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Lmx1b LIM homeobox transcription factor 1 beta [ Mus musculus (house mouse) ]

Gene ID: 16917, updated on 8-May-2016
Official Symbol
Lmx1bprovided by MGI
Official Full Name
LIM homeobox transcription factor 1 betaprovided by MGI
Primary source
MGI:MGI:1100513
See related
Ensembl:ENSMUSG00000038765 Vega:OTTMUSG00000012589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LMX1.1; LMX1.2
Orthologs
Location:
2 B; 2 22.48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (33560965..33640992, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (33420056..33496031, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33642 Neighboring gene predicted gene, 39789 Neighboring gene Riken cDNA C130021I20 gene Neighboring gene predicted gene, 39790 Neighboring gene RIKEN cDNA 9430024E24 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC159172

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
embryonic limb morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
memory IGI
Inferred from Genetic Interaction
more info
PubMed 
midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
trabecular meshwork development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
LIM homeobox transcription factor 1-beta
Names
LIM homeo box transcription factor 1B
LIM/homeobox protein 1.2
LIM/homeobox protein LMX1B
LMX-1.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010725.2NP_034855.2  LIM homeobox transcription factor 1-beta

    See identical proteins and their annotated locations for NP_034855.2

    Status: VALIDATED

    Source sequence(s)
    AL929212
    Consensus CDS
    CCDS15944.1
    UniProtKB/Swiss-Prot
    O88609
    UniProtKB/TrEMBL
    A0A0R4J0I7
    Related
    ENSMUSP00000043616, OTTMUSP00000013489, ENSMUST00000041730, OTTMUST00000029994
    Conserved Domains (3) summary
    cd09371
    Location:3385
    LIM1_Lmx1b; The first LIM domain of Lmx1b
    cd09378
    Location:92146
    LIM2_Lmx1a_Lmx1b; The second LIM domain of Lmx1a and Lmx1b
    cd00086
    Location:197253
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    33560965..33640992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497746.2XP_006497809.1  

    Related
    ENSMUSP00000134944, OTTMUSP00000057744, ENSMUST00000176067, OTTMUST00000103373
    Conserved Domains (3) summary
    cd09371
    Location:62114
    LIM1_Lmx1b; The first LIM domain of Lmx1b
    cd09378
    Location:121175
    LIM2_Lmx1a_Lmx1b; The second LIM domain of Lmx1a and Lmx1b
    cd00086
    Location:226282
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_006497747.2XP_006497810.1  

    Conserved Domains (2) summary
    cd09378
    Location:151
    LIM2_Lmx1a_Lmx1b; The second LIM domain of Lmx1a and Lmx1b
    cd00086
    Location:102158
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    33269132..33345093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)