP_001278411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL731772, BY092625, CF728526, CJ174578
    Conserved Domains (1) summary
    cl02505
    Location:163
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
  5. NM_001291483.1NP_001278412.1  midkine isoform c precursor

    See identical proteins and their annotated locations for NP_001278412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform 1.
    Source sequence(s)
    AL731772
    UniProtKB/TrEMBL
    Q2LEK5
    Conserved Domains (1) summary
    cl02505
    Location:3479
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain
  6. NM_010784.5NP_034914.1  midkine isoform a precursor

    See identical proteins and their annotated locations for NP_034914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as MK3; PMID 2345177) represents the longest transcript and encodes the longest isoform (a). Variants 1 through 4 encode the same isoform.
    Source sequence(s)
    AL731772, CF728526, M34328
    Consensus CDS
    CCDS16440.1
    UniProtKB/Swiss-Prot
    P12025
    Related
    ENSMUSP00000028672, OTTMUSP00000015220, ENSMUST00000028672, OTTMUST00000033983
    Conserved Domains (1) summary
    smart00193
    Location:34113
    PTN; Pleiotrophin / midkine family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    91929805..91932297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239335.1XP_011237637.1  

    See identical proteins and their annotated locations for XP_011237637.1

    Conserved Domains (1) summary
    cl02505
    Location:163
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    93320207..93322695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)