Ksr1 kinase suppressor of ras 1 [Mus musculus] - Gene

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Summary

Official Symbol: Ksr1provided by MGI
Official Full Name: kinase suppressor of ras 1provided by MGI
Primary source: MGI:105051
Locus tag: RP23-12I13.1
See related: Ensembl:ENSMUSG00000018334; Vega:OTTMUSG00000000155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hb; Ksr; RSU2; B-KSR1; AW492498; D11Bhm183e; D11Bhm184e

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Genomic context

Location :: 11 B5; 11 45.78 cM

Sequence :: Chromosome: 11; NC_000077.6 (79014801..79146354, complement)

See Ksr1 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a model whereby MARK2 negatively regulates insulin sensitivity in peripheral tissue through inhibition of KSR1
Title: Regulation of glucose homeostasis by KSR1 and MARK2.
Genetic disruption of KSR1 results in striking reductions in kit-ligand-mediated proliferation & degranulation and impacts the biochemical activation of p21-activated kinase.
Title: Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions.
Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.
Title: Compartmentalization of the MAPK scaffold protein KSR1 modulates synaptic plasticity in hippocampal neurons.
findings suggest that Ksr1 functions as a previously unknown scaffold that enhances iNOS activity and is therefore crucial for the pulmonary response to P. aeruginosa infections
Title: Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.
KSR1 is a functional protein kinase, MEK1 is an in vitro substrate of KSR1, and the catalytic activities of both proteins are required for eliciting cell survival responses downstream of TNF.
Title: KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.
Mice lacking both KSR1 and IL-10 develop exacerbated colitis due to dysregulated IFN-gamma production in T lymphocytes.
Title: KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.
despite a requirement for KSR1 for full ERK activation in thymocytes, full and efficient ERK activation is not essential for the majority of thymocyte selection events.
Title: Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.
These findings provide unique insight into the signaling dynamics of the KSR1 scaffold.
Title: Signaling dynamics of the KSR1 scaffold complex.
a specific role for the molecular scaffold KSR1 and KSR1-mediated ERK signaling in the cellular response to DNA interstrand cross-links.
Title: KSR1 is required for cell cycle reinitiation following DNA damage.
KSR1 is recruited to the immunological synapse during T-cell activation; membrane recruitment of KSR1 is required for recruitment of active ERK to the synapse.
Title: The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.

Submit: New GeneRIF Correction See all (24)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_038599.1	NP_082503.1	Brap	BIND	PubMed	IMP interacts with KSR. This interaction was modelled on a demonstrated interaction between IMP from human and KSR from mouse.
NP_038599.1	NP_032953.1	Map2k1	BIND	PubMed	mKsr-1 interacts with MEK-1.
NP_038599.1	NP_035870.1	Ywhaz	BIND	PubMed	Ksr interacts with 14-3-3-zeta.
BioGRID:201048	BioGRID:106799	ANXA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201048	BioGRID:116312	CDC37	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201048	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:201048	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:201048	BioGRID:111590	MAP2K1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Two-hybrid
BioGRID:201048	BioGRID:111591	MAP2K2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:201048	BioGRID:111580	MAPK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:201048	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:201048	BioGRID:204619	Ywhae	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
phosphorylation	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: kinase suppressor of Ras 1

Names: kinase suppressor of Ras 1; mKSR1; protein Hb

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013571.2 → NP_038599.1 kinase suppressor of Ras 1

Status: PROVISIONAL

Source sequence(s)

U43585

Consensus CDS

CCDS25117.1

UniProtKB/Swiss-Prot

Q61097

Related

ENSMUSP00000018478, OTTMUSP00000000212, ENSMUST00000018478, OTTMUST00000000478

Conserved Domains (4) summary

cd00029
Location:334 – 376
Blast Score: 111

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00180
Location:585 – 827
Blast Score: 332

PKc; Catalytic domain of Protein Kinases

pfam07714
Location:563 – 827
Blast Score: 404

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:39 – 166
Blast Score: 482

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38 C57BL/6J

Range

79014801..79146354, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

88647821..88779700, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL592551.10	CAI24046.1
		CAI24047.1
		CAI24048.1
		CAI24049.1
genomic	CH466556.1	EDL15601.1	mixed
		EDL15602.1	mixed
mRNA	AK036566.1	None	C57BL/6J
mRNA	AK137532.1	BAE23398.1	C57BL/6J
mRNA	AK164833.1	None	C57BL/6J
mRNA	U43585.1	AAC52382.1
mRNA	X81634.1	CAA57288.1	BALB/c
other-genetic	BC168386.1	AAI68386.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3UV75	GenPept	UniProtKB/TrEMBL:Q3UV75
Q5SXE1	GenPept	UniProtKB/TrEMBL:Q5SXE1
Q5SXE2	GenPept	UniProtKB/TrEMBL:Q5SXE2
Q5SXE4	GenPept	UniProtKB/TrEMBL:Q5SXE4
Q61097.1	GenPept	UniProtKB/Swiss-Prot:Q61097