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Lipe lipase, hormone sensitive [ Mus musculus (house mouse) ]

Gene ID: 16890, updated on 8-May-2016
Official Symbol
Lipeprovided by MGI
Official Full Name
lipase, hormone sensitiveprovided by MGI
Primary source
MGI:MGI:96790
See related
Ensembl:ENSMUSG00000003123 Vega:OTTMUSG00000034139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSL; 4933403G17Rik
Orthologs
Location:
7 A3; 7 13.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (25379527..25398704, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26164546..26181006, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene multiple EGF-like-domains 8 Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene cornifelin Neighboring gene predicted gene, 38968 Neighboring gene chemokine (C-X-C motif) ligand 17 Neighboring gene GrpE-like 2, mitochondrial pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Fatty Acid Beta Oxidation, organism-specific biosystem (from WikiPathways)
    Fatty Acid Beta Oxidation, organism-specific biosystemComplete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics. This pathway was previously split into three parts p...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Regulation of lipolysis in adipocytes, organism-specific biosystem (from KEGG)
    Regulation of lipolysis in adipocytes, organism-specific biosystemLipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. ...
  • Triacylglyceride Synthesis, organism-specific biosystem (from WikiPathways)
    Triacylglyceride Synthesis, organism-specific biosystem
    Triacylglyceride Synthesis
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • triacylglycerol degradation, organism-specific biosystem (from BIOCYC)
    triacylglycerol degradation, organism-specific biosystem
    triacylglycerol degradation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
 
hormone-sensitive lipase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds ISO
Inferred from Sequence Orthology
more info
 
lipase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA primary transcript binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
triglyceride lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase I transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transcription initiation from RNA polymerase I promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
triglyceride catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
lipid particle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hormone-sensitive lipase
NP_001034596.1
NP_034849.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039507.2NP_001034596.1  hormone-sensitive lipase isoform 2

    See identical proteins and their annotated locations for NP_001034596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC169209
    Consensus CDS
    CCDS20982.1
    UniProtKB/Swiss-Prot
    P54310
    Related
    ENSMUSP00000050935, OTTMUSP00000046815, ENSMUST00000054301, OTTMUST00000086441
    Conserved Domains (2) summary
    pfam06350
    Location:1315
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:332434
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
  2. NM_010719.5NP_034849.2  hormone-sensitive lipase isoform 1

    See identical proteins and their annotated locations for NP_034849.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029984, BY513432
    Consensus CDS
    CCDS20981.1
    UniProtKB/Swiss-Prot
    P54310
    Related
    ENSMUSP00000003207, OTTMUSP00000046816, ENSMUST00000003207, OTTMUST00000086442
    Conserved Domains (2) summary
    pfam06350
    Location:44358
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:375477
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    25379527..25398704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539570.1XP_006539633.1  

    UniProtKB/TrEMBL
    E9Q4M2
    Related
    ENSMUSP00000123485, OTTMUSP00000046817, ENSMUST00000149349, OTTMUST00000086443
    Conserved Domains (4) summary
    pfam05887
    Location:26103
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam06350
    Location:314628
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    pfam07859
    Location:658806
    Abhydrolase_3; alpha/beta hydrolase fold
    cl21494
    Location:645747
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
  2. XM_006539571.1XP_006539634.1  

    See identical proteins and their annotated locations for XP_006539634.1

    UniProtKB/Swiss-Prot
    P54310
    Conserved Domains (2) summary
    pfam06350
    Location:1315
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:332434
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...
  3. XM_006539572.2XP_006539635.1  

    See identical proteins and their annotated locations for XP_006539635.1

    UniProtKB/Swiss-Prot
    P54310
    Related
    ENSMUSP00000145665, OTTMUSP00000074603, ENSMUST00000206861, OTTMUST00000143068
    Conserved Domains (2) summary
    pfam06350
    Location:1315
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:332434
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    19994853..20011313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)