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    Klf3 Kruppel-like factor 3 (basic) [ Mus musculus (house mouse) ]

    Gene ID: 16599, updated on 9-Jun-2013
    Official Symbol
    Klf3provided by MGI
    Official Full Name
    Kruppel-like factor 3 (basic)provided by MGI
    Primary source
    MGI:1342773
    See related
    Ensembl:ENSMUSG00000029178
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bklf; Tef-2; AL024007; 9930027G08Rik
    Location :
    5 C3.1; 5
    Sequence :
    Chromosome: 5; NC_000071.6 (64803523..64830129)
    See Klf3 in Epigenomics, MapViewer

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C030018K13 gene Neighboring gene predicted gene 3716 Neighboring gene predicted gene, 20033 Neighboring gene toll-like receptor 1 pseudogene Neighboring gene toll-like receptor 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Funnell AP, et al. Mol Cell Biol, 2012 Aug. PMID 22711990.
    2. Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development. Bonilla-Claudio M, et al. Development, 2012 Feb. PMID 22219353.
    3. Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements. Kitamura T, et al. Gene, 2012 Jan 25. PMID 22115574.
    4. Impaired B cell development in the absence of Krüppel-like factor 3. Vu TT, et al. J Immunol, 2011 Nov 15. PMID 22003205.
    5. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673.

    See all (41) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. KLF3 is a feedback repressor that counters the activity of EKLF at selected target genes to achieve normal erythropoiesis
      Title: The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
    2. we concluded that KLF3 is a transcriptional repressor for wee1 gene.
      Title: Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements.
    3. KLF3 is a driving force toward marginal zone B-cell maturation.
      Title: Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3).
    4. KLF3 is an important regulator of several biological processes, including adipogenesis, erythropoiesis, and B cell development. (Review)
      Title: The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF).
    5. role for KLF3 in muscle gene regulation and an alternate mechanism for transcriptional regulation by SRF via its recruitment to KLF binding sites
      Title: KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding sites.
    6. Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
      Title: A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
    7. basic Kruppel-like factor gene (Klf3) has a role with CtBP in adipogenesis
      Title: Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
    8. in erythroid tissues basic Kruppel-like factor (Bklf/Klf3) expression is highly dependent on another family member, erythroid Kruppel-like factor (Eklf/Klf1)
      Title: Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.
    9. Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81.
      Title: Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (knock-out) (1)  1 citation
    • Targeted (knock-in) (1) 
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:200965 BioGRID:198962 Ctbp2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC151315

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    Krueppel-like factor 3
    Names
    Krueppel-like factor 3
    basic krueppel-like factor
    CACCC-box-binding protein BKLF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008453.5 → NP_032479.1  Krueppel-like factor 3

      Status: PROVISIONAL

      Source sequence(s)
      AC130535
      Consensus CDS
      CCDS19301.1
      UniProtKB/TrEMBL
      Q545J5
      UniProtKB/Swiss-Prot
      Q60980
      Related
      ENSMUSP00000129363, ENSMUST00000165536
      Conserved Domains (2) summary
      COG5048
      Location:169 – 331
      Blast Score: 90
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:305 – 330
      Blast Score: 103
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p1 C57BL/6J

      Range
      64803523..64830129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      62088896..62102287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01045247.1 (5228..18619) None
    genomic AC130535.4 (65330..91937) None
    genomic CH466524.1 EDL37719.1 mixed
      EDL37720.1 mixed
      EDL37721.1 mixed
    mRNA AJ810305.1 CAH17795.1 BALB/c
    mRNA AJ810306.1 CAH17796.1 BALB/c
    mRNA AK007959.1 BAB25371.1 C57BL/6J
    mRNA AK010713.1 None C57BL/6J
    mRNA AK029070.1 None C57BL/6J
    mRNA AK036932.1 None C57BL/6J
    mRNA AK046659.1 None C57BL/6J
    mRNA AK081467.1 BAC38227.1 C57BL/6J
    mRNA AK136516.1 None C57BL/6J
    mRNA AK143838.1 BAE25562.1 C57BL/6J
    mRNA AK157576.1 None NOD
    mRNA AK185328.1 None
    mRNA BC116938.1 AAI16939.1
    mRNA BC119214.1 AAI19215.1
    mRNA DQ981866.1 ABI93805.1 129
    mRNA U36340.1 AAA93256.1 DBA
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60980.1 GenPept UniProtKB/Swiss-Prot:Q60980

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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