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Mapkapk5 MAP kinase-activated protein kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 17165, updated on 22-May-2016
Official Symbol
Mapkapk5provided by MGI
Official Full Name
MAP kinase-activated protein kinase 5provided by MGI
Primary source
MGI:MGI:1333110
See related
Ensembl:ENSMUSG00000029454 Ensembl:ENSMUSG00000105340 Vega:OTTMUSG00000023483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MK5; PRAK
Orthologs
Location:
5; 5 F
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (121525051..121545892, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (121975060..121995901, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene aldehyde dehydrogenase 2, mitochondrial Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: Adam1a

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of translation ISO
Inferred from Sequence Orthology
more info
 
stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
septin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
MAP kinase-activated protein kinase 5
Names
MAPK-activated protein kinase 5
MAPKAP kinase 5
MAPKAPK-5
NP_034895.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010765.2NP_034895.1  MAP kinase-activated protein kinase 5

    See identical proteins and their annotated locations for NP_034895.1

    Status: VALIDATED

    Source sequence(s)
    AF039840, BY722898
    Consensus CDS
    CCDS39248.1
    UniProtKB/Swiss-Prot
    O54992
    Related
    ENSMUSP00000031410, OTTMUSP00000027532, ENSMUST00000031410, OTTMUST00000057139
    Conserved Domains (2) summary
    smart00220
    Location:26304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14171
    Location:15304
    STKc_MAPKAPK5; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    121525051..121545892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    118614887..118635774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)