RHOV ras homolog family member V [Homo sapiens] - Gene

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Summary

Official Symbol: RHOVprovided by HGNC
Official Full Name: ras homolog family member Vprovided by HGNC
Primary source: HGNC:18313
See related: Ensembl:ENSG00000104140; HPRD:10191; Vega:OTTHUMG00000130134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CHP; ARHV; WRCH2

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Genomic context

Location :: 15q13.3

Sequence :: Chromosome: 15; NC_000015.9 (41164412..41166487, complement)

See RHOV in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrate a novel mechanism of signal termination mediated by the Rho-family GTPases Chp and Cdc42, which results in ubiquitin-mediated degradation of one of their direct effectors, Pak1.
Title: Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.
cloning and characterization of WRCH2 on human chromosome 15q15
Title: Molecular cloning and characterization of WRCH2 on human chromosome 15q15.
Data suggest that Chp is implicated in cell transformation, and the unique amino and carboxyl termini of Chp represent atypical mechanisms of regulation of Rho GTPase function.
Title: Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info
endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: rho-related GTP-binding protein RhoV

Names: rho-related GTP-binding protein RhoV; WRCH-2; CDC42-like GTPase 2; WRCH1-related GTPase; GTP-binding protein-like 2; Rho GTPase-like protein ARHV; Wnt-1 regulated Cdc42 homolog 2; Wnt-1 responsive Cdc42 homolog 2; ras homolog gene family, member V

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133639.3 → NP_598378.3 rho-related GTP-binding protein RhoV

Status: VALIDATED

Source sequence(s)

AC025166, BC112945

Consensus CDS

CCDS10068.1

UniProtKB/Swiss-Prot

Q96L33

Related

ENSP00000220507, OTTHUMP00000160629, ENST00000220507, OTTHUMT00000252442

Conserved Domains (1) summary

cd04130
Location:32 – 205
Blast Score: 872

Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

41164412..41166487, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

18012645..18014720, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC025166.7 (80326..81912)	None
genomic	CH471125.1	EAW92459.1
		EAW92460.1
mRNA	AB079131.1	BAB86363.1
mRNA	AY059636.1	AAL17966.1
mRNA	BC019353.1	AAH19353.1
mRNA	BC105020.1	AAI05021.1
mRNA	BC105022.1	AAI05023.1
mRNA	BC112945.1	AAI12946.2