U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tpxl-1 TPX2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171786, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
tpxl-1
Gene description
TPX2 domain-containing protein
Primary source
WormBase:WBGene00021470
Locus tag
CELE_Y39G10AR.12
See related
AllianceGenome:WB:WBGene00021470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in astral microtubule organization and mitotic spindle assembly. Located in astral microtubule; meiotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (2297392..2304397, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cyclin-dependent kinase 7 Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene Ectopic P granules protein 2 Neighboring gene Inner centromere protein ARK-binding domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo. Lewellyn L, et al. Mol Biol Cell, 2010 Jan 1. PMID 19889842, Free PMC Article
  2. TPX or not TPX? Karsenti E. Mol Cell, 2005 Aug 19. PMID 16109366
  3. An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos. Hara Y, et al. Mol Biol Cell, 2013 May. PMID 23468523, Free PMC Article
  4. The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans. Han X, et al. PLoS One, 2015. PMID 26168236, Free PMC Article
  5. A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos. Toya M, et al. Nat Cell Biol, 2011 Jun. PMID 21572421

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. polar clearing is an active process that requires activation of Aurora A kinase by TPXL-1. TPXL-1 concentrates on astral microtubules coincident with polar clearing in anaphase, and its ability to recruit Aurora A and activate its kinase activity are essential for clearing.
    Title: TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.
  2. Centrosome size sets mitotic spindle length by controlling the length scale of a TPXL-1 gradient along spindle microtubules.
    Title: Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos.
  3. Activation and targeting of Aurora A appears to be an ancient and conserved function of TPX2 that plays a central role in mitotic spindle assembly.
    Title: An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
TPX2 domain-containing protein
NP_740805.1
  • Confirmed by transcript evidence
NP_740806.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2297392..2304397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170821.7 → NP_740805.1  TPX2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDE7
    Conserved Domains (1) summary
    PHA03247
    Location:132 → 455
    PHA03247; large tegument protein UL36; Provisional

  2. NM_170822.8 → NP_740806.1  TPX2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WSN6
    Conserved Domains (1) summary
    PHA03247
    Location:102 → 455
    PHA03247; large tegument protein UL36; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous