Smad7 MAD homolog 7 (Drosophila) [Mus musculus] - Gene

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Summary

Official Symbol: Smad7provided by MGI
Official Full Name: MAD homolog 7 (Drosophila)provided by MGI
Primary source: MGI:1100518
See related: Ensembl:ENSMUSG00000025880; Vega:OTTMUSG00000024306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Madh7

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Genomic context

Location :: 18 E2; 18

Sequence :: Chromosome: 18; NC_000084.6 (75367365..75395934)

See Smad7 in Epigenomics, MapViewer

Chromosome 18 - NC_000084.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Smad4 may be a key regulator for the diverse roles of TGF-beta1 in inflammation and fibrogenesis by interacting with Smad7 and Smad3 to influence their transcriptional activities in renal inflammation and fibrosis.
Title: Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.
Data show that Smad7 overexpression increased colitis severity, but the mice nevertheless developed fewer tumors than nontransgenic mice.
Title: Smad7 expression in T cells prevents colitis-associated cancer.
Epidermal Smad7 overexpression accelerated wound healing.
Title: Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing.
CYLD regulates TGF-beta signaling function in T cells and the development of Tregs through deubiquitination of Smad7
Title: The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.
In vivo evidence revealing that endogenous Smad7 plays an important role in liver function and alcohol-induced liver injury.
Title: Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury.
Smad2 and Smad3 were endogenously activated and expression of Smad7 was inhibited during the fusion process of palatal shelves.
Title: Inhibition of Smad signaling is implicated in cleft palate induced by all-trans retinoic acid.
Tenascin-x protein expression was negatively correlated with EF, FS, smad-7 and PPARgamma, and positively correlated with LVEDd, CVF, smad-3, and TGFbeta(1) (P < 0.001).
Title: Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-β1 and peroxisome proliferator-activated receptor γ in alcoholic cardiomyopathy.
Smad7 plays a protective role in diabetic renal injury.
Title: The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential.
Smad7 and Smad6 significantly promoted the differentiation of mouse embryonic stem (ES) cells into ciliated cells.
Title: Inhibitory Smad proteins promote the differentiation of mouse embryonic stem cells into ependymal-like ciliated cells.
Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects
Title: Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.

Submit: New GeneRIF Correction See all (58)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Gene trapped (1)

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_032569.1	NP_031769.1	Col1a2	BIND	PubMed	Smad7 interacts with Type I Collagen. This interaction was modelled on a demonstrated interaction between frog Smad7 and mouse Type I Collagen.
NP_032569.1	NP_034060.1	Col3a1	BIND	PubMed	Smad7 interacts with Type III Collagen. This interaction was modelled on a demonstrated interaction between frog Smad7 and mouse Type III Collagen.
NP_032569.1	NP_031763.1	Col5a2	BIND	PubMed	Smad7 interacts with Type V Collagen. This interaction was modelled on a demonstrated interaction between frog Smad7 and mouse Type V Collagen.
NP_032569.1	NP_031866.1	Ddx5	BIND	PubMed	Smad7 interacts with p68. This interaction was modelled on a demonstrated interaction between Xenopus Smad7 and mouse p68.
NP_032569.1	NP_034221.3	Dvl1	BIND	PubMed	Smad7 interacts with Dvl-1. This interaction was modelled on a demonstrated interaction between african clawed frog Smad7 and mouse Dvl-1.
NP_032569.1	NP_076232.1	Eif4enif1	BIND	PubMed	4-ET interacts with Smad7. This interaction was modelled on a demonstrated interaction between mouse 4-ET and frog Smad7.
NP_032569.1	NP_296369.1	Pard3	BIND	PubMed	Smad7 interacts with Par-3. This interaction was modelled on a demonstrated interaction between frog Smad7 and mouse Par-3.
NP_032569.1	NP_663463.1	Pex6	BIND	PubMed	Pex6 interacts with Smad7. This interaction was modelled on a demonstrated interaction between mouse Pex6 and frog Smad7.
NP_032569.1	NP_084385.1	Sf3b2	BIND	PubMed	SF3b2 interacts with Smad7. This interaction was modelled on a demonstrated interaction between mouse SF3b2 and frog Smad7.
NP_032569.1	XP_127858.1		BIND	PubMed	ZNF198 interacts with Smad7. This interaction was modelled on a demonstrated interaction between mouse ZNF198 and frog Smad7.
BioGRID:201280	BioGRID:106606	ACVR1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:198287	Axin1	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:201280	BioGRID:198288	Axin2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:107125	BMPR1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:107126	BMPR1B	BioGRID	PubMed	Affinity Capture-Luminescence
BioGRID:201280	BioGRID:220311	Rnf111	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-Luminescence
BioGRID:201280	BioGRID:122265	SMURF2	BioGRID	PubMed	Affinity Capture-Luminescence
BioGRID:201280	BioGRID:217743	Smurf1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:211376	Smurf2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201280	BioGRID:112904	TGFBR1	BioGRID	PubMed	Affinity Capture-Luminescence; Affinity Capture-Western
BioGRID:201280	BioGRID:115684	YAP1	BioGRID	PubMed	Two-hybrid
BioGRID:201280	BioGRID:88941	tob1a	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
I-SMAD binding	ISO Inferred from Sequence Orthology more info
activin binding	ISO Inferred from Sequence Orthology more info
beta-catenin binding	ISO Inferred from Sequence Orthology more info
collagen binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	ISO Inferred from Sequence Orthology more info
type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
adherens junction assembly	ISO Inferred from Sequence Orthology more info
artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cellular protein complex localization	ISO Inferred from Sequence Orthology more info
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of pathway-restricted SMAD protein phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of ubiquitin-protein ligase activity	ISO Inferred from Sequence Orthology more info
pathway-restricted SMAD protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
protein stabilization	ISO Inferred from Sequence Orthology more info
regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
regulation of cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
regulation of transforming growth factor beta receptor signaling pathway	IC Inferred by Curator more info	PubMed
regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
regulation of ventricular cardiomyocyte membrane depolarization	IC Inferred by Curator more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
intracellular	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: mothers against decapentaplegic homolog 7

Names: mothers against decapentaplegic homolog 7; madh8; SMAD 7; MAD homolog 8; SMAD family member 7; mothers against DPP homolog 7; mothers against DPP homolog 8; mothers against decapentaplegic homolog 8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042660.1 → NP_001036125.1 mothers against decapentaplegic homolog 7

Status: VALIDATED

Source sequence(s)

AC120156, AJ000550

Consensus CDS

CCDS37860.1

UniProtKB/TrEMBL

B2RPW6

UniProtKB/Swiss-Prot

O35253

Related

ENSMUSP00000026999, OTTMUSP00000028959, ENSMUST00000026999, OTTMUST00000059530

Conserved Domains (2) summary

cd10500
Location:254 – 424
Blast Score: 942

MH2_SMAD_7; C-terminal Mad Homology 2 (MH2) domain in SMAD7

cl00055
Location:91 – 207
Blast Score: 376

MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000084.6 Reference GRCm38 C57BL/6J

Range

75367365..75395934

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000040.1 Alternate Mm_Celera

Range

76602062..76630688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008543.1: Suppressed sequence

Description

NM_008543.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate, and there is no transcriptional support for this variant.

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC120156.9 (55543..84112)	None
genomic	AF167314.1	None	129/SvJ
genomic	CH466528.2	EDL09492.1	mixed
		EDL09493.1	mixed
mRNA	AB221688.1	None
mRNA	AF015260.1	AAB81353.1
mRNA	AJ000550.1	CAA04182.1
mRNA	AJ000551.1	CAA04183.1
mRNA	AK013237.1	None	C57BL/6J
mRNA	AK133505.1	None	C57BL/6J
mRNA	BC137638.1	AAI37639.1