Format

Send to:

Choose Destination

Sh2b3 SH2B adaptor protein 3 [ Mus musculus (house mouse) ]

Gene ID: 16923, updated on 8-May-2016
Official Symbol
Sh2b3provided by MGI
Official Full Name
SH2B adaptor protein 3provided by MGI
Primary source
MGI:MGI:893598
See related
Ensembl:ENSMUSG00000042594 Vega:OTTMUSG00000029807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lnk; AI429800
Summary
This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Orthologs
Location:
5 F; 5 61.99 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (121815481..121837655, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122267224..122286810, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene microRNA 7031 Neighboring gene predicted gene, 32422 Neighboring gene family with sequence similarity 109, member A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
SH2B adapter protein 3
Names
linker of T-cell receptor pathways
lymphocyte-specific adapter protein Lnk
signal transduction protein Lnk

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306126.1NP_001293055.1  SH2B adapter protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001293055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC113302, AK028796, BP762530
    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  2. NM_001306127.1NP_001293056.1  SH2B adapter protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001293056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC113302, AK028796, BP762530
    Consensus CDS
    CCDS19641.1
    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  3. NM_001306128.1NP_001293057.1  SH2B adapter protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC113302, AK028796, BP762530
    UniProtKB/TrEMBL
    D3Z3Y5
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:317413
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  4. NM_008507.4NP_032533.1  SH2B adapter protein 3 isoform 1

    See identical proteins and their annotated locations for NP_032533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC113302, AK028796, BP762530
    Consensus CDS
    CCDS19641.1
    UniProtKB/Swiss-Prot
    O09039
    Related
    ENSMUSP00000041611, OTTMUSP00000038368, ENSMUST00000040308, OTTMUST00000073988
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    121815481..121837655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530171.2XP_006530234.1  

    See identical proteins and their annotated locations for XP_006530234.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  2. XM_006530169.2XP_006530232.1  

    Related
    ENSMUSP00000083490, OTTMUSP00000038367, ENSMUST00000086310, OTTMUST00000073987
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  3. XM_006530173.2XP_006530236.1  

    See identical proteins and their annotated locations for XP_006530236.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  4. XM_011248183.1XP_011246485.1  

    See identical proteins and their annotated locations for XP_011246485.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  5. XM_006530172.1XP_006530235.1  

    See identical proteins and their annotated locations for XP_006530235.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  6. XM_006530170.2XP_006530233.1  

    See identical proteins and their annotated locations for XP_006530233.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
  7. XM_011248182.1XP_011246484.1  

    See identical proteins and their annotated locations for XP_011246484.1

    UniProtKB/Swiss-Prot
    O09039
    Conserved Domains (3) summary
    pfam08916
    Location:2277
    Phe_ZIP; Phenylalanine zipper
    cd10412
    Location:327423
    SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:168281
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    118907377..118942299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)