Format

Send to:

Choose Destination

Mlph melanophilin [ Mus musculus (house mouse) ]

Gene ID: 171531, updated on 8-May-2016
Official Symbol
Mlphprovided by MGI
Official Full Name
melanophilinprovided by MGI
Primary source
MGI:MGI:2176380
See related
Ensembl:ENSMUSG00000026303 Vega:OTTMUSG00000022397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ln; l1Rk3; Slac-2a; AW228792; D1Wsu84e; l(1)-3Rk; 2210418F23Rik; 5031433I09Rik
Orthologs
Location:
1 D; 1 45.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (90915022..90951142)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (92811677..92847719)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene collagen, type VI, alpha 3 Neighboring gene predicted gene, 35381 Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Chemically induced (other) (1) 
  • Chemically induced (ENU) (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Rab GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Rab GTPase binding ISO
Inferred from Sequence Orthology
more info
 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule plus-end binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
melanosome IDA
Inferred from Direct Assay
more info
PubMed 
melanosome TAS
Traceable Author Statement
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
melanophilin
Names
exophilin-3
leaden protein
slaC2-a
slp homolog lacking C2 domains a
synaptotagmin-like protein 2a

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053015.3NP_443748.2  melanophilin

    See identical proteins and their annotated locations for NP_443748.2

    Status: VALIDATED

    Source sequence(s)
    AC118682, AK019883, AK148274
    Consensus CDS
    CCDS15155.1
    UniProtKB/Swiss-Prot
    Q91V27
    UniProtKB/TrEMBL
    A0A0R4J075
    Related
    ENSMUSP00000027528, OTTMUSP00000025451, ENSMUST00000027528, OTTMUST00000053516
    Conserved Domains (2) summary
    pfam04698
    Location:445497
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cd15752
    Location:62137
    FYVE_SlaC2-a; FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    90915022..90951142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529231.2XP_006529294.1  

    Conserved Domains (2) summary
    pfam04698
    Location:444496
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cd15752
    Location:62137
    FYVE_SlaC2-a; FYVE-related domain found in Slp homolog lacking C2 domains a (SlaC2-a) and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    93860662..93896365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)