Display Settings:

Format

Send to:

Choose Destination

Mbp myelin basic protein [ Mus musculus (house mouse) ]

Gene ID: 17196, updated on 24-Dec-2014
Official Symbol
Mbpprovided by MGI
Official Full Name
myelin basic proteinprovided by MGI
Primary source
MGI:MGI:96925
See related
Ensembl:ENSMUSG00000041607; Vega:OTTMUSG00000016316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mld; shi; Hmbpr; C76307; R75289; golli-mbp
Summary
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Location:
18 E2-E4; 18 55.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 18 NC_000084.6 (82475123..82585637)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene galanin receptor 1 Neighboring gene predicted gene, 30642 Neighboring gene ribosomal protein L21, pseudogene 8 Neighboring gene zinc finger protein 236 Neighboring gene microRNA 5112

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MAPK Cascade, organism-specific biosystem (from WikiPathways)
    MAPK Cascade, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
membrane organization IDA
Inferred from Direct Assay
more info
PubMed 
myelination IDA
Inferred from Direct Assay
more info
PubMed 
response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
internode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
Golli-Mbp; myelin basic protein
Names
myelin basic protein
shiverer
myelin deficient
myelin A1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025245.1NP_001020416.1  Golli-Mbp isoform 2

    See proteins identical to NP_001020416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).
    Source sequence(s)
    AC117825, AK039047, AK040716
    Consensus CDS
    CCDS29374.1
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q5D096
    Related
    ENSMUSP00000089393, OTTMUSP00000017515, ENSMUST00000091789, OTTMUST00000039210
    Conserved Domains (1) summary
    pfam01669
    Location:147193
    Myelin_MBP; Myelin basic protein
  2. NM_001025251.2NP_001020422.1  myelin basic protein isoform 1

    See proteins identical to NP_001020422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
    Source sequence(s)
    AC119259, BF457157, BY245551, CO425201
    Consensus CDS
    CCDS29376.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000053495, ENSMUST00000062446
    Conserved Domains (1) summary
    pfam01669
    Location:14150
    Myelin_MBP; Myelin basic protein
  3. NM_001025254.2NP_001020425.1  myelin basic protein isoform 2

    See proteins identical to NP_001020425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.
    Source sequence(s)
    BB633793, BC004704
    Consensus CDS
    CCDS37875.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000110322, ENSMUST00000114674
    Conserved Domains (1) summary
    pfam01669
    Location:14183
    Myelin_MBP; Myelin basic protein
  4. NM_001025255.2NP_001020426.1  myelin basic protein isoform 3

    See proteins identical to NP_001020426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, CK623660
    Consensus CDS
    CCDS29377.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000099876, ENSMUST00000102812
    Conserved Domains (1) summary
    pfam01669
    Location:14124
    Myelin_MBP; Myelin basic protein
  5. NM_001025256.2NP_001020427.1  myelin basic protein isoform 4

    See proteins identical to NP_001020427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK079621, BY245551
    Consensus CDS
    CCDS29378.1
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q542T4
    Related
    ENSMUSP00000079488, ENSMUST00000080658
    Conserved Domains (1) summary
    pfam01669
    Location:14139
    Myelin_MBP; Myelin basic protein
  6. NM_001025258.2NP_001020429.1  myelin basic protein isoform 5

    See proteins identical to NP_001020429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, BY245551, M15062
    Consensus CDS
    CCDS29379.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000074836, ENSMUST00000075372
    Conserved Domains (1) summary
    pfam01669
    Location:14157
    Myelin_MBP; Myelin basic protein
  7. NM_001025259.2NP_001020430.1  myelin basic protein isoform 6

    See proteins identical to NP_001020430.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AC119259, AK005129, BY245551
    UniProtKB/Swiss-Prot
    P04370
    UniProtKB/TrEMBL
    Q3UGF3
    Related
    ENSMUSP00000116019, OTTMUSP00000022344, ENSMUST00000133193, OTTMUST00000048639
    Conserved Domains (1) summary
    pfam01669
    Location:14113
    Myelin_MBP; Myelin basic protein
  8. NM_010777.3NP_034907.1  Golli-Mbp isoform 1

    See proteins identical to NP_034907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).
    Source sequence(s)
    AC117825, AC119259, L07507
    Consensus CDS
    CCDS29373.1
    UniProtKB/Swiss-Prot
    P04370
    Related
    ENSMUSP00000046185, OTTMUSP00000017514, ENSMUST00000047865, OTTMUST00000039208
    Conserved Domains (1) summary
    pfam01669
    Location:147245
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000084.6 

    Range
    82475123..82585637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526452.1XP_006526515.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147256
    Myelin_MBP; Myelin basic protein
  2. XM_006526455.1XP_006526518.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147256
    Myelin_MBP; Myelin basic protein
  3. XM_006526453.1XP_006526516.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147283
    Myelin_MBP; Myelin basic protein
  4. XM_006526457.1XP_006526520.1  

    See proteins identical to XP_006526520.1

    Conserved Domains (1) summary
    pfam01669
    Location:147272
    Myelin_MBP; Myelin basic protein
  5. XM_006526454.1XP_006526517.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147230
    Myelin_MBP; Myelin basic protein
  6. XM_006526456.1XP_006526519.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147257
    Myelin_MBP; Myelin basic protein
  7. XM_006526458.1XP_006526521.1  

    Conserved Domains (1) summary
    pfam01669
    Location:147246
    Myelin_MBP; Myelin basic protein

Alternate Mm_Celera

Genomic

  1. AC_000040.1 

    Range
    83548320..83655575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)