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PTCRA pre T-cell antigen receptor alpha [ Homo sapiens (human) ]

Gene ID: 171558, updated on 19-Nov-2014
Official Symbol
PTCRAprovided by HGNC
Official Full Name
pre T-cell antigen receptor alphaprovided by HGNC
Primary source
HGNC:HGNC:21290
Locus tag
RP3-475N16.3
See related
Ensembl:ENSG00000171611; HPRD:08435; MIM:606817; Vega:OTTHUMG00000014709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTA; PT-ALPHA
Summary
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
See PTCRA in Epigenomics, MapViewer
Location:
6p21.3
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (42915989..42925838)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42883545..42893583)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7-like 1 Neighboring gene chromosome 6 open reading frame 226 Neighboring gene canopy FGF signaling regulator 3 Neighboring gene ribosomal protein L24 pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids within the CHARGE Consortium.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pre T-cell antigen receptor alpha
Names
pre T-cell antigen receptor alpha
pT-alpha-TCR
pre-T-cell receptor alpha chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029636.1 

    Range
    5001..14850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243168.1NP_001230097.1  pre T-cell antigen receptor alpha isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK130819, AW014894, BC153829, U36759
    Consensus CDS
    CCDS75457.1
    UniProtKB/Swiss-Prot
    Q6ISU1
    UniProtKB/TrEMBL
    Q6ZNR1
    Related
    ENSP00000477815, ENST00000616441
    Conserved Domains (1) summary
    pfam15028
    Location:20188
    PTCRA; Pre-T-cell antigen receptor
  2. NM_001243169.1NP_001230098.1  pre T-cell antigen receptor alpha isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses alternate in-frame splice junctions at the 5' ends of two exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (3) contains an alternate internal segment but lacks two others compared to isoform 1.
    Source sequence(s)
    AF165312, AW014894, BC153829, U36759
    Consensus CDS
    CCDS59019.1
    UniProtKB/Swiss-Prot
    Q6ISU1
    Related
    ENSP00000409550, ENST00000441198
    Conserved Domains (1) summary
    cl11960
    Location:35148
    Ig; Immunoglobulin domain
  3. NM_001243170.1NP_001230099.1  pre T-cell antigen receptor alpha isoform 4 precursor

    See proteins identical to NP_001230099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) lacks two internal segments compared to isoform 1.
    Source sequence(s)
    AF101436, AW014894, BC153829, U36759
    Consensus CDS
    CCDS59020.1
    UniProtKB/Swiss-Prot
    Q6ISU1
    Related
    ENSP00000392288, ENST00000446507
    Conserved Domains (1) summary
    cl11960
    Location:1566
    Ig; Immunoglobulin domain
  4. NM_138296.2NP_612153.2  pre T-cell antigen receptor alpha isoform 2 precursor

    See proteins identical to NP_612153.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AW014894, BC100771, U36759, U38996
    Consensus CDS
    CCDS4874.1
    UniProtKB/Swiss-Prot
    Q6ISU1
    Related
    ENSP00000304447, OTTHUMP00000016409, ENST00000304672, OTTHUMT00000040565
    Conserved Domains (1) summary
    pfam15028
    Location:20173
    PTCRA; Pre-T-cell antigen receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    42601262..42611014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    42915989..42925838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    42886198..42896045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)