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Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [ Mus musculus (house mouse) ]

Gene ID: 170768, updated on 28-May-2016
Official Symbol
Pfkfb3provided by MGI
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by MGI
Primary source
MGI:MGI:2181202
See related
Ensembl:ENSMUSG00000026773 Vega:OTTMUSG00000011314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
iPFK-2; uPFK-2; E330010H22Rik
Orthologs
Location:
2; 2 A1
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (11471430..11554071, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (11393057..11475556, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31990 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10851 Neighboring gene RNA binding motif protein 17 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
6-phosphofructo-2-kinase activity ISO
Inferred from Sequence Orthology
more info
 
fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fructose 2,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Names
inducible 6-phosphofructo-2-kinase
NP_001171223.1
NP_001171224.1
NP_001171225.1
NP_001171226.1
NP_001171227.1
NP_001171228.1
NP_001171229.1
NP_573495.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177752.1NP_001171223.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1

    See identical proteins and their annotated locations for NP_001171223.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks 4 exons in the 3' coding region, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778, EU034675
    Consensus CDS
    CCDS50498.1
    UniProtKB/TrEMBL
    A7UAK4, Q7TS91
    Related
    ENSMUSP00000138893, OTTMUSP00000069424, ENSMUST00000183869, OTTMUST00000129165
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  2. NM_001177753.1NP_001171224.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2

    See identical proteins and their annotated locations for NP_001171224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778, EU034676
    Consensus CDS
    CCDS50501.1
    UniProtKB/TrEMBL
    A7UAK5, Q7TS91
    Related
    ENSMUSP00000142079, OTTMUSP00000069425, ENSMUST00000191668, OTTMUST00000129166
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  3. NM_001177754.1NP_001171225.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3

    See identical proteins and their annotated locations for NP_001171225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 3' coding region, compared to variant 2. The resulting isoform (3) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778, EU034677
    Consensus CDS
    CCDS79731.1
    UniProtKB/TrEMBL
    A2AUP5, Q7TS91
    Related
    ENSMUSP00000050926, OTTMUSP00000069426, ENSMUST00000049849, OTTMUST00000129167
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  4. NM_001177755.1NP_001171226.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 4

    See identical proteins and their annotated locations for NP_001171226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 3' coding region, compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778, EU034678
    Consensus CDS
    CCDS79732.1
    UniProtKB/TrEMBL
    Q3U3S6, Q7TS91
    Related
    ENSMUSP00000137130, OTTMUSP00000069423, ENSMUST00000179584, OTTMUST00000129162
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  5. NM_001177756.1NP_001171227.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 5

    See identical proteins and their annotated locations for NP_001171227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks one alternate exon in the 3' coding region, compared to variant 2. The resulting isoform (5) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778, EU034679
    Consensus CDS
    CCDS50500.1
    UniProtKB/TrEMBL
    A7UAK8, Q7TS91
    Related
    ENSMUSP00000126305, OTTMUSP00000069427, ENSMUST00000170196, OTTMUST00000026513
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  6. NM_001177757.1NP_001171228.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 7

    See identical proteins and their annotated locations for NP_001171228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region, compared to variant 2. The resulting isoform (7) lacks an internal segment, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778
    Consensus CDS
    CCDS50499.1
    UniProtKB/TrEMBL
    Q7TS91
    Related
    ENSMUSP00000028114, OTTMUSP00000012127, ENSMUST00000028114, OTTMUST00000026507
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase
  7. NM_001177758.1NP_001171229.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and 5' UTR, uses a distinct translation start codon, and lacks three alternate exons in the 3' coding region, compared to variant 2. The resulting isoform (8) has a distinct N-terminus, lacks an internal segment, and has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AK143330, AL831794, BC052400, BP764506, EU034678
    Consensus CDS
    CCDS79733.1
    UniProtKB/TrEMBL
    A0A0A6YY64, Q3U3S6, Q7TS91
    Related
    ENSMUSP00000142296, OTTMUSP00000069428, ENSMUST00000192949, OTTMUST00000129170
    Conserved Domains (2) summary
    cd07067
    Location:228414
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:4226
    6PF2K; 6-phosphofructo-2-kinase
  8. NM_133232.3NP_573495.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons in the 3' coding region, compared to variant 2. The resulting isoform (6) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BB553577, BC052400, BP764506, BY267778
    Consensus CDS
    CCDS15683.1
    UniProtKB/TrEMBL
    A2AUP1, Q7TS91
    Related
    ENSMUSP00000110495, OTTMUSP00000012128, ENSMUST00000114846, OTTMUST00000026508
    Conserved Domains (2) summary
    cd07067
    Location:248434
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:26246
    6PF2K; 6-phosphofructo-2-kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    11471430..11554071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497367.1XP_006497430.1  

    Conserved Domains (2) summary
    cd07067
    Location:228414
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:4226
    6PF2K; 6-phosphofructo-2-kinase
  2. XM_006497368.2XP_006497431.1  

    See identical proteins and their annotated locations for XP_006497431.1

    Conserved Domains (2) summary
    cd07067
    Location:209395
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:1207
    6PF2K; 6-phosphofructo-2-kinase
  3. XM_006497369.2XP_006497432.1  

    See identical proteins and their annotated locations for XP_006497432.1

    Conserved Domains (2) summary
    cd07067
    Location:209395
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:1207
    6PF2K; 6-phosphofructo-2-kinase

RNA

  1. XR_865927.1 RNA Sequence

    Related
    ENSMUST00000150086

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    11389848..11473089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172976.1: Suppressed sequence

    Description
    NM_172976.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.