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Ldhb lactate dehydrogenase B [ Mus musculus (house mouse) ]

Gene ID: 16832, updated on 8-May-2016
Official Symbol
Ldhbprovided by MGI
Official Full Name
lactate dehydrogenase Bprovided by MGI
Primary source
MGI:MGI:96763
See related
Ensembl:ENSMUSG00000030246 Vega:OTTMUSG00000016379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldh2; H-Ldh; LDH-B; LDH-H; Ldh-2; AI790582
Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]
Orthologs
Location:
6 G2; 6 74.17 cM
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (142490249..142507957, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142438769..142456463, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 Neighboring gene predicted gene, 38919 Neighboring gene predicted gene, 38920

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
NAD binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD metabolic process ISO
Inferred from Sequence Orthology
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lactate biosynthetic process from pyruvate IC
Inferred by Curator
more info
PubMed 
lactate metabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
L-lactate dehydrogenase B chain
Names
LDH heart subunit
lactate dehydrogenase 2, B chain
NP_001289694.1
NP_032518.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302765.1NP_001289694.1  L-lactate dehydrogenase B chain isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and a different 3' UTR compared to variant 1. The encoded isoform (2) is shorter with a distinct C-terminus compared to isoform Ldhb.
    Source sequence(s)
    AK019391, BC046755, CX208147
    UniProtKB/Swiss-Prot
    P16125
    Conserved Domains (1) summary
    cd05293
    Location:20246
    LDH_1; A subgroup of L-lactate dehydrogenases
  2. NM_001316322.1NP_001303251.1  L-lactate dehydrogenase B chain isoform Ldhbx

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon (nt 1114-1116), while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon (nt 1135-1137). This RefSeq represents the longer, C-terminally extended isoform, which is localized in the peroxisomes. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK019391, BC046755
    UniProtKB/Swiss-Prot
    P16125
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:26326
    L-LDH-NAD; L-lactate dehydrogenase
  3. NM_008492.3NP_032518.1  L-lactate dehydrogenase B chain isoform Ldhb

    See identical proteins and their annotated locations for NP_032518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon (nt 1114-1116), while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon (nt 1135-1137). This RefSeq represents the shorter isoform, which is localized in the cytosol.
    Source sequence(s)
    AK019391, BC046755
    Consensus CDS
    CCDS20684.1
    UniProtKB/Swiss-Prot
    P16125
    Related
    ENSMUSP00000032373, OTTMUSP00000017612, ENSMUST00000032373, OTTMUST00000039419
    Conserved Domains (2) summary
    cd05293
    Location:20330
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:26326
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    142490249..142507957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    145551908..145569616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)