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aars-2 Alanine--tRNA ligase, cytoplasmic [ Caenorhabditis elegans ]

Gene ID: 171985, updated on 23-Nov-2023

Summary

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Gene symbol
aars-2
Gene description
Alanine--tRNA ligase, cytoplasmic
Primary source
WormBase:WBGene00000197
Locus tag
CELE_F28H1.3
See related
AllianceGenome:WB:WBGene00000197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable several functions, including ATP binding activity; catalytic activity, acting on a tRNA; and tRNA binding activity. Predicted to be involved in alanyl-tRNA aminoacylation and tRNA modification. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed widely. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; combined oxidative phosphorylation deficiency 8; and developmental and epileptic encephalopathy 29. Orthologous to several human genes including AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (3983183..3986581)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential genes in the hDf6 region of chromosome I in Caenorhabditis elegans. Howell AM, et al. Genetics, 1990 Nov. PMID 2249758, Free PMC Article
  2. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
  3. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
  4. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables alanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Alanine--tRNA ligase, cytoplasmic
NP_491281.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3983183..3986581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058880.7 → NP_491281.1  Alanine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491281.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01541, Q17371
    Conserved Domains (4) summary
    PLN02900
    Location:5 → 965
    PLN02900; alanyl-tRNA synthetase
    cd00673
    Location:6 → 254
    AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    pfam02272
    Location:892 → 961
    DHHA1; DHHA1 domain
    cl08469
    Location:530 → 754
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01541.1

Gene LinkOut

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