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Ksr1 kinase suppressor of ras 1 [ Mus musculus (house mouse) ]

Gene ID: 16706, updated on 21-Apr-2024

Summary

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Official Symbol
Ksr1provided by MGI
Official Full Name
kinase suppressor of ras 1provided by MGI
Primary source
MGI:MGI:105051
See related
Ensembl:ENSMUSG00000018334 AllianceGenome:MGI:105051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hb; Ksr; RSU2; mKSR1; B-KSR1; D11Bhm183e; D11Bhm184e
Summary
Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and Hsp90 protein binding activity. Involved in intracellular signal transduction; regulation of MAP kinase activity; and regulation of cell population proliferation. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be located in cell projection and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 15.8), small intestine adult (RPKM 14.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.74 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78904266..79037357, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79013440..79146533, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Nos2 promoter region Neighboring gene nitric oxide synthase 2, inducible Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78787018-78787219 Neighboring gene lectin, galactose binding, soluble 9 Neighboring gene STARR-seq mESC enhancer starr_30105 Neighboring gene STARR-seq mESC enhancer starr_30106 Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene predicted gene, 30413 Neighboring gene STARR-positive B cell enhancer ABC_E5253 Neighboring gene STARR-seq mESC enhancer starr_30112 Neighboring gene predicted gene, 30470 Neighboring gene WD repeat and SOCS box-containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calmodulin influences MAPK signaling by binding KSR1. Parvathaneni S, et al. J Biol Chem, 2021 Jan-Jun. PMID 33766558, Free PMC Article
  2. Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. Sibilski C, et al. J Biol Chem, 2013 Dec 6. PMID 24158441, Free PMC Article
  3. Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells. Le Borgne M, et al. PLoS One, 2013. PMID 23431403, Free PMC Article
  4. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Li X, et al. Cell Physiol Biochem, 2012. PMID 23221422, Free PMC Article
  5. Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis. Gramling MW, et al. Cell Death Differ, 2012 Jul. PMID 22301919, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calmodulin influences MAPK signaling by binding KSR1.
    Title: Calmodulin influences MAPK signaling by binding KSR1.
  2. DiRas3 binds to KSR1 independently of its interaction with activated Ras and RAF.
    Title: Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.
  3. praja2 regulates KSR1 stability and mitogenic signaling.
    Title: praja2 regulates KSR1 stability and mitogenic signaling.
  4. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding.
    Title: Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.
  5. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.
    Title: Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation.
  6. propose that phosphorylation of Tyr(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses
    Title: Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.
  7. Data indicate that phosphorylation of BRAF by AMPK disrupts its association with KSR1.
    Title: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.
  8. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR-dependent T cell differentiation.
    Title: Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.
  9. Ksr1 plays a dispensable role in lipopolysaccharide (LPS)-induced ERK activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS model.
    Title: Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury.
  10. the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.
    Title: A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP-kinase scaffold activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
kinase suppressor of Ras 1
Names
protein Hb
NP_001335136.1
NP_038599.1
XP_006532397.1
XP_006532398.1
XP_011247072.1
XP_011247073.1
XP_011247074.1
XP_011247075.1
XP_011247076.1
XP_011247077.1
XP_036012252.1
XP_036012253.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348207.1 → NP_001335136.1  kinase suppressor of Ras 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK137532, CX204281, U43585
    Consensus CDS
    CCDS88203.1
    UniProtKB/TrEMBL
    A0A2I3BR95, Q3UV75
    Related
    ENSMUSP00000154385.2, ENSMUST00000226282.2
    Conserved Domains (3) summary
    cd00029
    Location:252 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:480 → 758
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:42 → 84
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  2. NM_013571.3 → NP_038599.1  kinase suppressor of Ras 1 isoform 1

    See identical proteins and their annotated locations for NP_038599.1

    Status: VALIDATED

    Source sequence(s)
    AK137532, AK164833, CX204281, U43585
    Consensus CDS
    CCDS25117.1
    UniProtKB/Swiss-Prot
    Q61097, Q61648, Q78DX8
    UniProtKB/TrEMBL
    Q3UV75
    Related
    ENSMUSP00000018478.5, ENSMUST00000018478.11
    Conserved Domains (4) summary
    cd00029
    Location:334 → 376
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:562 → 840
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam07714
    Location:563 → 827
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78904266..79037357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248771.4 → XP_011247073.1  kinase suppressor of Ras 1 isoform X2

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:334 → 376
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:562 → 840
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  2. XM_011248770.4 → XP_011247072.1  kinase suppressor of Ras 1 isoform X1

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:334 → 376
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:576 → 854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  3. XM_036156359.1 → XP_036012252.1  kinase suppressor of Ras 1 isoform X3

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd14152
    Location:576 → 854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cd20872
    Location:332 → 378
    C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

  4. XM_036156360.1 → XP_036012253.1  kinase suppressor of Ras 1 isoform X7

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd14152
    Location:562 → 840
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
    cd20872
    Location:332 → 378
    C1_KSR1; protein kinase C conserved region 1 (C1 domain) found in kinase suppressor of Ras 1 (KSR1) and similar proteins

  5. XM_006532334.5 → XP_006532397.1  kinase suppressor of Ras 1 isoform X5

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:334 → 376
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:576 → 854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  6. XM_006532335.5 → XP_006532398.1  kinase suppressor of Ras 1 isoform X6

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:334 → 376
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:576 → 854
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:39 → 166
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  7. XM_011248775.3 → XP_011247077.1  kinase suppressor of Ras 1 isoform X4

    See identical proteins and their annotated locations for XP_011247077.1

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (2) summary
    cd00029
    Location:199 → 241
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:441 → 719
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

  8. XM_011248772.3 → XP_011247074.1  kinase suppressor of Ras 1 isoform X4

    See identical proteins and their annotated locations for XP_011247074.1

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (2) summary
    cd00029
    Location:199 → 241
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:441 → 719
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1

  9. XM_011248774.4 → XP_011247076.1  kinase suppressor of Ras 1 isoform X9

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:220 → 262
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:462 → 740
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:1 → 52
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

  10. XM_011248773.4 → XP_011247075.1  kinase suppressor of Ras 1 isoform X8

    UniProtKB/TrEMBL
    Q3UV75
    Conserved Domains (3) summary
    cd00029
    Location:252 → 294
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14152
    Location:494 → 772
    STKc_KSR1; Catalytic domain of the Serine/Threonine Kinase, Kinase Suppressor of Ras 1
    pfam13543
    Location:42 → 84
    KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

RNA

  1. XR_004936797.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61097.1 GenPept UniProtKB/Swiss-Prot:Q61097

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