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Lifr leukemia inhibitory factor receptor [ Mus musculus (house mouse) ]

Gene ID: 16880, updated on 19-Mar-2015
Official Symbol
Lifrprovided by MGI
Official Full Name
leukemia inhibitory factor receptorprovided by MGI
Primary source
MGI:MGI:96788
See related
Ensembl:ENSMUSG00000054263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIF; AW061234; A230075M04Rik
Orthologs
See Lifr in MapViewer
Location:
15 A1; 15 3.46 cM
Exon count:
25
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (7090611..7197489)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (7079572..7147489)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30663 Neighboring gene predicted gene, 30971 Neighboring gene EGF-like, fibronectin type III and laminin G domains Neighboring gene FK506 binding protein 3 pseudogene Neighboring gene uncharacterized LOC105245880 Neighboring gene uncharacterized LOC105245879

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
leukemia inhibitory factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to oncostatin-M receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ciliary neurotrophic factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leukemia inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
oncostatin-M-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
organ regeneration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
leukemia inhibitory factor receptor
Names
leukemia inhibitory factor receptor
D-factor/LIF receptor
LIF receptor
LIF-R
leukemia inhibitory factor receptor alpha chain
soluble differentiation-stimulating factor receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113386.1NP_001106857.1  leukemia inhibitory factor receptor isoform 2 precursor

    See proteins identical to NP_001106857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC104553, AK145864, BY716975
    Consensus CDS
    CCDS49577.1
    UniProtKB/Swiss-Prot
    P42703
    UniProtKB/TrEMBL
    Q3UKU5
    Related
    ENSMUSP00000131434, ENSMUST00000164529
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:331367
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_013584.2NP_038612.1  leukemia inhibitory factor receptor isoform 1 precursor

    See proteins identical to NP_038612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104553, AC158747
    Consensus CDS
    CCDS27369.1
    UniProtKB/Swiss-Prot
    P42703
    Related
    ENSMUSP00000126137, ENSMUST00000171588
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:331367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    7090611..7197489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519969.2XP_006520032.1  

    See proteins identical to XP_006520032.1

    UniProtKB/Swiss-Prot
    P42703
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:331367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_006519967.2XP_006520030.1  

    See proteins identical to XP_006520030.1

    UniProtKB/Swiss-Prot
    P42703
    Related
    ENSMUSP00000064551, ENSMUST00000067190
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:331367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_011245325.1XP_011243627.1  

    See proteins identical to XP_011243627.1

    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:331367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006519970.2XP_006520033.1  

    See proteins identical to XP_006520033.1

    UniProtKB/Swiss-Prot
    P42703
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:331367
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  5. XM_006519971.2XP_006520034.1  

    See proteins identical to XP_006520034.1

    UniProtKB/Swiss-Prot
    P42703
    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:331367
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  6. XM_011245326.1XP_011243628.1  

    See proteins identical to XP_011243628.1

    Conserved Domains (2) summary
    cd00063
    Location:428525
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:331367
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    6977793..7045762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)