Stmn1 stathmin 1 [Mus musculus] - Gene

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Summary

Official Symbol: Stmn1provided by MGI
Official Full Name: stathmin 1provided by MGI
Primary source: MGI:96739
See related: Ensembl:ENSMUSG00000028832; Vega:OTTMUSG00000010830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 19k; Lag; P18; P19; Pig; Smn; Op18; Pp17; Pp18; Pp19; Pr22; Lap18

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Genomic context

Location :: 4 D3; 4 65.7 cM

Sequence :: Chromosome: 4; NC_000070.6 (134468320..134473843)

See Stmn1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Stathmin, which alters microtubule dynamics, plays an essential role in maintenance of postnatal bone mass by regulating both osteoblast and osteoclast functions in bone.
Title: Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice.
These results provide evidence that stathmin-1 expression in uNK cells at the maternal-fetal interface may help modulate uterine natural killer cell function and may be beneficial for a successful pregnancy.
Title: Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion.
JNK1, JNK2 and c-Jun inhibit fibroblast proliferation by negatively regulating the levels of stathmin.
Title: c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.
Aberrant stathmin levels may play a detrimental role in spinal muscular atrophy.
Title: Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy.
results suggest that up-regulation of stathmin1 in the dentate gyrus, secondary to PACAP deficiency, may create abnormal neuronal circuits that cause abnormal behavior
Title: Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations.
STMN1 expression is enhanced by TCDD, and may be involved in accelerated eye opening, probably by stimulating proliferation of corneal epithelial cells.
Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin up-regulates stathmin 1 in the eye: suggestive evidence for the involvement of stathmin 1 in accelerated eye opening in mice induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The Ggamma-globin-Tag model and other SV40/T-antigen driven transgenic mouse models may be useful for testing potential therapies directed at stathmin-1 in human prostate tumors.
Title: Molecular characterization of the Ggamma-globin-Tag transgenic mouse model of hormone refractory prostate cancer: comparison to human prostate cancer.
Data support a model in which stathmin functions in interphase to control the partitioning of tubulins between dimer and polymer pools by setting the number of microtubules per cell.
Title: Stathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning.
Data suggest that regulation of NDRG1 and stathmin by phosphorylation at specific Ser/Thr residues may participate in the cellular response induced by proteasome inhibitors.
Title: Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition.
Loss of STMN1 is correlated with expression changes to genes encoding proteins functioning in cell motility pathways.
Title: Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility.

Submit: New GeneRIF Correction See all (23)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_062615.1	NP_034005.2	Cdkn1b		BIND	PubMed	p27 interacts with stathmin.

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cell differentiation	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
microtubule depolymerization	ISO Inferred from Sequence Orthology more info
mitotic spindle organization	ISO Inferred from Sequence Orthology more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
nervous system development	IEA Inferred from Electronic Annotation more info
positive regulation of cellular component movement	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
intracellular	ISO Inferred from Sequence Orthology more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
microtubule	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: stathmin

Names: stathmin; prosolin; metablastin; oncoprotein 18; phosphoprotein p19; leukemia-associated gene protein; leukemia associated phosphoprotein p18; leukemia-associated phosphoprotein p18

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019641.4 → NP_062615.1 stathmin

Status: VALIDATED

Source sequence(s)

AL669982, BC031831

Consensus CDS

CCDS18772.1

UniProtKB/Swiss-Prot

P54227

UniProtKB/TrEMBL

Q545B6

Related

ENSMUSP00000030636, OTTMUSP00000011615, ENSMUST00000030636, OTTMUST00000025326

Conserved Domains (1) summary

pfam00836
Location:4 – 143
Blast Score: 351

Stathmin; Stathmin family

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38 C57BL/6J

Range

134468320..134473843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

132647807..132653538

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL669982.10 (127623..133141)	None
genomic	CH466552.2	EDL30008.1	mixed
		EDL30009.1	mixed
genomic	L20255.1	None
genomic	L20256.1	None
genomic	L20257.1	None
genomic	L20258.1	None
mRNA	AB064953.1	BAB61894.1	C57BL/6
mRNA	AK002606.1	BAB22225.1	C57BL/6J
mRNA	AK012231.1	BAB28109.1	C57BL/6J
mRNA	AK012347.1	BAB28178.1	C57BL/6J
mRNA	AK013302.1	BAB28778.1	C57BL/6J
mRNA	AK014108.1	BAB29161.1	C57BL/6J
mRNA	AK088628.1	BAC40463.1	NOD
mRNA	BC010581.1	AAH10581.1
mRNA	BC031831.1	AAH31831.1
mRNA	BC054396.1	AAH54396.1
mRNA	X94915.1	CAA64401.1	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P54227.2	GenPept	UniProtKB/Swiss-Prot:P54227
Q545B6	GenPept	UniProtKB/TrEMBL:Q545B6
Q8C2H3	GenPept	UniProtKB/TrEMBL:Q8C2H3
Q91XT3	GenPept	UniProtKB/TrEMBL:Q91XT3
Q9CXQ8	GenPept	UniProtKB/TrEMBL:Q9CXQ8
Q9CYU5	GenPept	UniProtKB/TrEMBL:Q9CYU5
Q9DCP3	GenPept	UniProtKB/TrEMBL:Q9DCP3