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Mcl1 myeloid cell leukemia sequence 1 [ Mus musculus (house mouse) ]

Gene ID: 17210, updated on 13-Sep-2014
Official Symbol
Mcl1provided by MGI
Official Full Name
myeloid cell leukemia sequence 1provided by MGI
Primary source
MGI:101769
See related
Ensembl:ENSMUSG00000038612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcl-1; AW556805
See Mcl1 in Epigenomics, MapViewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (95658347..95663179)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 1 Neighboring gene endosulfine alpha Neighboring gene uncharacterized LOC102631590 Neighboring gene ADAMTS-like 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-7 Signaling Pathway, organism-specific biosystem
    IL-7 Signaling Pathway
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
BH domain binding ISO
Inferred from Sequence Orthology
more info
 
BH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
response to cytokine ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Names
induced myeloid leukemia cell differentiation protein Mcl-1 homolog
bcl-2-related protein EAT/mcl1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008562.3NP_032588.1  induced myeloid leukemia cell differentiation protein Mcl-1 homolog

    See proteins identical to NP_032588.1

    Status: VALIDATED

    Source sequence(s)
    AA174356, AC092479, AK159504, CJ183408
    Consensus CDS
    CCDS57236.1
    UniProtKB/Swiss-Prot
    P97287
    Related
    ENSMUSP00000044048, ENSMUST00000037947
    Conserved Domains (1) summary
    cd06845
    Location:156299
    Blast Score: 367
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    95658347..95663179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501088.1XP_006501151.1  

    Conserved Domains (1) summary
    cd06845
    Location:156211
    Blast Score: 95
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    97090304..97094626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)