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    POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) [ Homo sapiens ]

    Gene ID: 171568, updated on 12-May-2012

    Summary

    Official Symbol
    POLR3Hprovided by HGNC
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)provided by HGNC
    Primary source
    HGNC:30349
    Locus tag
    RP3-347H13.9
    See related
    Ensembl:ENSG00000100413; HPRD:15157; Vega:OTTHUMG00000150971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPC8; RPC22.9; KIAA1665; MGC29654; MGC111097

    Genomic context

    Location :
    22q13.2
    Sequence :
    Chromosome: 22; NC_000022.10 (41921803..41940479, complement)
    See POLR3H in Epigenomics, MapViewer

    Chromosome 22 - NC_000022.10Genomic Context describing neighboring genes Neighboring gene transducer of ERBB2, 2 Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2, mitochondrial Neighboring gene cold shock domain containing C2, RNA binding Neighboring gene phosphomannomutase 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y535 O75575 CRCP    HPRD  PubMed  
    BioGRID:128147 BioGRID:117115 CDC42EP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:111127 PCBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:119272 POLR1D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:111433 POLR2H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:116301 POLR3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:120828 POLR3B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:115868 POLR3C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:107129 POLR3D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:120840 POLR3E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:115867 POLR3G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128147 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the POLR3H gene: The POLR3H gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , and S.pombe.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    termination of RNA polymerase III transcription TAS
    Traceable Author Statement
    more info
     
    transcription elongation from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
     
    transcription from RNA polymerase III promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    DNA-directed RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC8
    Names
    DNA-directed RNA polymerase III subunit RPC8
    RNA polymerase III subunit C8
    RNA polymerase III subunit RPC8
    DNA-directed RNA polymerase III subunit H
    RNA nucleotidyltransferase (DNA-directed)
    RNA polymerase III subunit 22.9 kDa subunit
    DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide
    NP_001018060.1
    NP_001018062.1
    NP_612211.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018050.2NP_001018060.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      Status: VALIDATED

      Source sequence(s)
      AB051452, AK000365, AK026524, AL023553, BM681267, DA238361
      Consensus CDS
      CCDS14018.1
      UniProtKB/Swiss-Prot
      Q9Y535
      Related
      ENSP00000347345, OTTHUMP00000198835, ENST00000355209, OTTHUMT00000320701
      Conserved Domains (3) summary
      COG1095
      Location:1202
      Blast Score: 339
      RPB7; DNA-directed RNA polymerase, subunit E' [Transcription]
      cd04330
      Location:281
      Blast Score: 353
      RNAP_III_Rpc25_N; RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, ...
      pfam08292
      Location:79201
      Blast Score: 466
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    2. NM_001018052.2NP_001018062.1  DNA-directed RNA polymerase III subunit RPC8 isoform b

      Status: VALIDATED

      Source sequence(s)
      AB051452, AK000365, AK026524, AL023553, BM681267, DA238361
      Consensus CDS
      CCDS33651.1
      UniProtKB/Swiss-Prot
      Q9Y535
      Related
      ENSP00000337627, OTTHUMP00000198839, ENST00000337566, OTTHUMT00000320707
      Conserved Domains (3) summary
      COG1095
      Location:1173
      Blast Score: 235
      RPB7; DNA-directed RNA polymerase, subunit E' [Transcription]
      cd04330
      Location:272
      Blast Score: 304
      RNAP_III_Rpc25_N; RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, ...
      pfam08292
      Location:69172
      Blast Score: 379
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25
    3. NM_138338.3NP_612211.1  DNA-directed RNA polymerase III subunit RPC8 isoform a

      Status: VALIDATED

      Source sequence(s)
      AB051452, AK000365, AK026524, AK129663, AY092087
      Consensus CDS
      CCDS14018.1
      UniProtKB/TrEMBL
      Q6ZPA8
      UniProtKB/Swiss-Prot
      Q9Y535
      Related
      ENSP00000379761, ENST00000396504
      Conserved Domains (3) summary
      COG1095
      Location:1202
      Blast Score: 339
      RPB7; DNA-directed RNA polymerase, subunit E' [Transcription]
      cd04330
      Location:281
      Blast Score: 353
      RNAP_III_Rpc25_N; RNAP_III_Rpc25_N: Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, ...
      pfam08292
      Location:79201
      Blast Score: 466
      RNA_pol_Rbc25; RNA polymerase III subunit Rpc25

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000022.10 Reference GRCh37.p5 Primary Assembly

      Range
      41921803..41940479, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000154.1 Alternate HuRef

      Range
      24887617..24906295, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001018051.1: Suppressed sequence

      Description
      NM_001018051.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL023553.5 CAB46023.1
      CAQ10207.1
    genomic AL023553.5 CAB46023.1
      CAQ10207.1
    genomic CH471095.1 EAW60437.1
      EAW60438.1
      EAW60439.1
      EAW60440.1
      EAW60441.1
    mRNA AB051452.1 BAB33335.1
    mRNA AK000365.1 None
    mRNA AK026524.1 None
    mRNA AK129663.1 BAC85211.1
    mRNA AY092087.1 AAM18217.1
    mRNA BC017248.2 AAH17248.1
    mRNA BC088367.1 AAH88367.1
    mRNA BI754673.1 None
    mRNA BM681267.1 None
    mRNA BU928882.1 None
    mRNA BX331353.2 None
    mRNA BX367405.2 None
    mRNA CB126821.1 None
    mRNA CR456459.1 CAG30345.1
    mRNA DA238361.1 None
    other-genetic CU013009.1 CAK54440.1
    other-genetic CU013297.1 CAK54739.1
    other-genetic GQ129271.1 ACT64405.1
    other-genetic GQ129272.1 ACT64406.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPA8 GenPept UniProtKB/TrEMBL:Q6ZPA8
    Q9Y535.1 GenPept UniProtKB/Swiss-Prot:Q9Y535

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