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Klf4 Kruppel-like factor 4 (gut) [ Mus musculus (house mouse) ]

Gene ID: 16600, updated on 23-Aug-2015
Official Symbol
Klf4provided by MGI
Official Full Name
Kruppel-like factor 4 (gut)provided by MGI
Primary source
MGI:MGI:1342287
See related
Ensembl:ENSMUSG00000003032; Vega:OTTMUSG00000007231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EZF; Zie; Gklf
Orthologs
See Klf4 in Epigenomics, MapViewer
Location:
4 B3; 4 29.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (55527137..55532475, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (55540009..55545347, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34290 Neighboring gene predicted gene 12505 Neighboring gene predicted gene 12506 Neighboring gene predicted gene, 34343 Neighboring gene predicted gene 12511

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription cofactor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding transcription factor recruiting IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-8 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle hyperplasia ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
post-embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
stem cell maintenance IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
Krueppel-like factor 4
Names
Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)
epithelial zinc finger protein EZF
gut-enriched krueppel-like factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010637.3NP_034767.2  Krueppel-like factor 4

    See identical proteins and their annotated locations for NP_034767.2

    Status: VALIDATED

    Source sequence(s)
    AA389216, AK141244, AL732494, BQ034021, CF163360
    Consensus CDS
    CCDS18195.2
    UniProtKB/TrEMBL
    F2YID5
    UniProtKB/Swiss-Prot
    Q60793
    Related
    ENSMUSP00000103245, OTTMUSP00000007677, ENSMUST00000107619, OTTMUST00000016677
    Conserved Domains (3) summary
    COG5048
    Location:395478
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:446471
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:402424
    ZF_C2H2; Zn binding site [ion binding]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    55527137..55532475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    55439526..55444543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)