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Lyst lysosomal trafficking regulator [ Mus musculus (house mouse) ]

Gene ID: 17101, updated on 28-May-2016
Official Symbol
Lystprovided by MGI
Official Full Name
lysosomal trafficking regulatorprovided by MGI
Primary source
MGI:MGI:107448
See related
Ensembl:ENSMUSG00000019726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bg; beige; D13Sfk13
Orthologs
Location:
13 A1; 13 5.28 cM
Exon count:
55
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (13590339..13778803)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (13682676..13869707)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene embryonic H3 histone Neighboring gene nidogen 1 Neighboring gene predicted gene, 30836 Neighboring gene guanine nucleotide binding protein (G protein), gamma 4 Neighboring gene predicted gene 7441

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (9)  1 citation
  • Targeted (1) 
  • Chemically induced (ENU) (9)  1 citation
  • Radiation induced (1) 

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport via multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mast cell secretory granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
melanosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
pigment granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretion of lysosomal enzymes IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
lysosomal-trafficking regulator
Names
CHS1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010748.2NP_034878.2  lysosomal-trafficking regulator

    See identical proteins and their annotated locations for NP_034878.2

    Status: VALIDATED

    Source sequence(s)
    CT010431, U70015
    Consensus CDS
    CCDS36597.1
    UniProtKB/Swiss-Prot
    P97412
    UniProtKB/TrEMBL
    G5E8Q0
    Related
    ENSMUSP00000106188, ENSMUST00000110559
    Conserved Domains (4) summary
    cd06071
    Location:31183408
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:35263764
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:34633764
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:29983103
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    13590339..13778803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516563.2XP_006516626.1  

  2. XM_006516561.1XP_006516624.1  

    Conserved Domains (4) summary
    cd06071
    Location:31703460
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:35783816
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:35153816
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:30503155
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
  3. XM_006516562.1XP_006516625.1  

    Conserved Domains (4) summary
    cd06071
    Location:31693459
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:35773815
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:35143815
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01201
    Location:30493154
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    13893712..14083127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)