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Kifap3 kinesin-associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 16579, updated on 8-May-2016
Official Symbol
Kifap3provided by MGI
Official Full Name
kinesin-associated protein 3provided by MGI
Primary source
MGI:MGI:107566
See related
Ensembl:ENSMUSG00000026585 Vega:OTTMUSG00000018234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP3; SMAP; KAP-3
Summary
The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Orthologs
Location:
1; 1 H1
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (163762139..163917104)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (165709810..165847231)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene methyltransferase like 11B Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene cDNA sequence BC055324 Neighboring gene methyltransferase like 18

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
microtubule-based process IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium-dependent cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
axoneme IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with intraciliary transport particle IDA
Inferred from Direct Assay
more info
PubMed 
kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
kinesin II complex IPI
Inferred from Physical Interaction
more info
PubMed 
kinesin II complex ISO
Inferred from Sequence Orthology
more info
 
kinesin complex IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
neuron part IC
Inferred by Curator
more info
PubMed 
periciliary membrane compartment IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor inner segment IC
Inferred by Curator
more info
PubMed 
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
kinesin-associated protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305643.1NP_001292572.1  kinesin-associated protein 3 isoform KAP3A

    See identical proteins and their annotated locations for NP_001292572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (KAP3A, PMID:8710890).
    Source sequence(s)
    AK013954, AK133957, BC040362, BU701040
    Consensus CDS
    CCDS78729.1
    UniProtKB/Swiss-Prot
    P70188
    UniProtKB/TrEMBL
    Q3UZA5, Q9CRX5
    Conserved Domains (2) summary
    cd00020
    Location:578662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:13720
    KAP; Kinesin-associated protein (KAP)
  2. NM_010629.3NP_034759.1  kinesin-associated protein 3 isoform KAP3B

    See identical proteins and their annotated locations for NP_034759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (KAP3B, PMID:8710890) is shorter and has a distinct C-terminus, compared to KAP3A.
    Source sequence(s)
    AK013954, BC040362, BU701040
    Consensus CDS
    CCDS35751.1
    UniProtKB/Swiss-Prot
    P70188
    UniProtKB/TrEMBL
    Q9CRX5
    Related
    ENSMUSP00000076830, OTTMUSP00000019806, ENSMUST00000077642, OTTMUST00000044067
    Conserved Domains (2) summary
    cd00020
    Location:578662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:13720
    KAP; Kinesin-associated protein (KAP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    163762139..163917104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496681.2XP_006496744.1  

    Conserved Domains (2) summary
    cd00020
    Location:594678
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:29736
    KAP; Kinesin-associated protein (KAP)
  2. XM_006496679.2XP_006496742.1  

    Conserved Domains (2) summary
    cd00020
    Location:594678
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:29736
    KAP; Kinesin-associated protein (KAP)
  3. XM_006496680.1XP_006496743.1  

    Related
    ENSMUSP00000027877, OTTMUSP00000019807, ENSMUST00000027877, OTTMUST00000044068
    Conserved Domains (2) summary
    cd00020
    Location:578662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam05804
    Location:13720
    KAP; Kinesin-associated protein (KAP)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    166219175..166357571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)