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    SPATA5 spermatogenesis associated 5 [ Homo sapiens (human) ]

    Gene ID: 166378, updated on 9-Jun-2013
    Official Symbol
    SPATA5provided by HGNC
    Official Full Name
    spermatogenesis associated 5provided by HGNC
    Primary source
    HGNC:18119
    See related
    HPRD:11595; MIM:613940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AFG2; SPAF
    Location :
    4q28.1
    Sequence :
    Chromosome: 4; NC_000004.11 (123844225..124240605)
    See SPATA5 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 23 Neighboring gene fibroblast growth factor 2 (basic) Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 6 Neighboring gene coilin pseudogene 2 Neighboring gene sprouty homolog 1, antagonist of FGF signaling (Drosophila) Neighboring gene transfer RNA cysteine 16 (anticodon GCA)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.
    2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.
    3. Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata. Forstbauer LM, et al. Eur J Hum Genet, 2012 Mar. PMID 22027810.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SPATA5 locus is a new susceptibility locus for Alopecia areata (AA).
      Title: Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:127927 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    spermatogenesis-associated protein 5
    Names
    spermatogenesis-associated protein 5
    ATPase family gene 2 homolog
    ATPase family protein 2 homolog
    spermatogenesis associated factor SPAF
    spermatogenesis-associated factor protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145207.2 → NP_660208.2  spermatogenesis-associated protein 5

      Status: VALIDATED

      Source sequence(s)
      AC026402, AK091384, AL832175, CR738547, DA619323
      Consensus CDS
      CCDS3730.1
      UniProtKB/Swiss-Prot
      Q8NB90
      Conserved Domains (3) summary
      COG0464
      Location:370 – 873
      Blast Score: 1171
      SpoVK; ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]
      cd00009
      Location:630 – 796
      Blast Score: 263
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart01073
      Location:65 – 133
      Blast Score: 92
      CDC48_N; Cell division protein 48 (CDC48) N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      123844225..124240605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      119570673..119967245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      123629949..124026337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01044743.1 (95542..160730) None
    genomic ABBA01044744.1 None
    genomic ABBA01044745.1 None
    genomic ABBA01044746.1 None
    genomic ABBA01044747.1 None
    genomic ABBA01044748.1 None
    genomic AC021205.6 (112989..176917) None
    genomic AC026402.3 (77843..82668) None
    genomic AC097492.6 None
    genomic AC109357.3 None
    genomic AMYH01014495.1 (23003..115777) None
    genomic AMYH01014496.1 None
    genomic AMYH01014497.1 None
    genomic CH471056.2 EAX05213.1
      EAX05214.1
      EAX05215.1
      EAX05216.1
    mRNA AF361489.1 AAM00262.1
    mRNA AF479656.1 AAM43608.1
    mRNA AK091384.1 BAC03651.1
    mRNA AL832175.1 None
    mRNA BC048217.1 AAH48217.1
    mRNA CR738547.1 None
    mRNA DA619323.1 None
    other-genetic AM392939.1 CAL37817.1
    other-genetic AM393832.1 CAL38707.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NB90.3 GenPept UniProtKB/Swiss-Prot:Q8NB90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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