Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog [Mus musculus] - Gene

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Summary

Official Symbol: Lynprovided by MGI
Official Full Name: Yamaguchi sarcoma viral (v-yes-1) oncogene homologprovided by MGI
Primary source: MGI:96892
Locus tag: RP23-49A12.2
See related: Ensembl:ENSMUSG00000042228; Vega:OTTMUSG00000004398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hck-2; p53Lyn; p56Lyn; AA407514

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Genomic context

Location :: 4 A1; 4 0.0 cM

Sequence :: Chromosome: 4; NC_000070.6 (3678121..3791612)

See Lyn in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lyn-deficient T2 and follicular B cells expressed elevated levels of the pro-apoptotic factor Bim.
Title: Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.
protein deficiency affects B-cell maturation as well as survival
Title: Lyn deficiency affects B-cell maturation as well as survival.
Results demonstrate a crucial interplay of Lyn, SHIP, and p85alpha in regulating the normal growth and maturation of bone marrow-derived mast cells, in part by regulating the activation of AKT and the expression of Mitf.
Title: Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.
dominant immunosuppressive function of B-cell-derived IL-10 in the Lyn-deficient model of autoimmunity, extending our current understanding of the role of IL-10 and IL-10-producing B cells in systemic lupus erythematosus
Title: B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
A model in which PECAM-1/SHP-2 complexes, formed in a Lyn-dependent manner, suppress GPVI signaling.
Title: Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.
Despite possessing enhanced killing, alveolar macrophage Lyn/Fgr/Hck-deficient (triple-knockout) mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Title: IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
The results of this study suggested a novel role for Lyn kinase in the regulation of DA release in the mesolimbic system, which leads to the control of alcohol reward.
Title: Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward.
Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
Title: Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.
Although Lyn is involved in dampening the cytokine Toll-like receptor response, Lyn-deficient macrophages and mice still develop microbial tolerance.
Title: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
Lyn B isozyme differs from Lyn A in its association with negative regulatory lipid phosphatase SHIP-1 and in the regulation of calcium responses.
Title: Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.

Submit: New GeneRIF Correction See all (59)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Chemically induced (ENU) (2) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
AAA39471.1	NP_034279.2	Epor	BIND	PubMed	EpoR is phosphorylated by LynA.
AAA39471.1	NP_032251.1	Hcls1	BIND	PubMed	LynA interacts with HS1.
AAA39471.1	NP_032439.1	Jak2	BIND	PubMed	Jak2 interacts with LynA.
NP_034877.1	NP_033973.2	Ctla4	BIND	PubMed	Lyn interacts with CTLA-4. This interaction was modelled on a demonstrated interaction between human Lyn and mouse CTLA-4.
NP_034877.1	NP_034279.2	Epor	BIND	PubMed	EpoR is phosphorylated by LynB.
NP_034877.1	NP_031991.2	Evl	BIND	PubMed	EVL interacts with Lyn SH3 domain. This interaction was modeled on a demonstrated interaction between mouse EVL and Lyn from an unspecified species.
NP_034877.1	NP_032439.1	Jak2	BIND	PubMed	Jak2 interacts with LynB.
BioGRID:201256	BioGRID:220469	Pag1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:201256	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enzyme binding	ISO Inferred from Sequence Orthology more info
erythropoietin receptor binding	TAS Traceable Author Statement more info	PubMed
glycosphingolipid binding	ISO Inferred from Sequence Orthology more info
integrin binding	ISO Inferred from Sequence Orthology more info
ion channel binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphoprotein binding	ISO Inferred from Sequence Orthology more info
platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	ISO Inferred from Sequence Orthology more info
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
receptor binding	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
Fc receptor mediated inhibitory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
Fc receptor mediated stimulatory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
cytokine secretion	ISO Inferred from Sequence Orthology more info
dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
hemoglobin biosynthetic process	TAS Traceable Author Statement more info	PubMed
hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
immune response-regulating cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response	IEA Inferred from Electronic Annotation more info
innate immune response	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info
negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of intracellular protein kinase cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of mast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of myeloid leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info
negative regulation of toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info
neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
platelet degranulation	IMP Inferred from Mutant Phenotype more info
positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular component movement	ISO Inferred from Sequence Orthology more info
positive regulation of dendritic cell apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of mast cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
positive regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of B cell apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cytokine secretion	IMP Inferred from Mutant Phenotype more info
regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info
regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
tolerance induction to self antigen	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
alpha2-beta1 integrin complex	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	ISO Inferred from Sequence Orthology more info
membrane raft	ISO Inferred from Sequence Orthology more info
mitochondrial crista	ISO Inferred from Sequence Orthology more info
mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
mitochondrial membrane	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: tyrosine-protein kinase Lyn

Names: tyrosine-protein kinase Lyn; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

NP_001104566.1

EC 2.7.10.2

NP_034877.2

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111096.1 → NP_001104566.1 tyrosine-protein kinase Lyn isoform A

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AK028112, AK152199, BY743506

Consensus CDS

CCDS51109.1

UniProtKB/Swiss-Prot

P25911

UniProtKB/TrEMBL

Q3TCS3

UniProtKB/TrEMBL

Q8CEI0

Related

ENSMUSP00000038838, OTTMUSP00000004774, ENSMUST00000041377, OTTMUST00000009967

Conserved Domains (4) summary

cd00174
Location:67 – 120
Blast Score: 164

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd05072
Location:240 – 500
Blast Score: 1416

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

cd10364
Location:125 – 225
Blast Score: 534

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

pfam07714
Location:247 – 497
Blast Score: 1052

Pkinase_Tyr; Protein tyrosine kinase
NM_010747.2 → NP_034877.2 tyrosine-protein kinase Lyn isoform B

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).

Source sequence(s)

AK028112, AK153038, BY743506

Consensus CDS

CCDS17939.1

UniProtKB/TrEMBL

Q3U6Q5

UniProtKB/TrEMBL

Q8CEI0

Related

ENSMUSP00000100075, OTTMUSP00000004775, ENSMUST00000103010, OTTMUST00000009968

Conserved Domains (4) summary

cd00174
Location:46 – 99
Blast Score: 163

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd05072
Location:219 – 479
Blast Score: 1413

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

cd10364
Location:104 – 204
Blast Score: 535

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

pfam07714
Location:226 – 476
Blast Score: 1049

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38 C57BL/6J

Range

3678121..3791612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1

Range

3440611..3442642, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)
NW_001037471.1

Range

915..4801, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL772401.22	CAM25742.1
		CAM25743.1
genomic	CH466538.2	EDL05715.1	mixed
		EDL05716.1	mixed
genomic	X77604.1	None	129/Sv
mRNA	AK028112.1	BAC25753.1	C57BL/6J
mRNA	AK151914.1	None	C57BL/6J
mRNA	AK152199.1	BAE31028.1	C57BL/6J
mRNA	AK153038.1	BAE31669.1	C57BL/6J
mRNA	AK170561.1	BAE41882.1	NOD
mRNA	AK172492.1	None	NOD
mRNA	BC003253.1	AAH03253.1	FVB/N
mRNA	BC031547.1	AAH31547.1	CZECHII
mRNA	BC157998.1	AAI57999.1
mRNA	BY743506.1	None	C57BL/6J
mRNA	M33426.1	AAA40017.1
mRNA	M57696.1	AAA39471.1	DBA/2
mRNA	M57697.1	AAA39472.1	DBA/2
mRNA	M64608.1	AAA39470.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P25911.4	GenPept	UniProtKB/Swiss-Prot:P25911
Q05DV0	GenPept	UniProtKB/TrEMBL:Q05DV0
Q3TCS3	GenPept	UniProtKB/TrEMBL:Q3TCS3
Q3U6Q5	GenPept	UniProtKB/TrEMBL:Q3U6Q5
Q8CEI0	GenPept	UniProtKB/TrEMBL:Q8CEI0