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Lta4h leukotriene A4 hydrolase [ Mus musculus (house mouse) ]

Gene ID: 16993, updated on 8-May-2016
Official Symbol
Lta4hprovided by MGI
Official Full Name
leukotriene A4 hydrolaseprovided by MGI
Primary source
MGI:MGI:96836
See related
Ensembl:ENSMUSG00000015889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Orthologs
Location:
10; 10 C3
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (93453396..93484898)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (92916141..92947641)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene microRNA 7688 Neighboring gene nuclear encoded tRNA aspartic acid 8 (anticodon GTC) Neighboring gene histidine ammonia lyase Neighboring gene amidohydrolase domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
epoxide hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
leukotriene-A4 hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
leukotriene-A4 hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
 
peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
leukotriene A-4 hydrolase
Names
LTA-4 hydrolase
LTA4 hydrodase
NP_032543.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313897.1NP_001300826.1  leukotriene A-4 hydrolase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK134931, BF018223, BG807829, BY793553
    UniProtKB/Swiss-Prot
    P24527
    Conserved Domains (3) summary
    cd09599
    Location:6450
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam01433
    Location:21387
    Peptidase_M1; Peptidase family M1
    pfam09127
    Location:464510
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
  2. NM_008517.2NP_032543.2  leukotriene A-4 hydrolase isoform 1

    See identical proteins and their annotated locations for NP_032543.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK134931, AW121450, BY458968, BY793553
    Consensus CDS
    CCDS24125.1
    UniProtKB/Swiss-Prot
    P24527
    Related
    ENSMUSP00000016033, ENSMUST00000016033
    Conserved Domains (3) summary
    cd09599
    Location:6450
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:464608
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    TIGR02411
    Location:6608
    leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    93453396..93484898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513286.2XP_006513349.1  

    Conserved Domains (3) summary
    cd09599
    Location:6450
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam01433
    Location:21387
    Peptidase_M1; Peptidase family M1
    pfam09127
    Location:464510
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    95436799..95470679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)