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Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 171580, updated on 8-May-2016
Official Symbol
Mical1provided by MGI
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 1provided by MGI
Primary source
MGI:MGI:2385847
See related
Ensembl:ENSMUSG00000019823 Vega:OTTMUSG00000030589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MICAL; Nical; MICAL-1
Orthologs
Location:
10; 10 B1-B2
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (41475860..41487030)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (41196120..41206836)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene adenylate kinase 9 Neighboring gene ClpB caseinolytic peptidase B homolog pseudogene Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene sphingomyelin phosphodiesterase 2, neutral Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 6

Homology

Clone Names

  • MGC27831, MGC38321

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-hydroxy-2-naphthoate hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
1-hydroxy-2-oxolimonene 1,2-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
1-methylnaphthalene hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
2-hydroxy-phenylacetate hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
2-methylnaphthalene hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
3,5-xylenol methylhydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
3-(3-hydroxyphenyl)propionate hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
3-HSA hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
4-chlorobenzaldehyde oxidase activity IEA
Inferred from Electronic Annotation
more info
 
4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity IEA
Inferred from Electronic Annotation
more info
 
4-hydroxypyridine-3-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
4-nitrophenol 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
6-hydroxynicotinate 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
FAD binding ISO
Inferred from Sequence Orthology
more info
 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding ISO
Inferred from Sequence Orthology
more info
 
alpha-pinene monooxygenase [NADH] activity IEA
Inferred from Electronic Annotation
more info
 
bisphenol A hydroxylase A activity IEA
Inferred from Electronic Annotation
more info
 
branched-chain dodecylbenzene sulfonate monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
carbon disulfide oxygenase activity IEA
Inferred from Electronic Annotation
more info
 
chlorophenol 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
dibenzothiophene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
dimethyl sulfide monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
isobutylamine N-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
limonene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
 
phenanthrene 1,2-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene 3,4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
phenanthrene 9,10-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
phenylacetate hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
salicylate 5-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
styrene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
tetrahydrofuran hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
thalianol hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
tocotrienol omega-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
toluene 2-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
toluene 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
toluene 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
toluene-4-sulfonate monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
toluene-sulfonate methyl-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
xylene monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
sulfur oxidation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein-methionine sulfoxide oxidase MICAL1
Names
CasL interacting molecule MICAL
NEDD9 interacting protein with calponin homology and LIM domains
NEDD9-interacting protein with calponin homology and LIM domains
mMical1
microtubule associated monoxygenase, calponin and LIM domain containing 1
molecule interacting with CasL protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164433.1NP_001157905.1  protein-methionine sulfoxide oxidase MICAL1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC153360, AK159369, AK171411, AK171429
    Consensus CDS
    CCDS48547.1
    UniProtKB/Swiss-Prot
    Q8VDP3
    Related
    ENSMUSP00000097519, OTTMUSP00000039778, ENSMUST00000099934, OTTMUST00000075756
    Conserved Domains (3) summary
    cd09358
    Location:610663
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:438537
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:839972
    DUF3585; Protein of unknown function (DUF3585)
  2. NM_138315.2NP_612188.1  protein-methionine sulfoxide oxidase MICAL1 isoform 1

    See identical proteins and their annotated locations for NP_612188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153360, AK171411, AK171429
    Consensus CDS
    CCDS35888.1
    UniProtKB/Swiss-Prot
    Q8VDP3
    Related
    ENSMUSP00000019967, ENSMUST00000019967
    Conserved Domains (4) summary
    cd09358
    Location:683736
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:511610
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:9121045
    DUF3585; Protein of unknown function (DUF3585)
    cl21454
    Location:89119
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    41475860..41487030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512570.1XP_006512633.1  

    Conserved Domains (4) summary
    cd09358
    Location:842895
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:670769
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:10711204
    DUF3585; Protein of unknown function (DUF3585)
    cl21454
    Location:248278
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_006512574.1XP_006512637.1  

    Conserved Domains (4) summary
    cd09358
    Location:452505
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:280379
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:681814
    DUF3585; Protein of unknown function (DUF3585)
    pfam15356
    Location:505588
    SPR1; Psoriasis susceptibility locus 2
  3. XM_011243137.1XP_011241439.1  

    See identical proteins and their annotated locations for XP_011241439.1

    UniProtKB/Swiss-Prot
    Q8VDP3
    Conserved Domains (4) summary
    cd09358
    Location:683736
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:511610
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:9121045
    DUF3585; Protein of unknown function (DUF3585)
    cl21454
    Location:89119
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_011243138.1XP_011241440.1  

    See identical proteins and their annotated locations for XP_011241440.1

    Conserved Domains (3) summary
    cd09358
    Location:498551
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:326425
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:727860
    DUF3585; Protein of unknown function (DUF3585)
  5. XM_006512573.1XP_006512636.1  

    See identical proteins and their annotated locations for XP_006512636.1

    Conserved Domains (3) summary
    cd09358
    Location:498551
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    cd00014
    Location:326425
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam12130
    Location:727860
    DUF3585; Protein of unknown function (DUF3585)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    42362567..42373283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)