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Lig1 ligase I, DNA, ATP-dependent [ Mus musculus (house mouse) ]

Gene ID: 16881, updated on 21-May-2016
Official Symbol
Lig1provided by MGI
Official Full Name
ligase I, DNA, ATP-dependentprovided by MGI
Primary source
MGI:MGI:101789
See related
Ensembl:ENSMUSG00000056394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LigI; AL033288
Orthologs
Location:
7 A1; 7 7.82 cM
Exon count:
30
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (13277313..13311427)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (13864175..13896776)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 89 Neighboring gene vomeronasal 1 receptor, pseudogene 69 Neighboring gene RIKEN cDNA 6330408A02 gene Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent) Neighboring gene ribosomal protein S8, pseudogene 4 Neighboring gene phospholipase A2, group IVC (cytosolic, calcium-independent), pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA ligase (ATP) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA ligation involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Okazaki fragment processing involved in mitotic DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
base-excision repair ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA ligase 1
Names
DNA ligase I
polydeoxyribonucleotide synthase [ATP] 1
NP_001076657.1
NP_001186239.1
NP_034845.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083188.1NP_001076657.1  DNA ligase 1

    See identical proteins and their annotated locations for NP_001076657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses a different segment for its 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK168643, BE996000
    UniProtKB/TrEMBL
    Q3U4X8
    Related
    ENSMUSP00000126525, ENSMUST00000165964
    Conserved Domains (4) summary
    cd07969
    Location:768913
    OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
    cd07900
    Location:545763
    Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
    PLN03113
    Location:187928
    PLN03113; DNA ligase 1; Provisional
    pfam04675
    Location:301479
    DNA_ligase_A_N; DNA ligase N terminus
  2. NM_001199310.1NP_001186239.1  DNA ligase 1

    See identical proteins and their annotated locations for NP_001186239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC138541, BE996000
    UniProtKB/TrEMBL
    Q3U4X8
    Related
    ENSMUSP00000136972, ENSMUST00000177588
    Conserved Domains (4) summary
    cd07969
    Location:768913
    OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
    cd07900
    Location:545763
    Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
    PLN03113
    Location:187928
    PLN03113; DNA ligase 1; Provisional
    pfam04675
    Location:301479
    DNA_ligase_A_N; DNA ligase N terminus
  3. NM_010715.2NP_034845.2  DNA ligase 1

    See identical proteins and their annotated locations for NP_034845.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC161792, AK161793, BE996000, BY099263, U04674
    UniProtKB/Swiss-Prot
    P37913
    UniProtKB/TrEMBL
    Q3TSU8, Q3U4X8
    Related
    ENSMUSP00000096411, ENSMUST00000098814
    Conserved Domains (4) summary
    cd07969
    Location:768913
    OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
    cd07900
    Location:545763
    Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
    PLN03113
    Location:187928
    PLN03113; DNA ligase 1; Provisional
    pfam04675
    Location:301479
    DNA_ligase_A_N; DNA ligase N terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    13277313..13311427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    10893993..10928085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)